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J-GLOBAL ID：200901018173821829   Update date: Mar. 24, 2024

Kunisawa Jun

クニサワ ジュン | Kunisawa Jun
Affiliation and department：
National Institutes of Biomedical Innovation,Health and Nutrition Center for Vaccine and Adjuvant Research

About National Institutes of Biomedical Innovation,Health and Nutrition Center for Vaccine and Adjuvant Research


Job title： Director
Other affiliations (7)：
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Homepage URL  (2)： http://www.nibiohn.go.jp/vaccine_material_project/index.html ,  http://www.nibiohn.go.jp/vaccine_material_project/english/index.html
Research field  (2)： Immunology ,  Pharmaceuticals - chemistry and drug development
Research keywords  (10)： 抗原提示 ,  食餌性成分 ,  腸内細菌 ,  粘膜ワクチン ,  免疫疾患 ,  粘膜免疫 ,  Vaccine ,  Food ,  Microbiota ,  Mucosal Immunol
Research theme for competitive and other funds  (13)：
  • 2022 - 2027 Understanding a mechanism of an onset of colorectal cancer by colibactin and finding compounds inhibiting colibactin biosynthetic enzymes
  • 2020 - 2025 Understanding the mechanism of the cutaneous immune-diversity and its relationship with other organs
  • 2021 - 2024 Analysis of the relationship between protein energy malnutrition and gut microbiota, and verification of the improvement effect by diet
  • 2021 - 2024 高齢者への食習慣介入による腸内環境改善および認知機能低下抑制効果の検討
  • 2021 - 2024 アレルギー・炎症性疾患における免疫メタボリズムと外的因子の影響
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Papers (234)：
  • Shino Yamasaki-Yashiki, Fumie Kawashima, Azusa Saika, Ryota Hosomi, Jun Kunisawa, Yoshio Katakura. RNA-Based Anti-Inflammatory Effects of Membrane Vesicles Derived from Lactiplantibacillus plantarum. Foods. 2024. 13. 6. 967-967
  • Chiharu Iwasaka, Hinako Nanri, Takashi Nakagata, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Haruka Murakami, Koji Hosomi, Jonguk Park, Yosuke Yamada, et al. Association of skeletal muscle function, quantity, and quality with gut microbiota in Japanese adults: A cross-sectional study. Geriatrics & gerontology international. 2023
  • Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Azusa Saika, Haruki Yamaura, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue. International Immunology. 2023
  • Eiichi Yoshimura, Yuka Hamada, Yoichi Hatamoto, Takashi Nakagata, Hinako Nanri, Yui Nakayama, Takanori Hayashi, Ippei Suzuki, Takafumi Ando, Kazuko Ishikawa-Takata, et al. Effects of energy loads on energy and nutrient absorption rates and gut microbiome in humans: A randomized crossover trial. Obesity. 2023
  • Nanaho Kasahara, Yukiko Imi, Reina Amano, Masakazu Shinohara, Kumiko Okada, Yusei Hosokawa, Makoto Imamori, Chiaki Tomimoto, Jun Kunisawa, Shigenobu Kishino, et al. A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells. Scientific Reports. 2023. 13. 1
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MISC (139)：
  • 吉井 健, 細見 晃司, 國澤 純. 感染症対策に効果的に機能する腸内環境の構築と腸内細菌のかかわり (特集 感染症予防に効果的な生活習慣). 体育の科学. 2021. 71. 5. 341-345
  • 秋田真悠子, 齋藤雄太朗, 雑賀あずさ, 雑賀あずさ, 長竹貴広, 國澤純, 國澤純, 山東信介. Synthesis of 17,18-EpETE analogues to elucidate the molecular mechanism of anti-inflammatory effect. 日本化学会春季年会講演予稿集(Web). 2021. 101st
  • 庄真喜子, 橘敬祐, 原田和生, 平田收正, 堤康央, 國澤純, 國澤純, 國澤純, 國澤純, 國澤純, et al. Current situation and challenges of a regulatory concept of pharmacokinetics focusing on microbiome. 腸内細菌学雑誌. 2021. 35. 2
  • 細見 晃司, 國澤 純. 腸内免疫学から考える新しいワクチン学. 小児科 = Pediatrics of Japan. 2020. 61. 11. 1545-1552
  • Immunological Health Regulated by Diets and Intestinal Bacteria. 2020. 34. 4. 217-220
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Books (22)：
  • Lymphoid tissues associated with gastrointestinal (GI) mucosa
    Springer 2019
  • Influence of dietary components and commensal bacteria on the control of mucosal immunity
    Elsevier 2019
  • Lymph Node Metastasis in Gastrointestinal Cancer
    Sprineger 2019
  • Mucosal Vaccines: Innovation for Preventing Infectious Diseases 2nd edition
    Elsevier (in press) 2019
  • 腸内細菌叢を標的にした医薬品と保健機能食品の開発
    技術情報協会 2018 ISBN:4861047242
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Lectures and oral presentations  (268)：
  • 「腸内細菌・食事・免疫」から考える腸内環境の理解と健康未来
    (第24回 静岡小児臨床研究ネットワーク勉強会 2019)
  • 腸内環境から眺める健康科学の近未来と創薬研究への新展開
    (東京理科大セミナー 2019)
  • 腸内環境から考える健康科学の将来展望
    (腸内フローラ移植臨床研究会 第3回総会 2019)
  • 腸内環境を起点とした創薬研究の課題と展望
    (第92回 日本生化学会 2019)
  • 腸内細菌叢研究とデータの取得・解析
    (技術情報協会セミナー 2019)
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Education (4)：
  • 1996 - 2001 大阪大学大学院 薬学研究科 応用医療薬科学
  • - 2001 Osaka University Graduate School, Division of Pharmaceutical Sciences
  • 1992 - 1996 Osaka University School of Pharmaceutical Sciences
  • - 1996 Osaka University Faculty of Pharmaceutical Science
Professional career (1)：
  • Ph.D(Pharmaceutical Sciences) (Osaka University)
Work history (10)：
  • 2019/01 - 現在 National Institutes of Biomedical Innovation, Health and Nutrition Center for Vaccine and Adjuvant Research Director
  • 2015/04 - 現在 National Institutes of Biomedical Innovation, Health and Nutrition
  • 2013/01 - 2015/03 National Institutes of Biomedical Innovation, Health and Nutrition
  • 2012/08 - 2013/12 The University of Tokyo The Institute of Medical Science
  • 2007/10 - 2012/07 東京大学新領域創成科学研究科 講師(兼任)
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Awards (13)：
  • 2020/12 - 多ヶ谷勇記念ワクチン研究イスクラ奨励賞
  • 2018 - 日本ワクチン学会 高橋奨励賞
  • 2018 - バイオインダストリー奨励賞
  • 2016 - 日本食品免疫学会賞
  • 2016 - 三島海雲学術賞
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Association Membership(s) (1)：
日本公衆衛生学会
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