Ikeda Takayuki

イケダタカユキ | Ikeda Takayuki

Affiliation and department：

Research field (1)： Medical biochemistry

Research keywords (3)： Biochemistry , 選択的mRNAプロセシング , 血管新生の制御機構

Research theme for competitive and other funds (8)：

2022 - 2026 コラーゲン・トリペプチドの血管保護作用の機序解明と疾病に対する予防治療効果の検証
2022 - 2025 メカノセンサーPiezo1-JunBシグナルが制御する血管リモデリング機構の解明
2019 - 2023 紫外線暴露により水晶体で発現誘導されるOtx2の白内障発症における役割の解明
2021 - 2023 敗血症における血管内皮細胞で産生されるsFlt-1の役割の解明
2021 - 2021 E3ユビキチンリガーゼHUWE1のRheb活性化における役割の解明

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Papers (73)：

Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Ryo Yamamoto, Takafumi Furuyama, Yasuhito Ishigaki, Nobuo Kato, Hideto Yonekura, Takayuki Ikeda. Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models. International journal of molecular sciences. 2023. 24. 4
Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki, Hideto Yonekura. EPAC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells. Scientific reports. 2021. 11. 1. 19453-19453
Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katsuda, Hideto Yonekura, et al. Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression. Nutrients. 2021. 13. 7
Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito-Takatsuji, Hideto Yonekura. Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development. International journal of molecular sciences. 2021. 22. 6
ao Yao, Hong Sungki, Ikeda Takayuki, Nada, Shigeyuki, Okada, Masato, Inoki, Ken, Yao, Yao, Hong, Sungki, Ikeda, Takayuki, Mori, Hiroyuki, et al. Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity ll Article Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquiti. Molecular Cell. 2020. 80. 3. 437-451

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MISC (21)：

Y. Yoshitake, T. Ikeda, Y. Yoshitomi, H. Yonekura. Increased expression of Epac2 during in vitro tube formation of human microvascular endothelial cells. FEBS JOURNAL. 2012. 279. 174-174
T. Ikeda, Y. Yoshitomi, Y. Ishigaki, Y. Yoshitake, H. Yonekura. Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing. FEBS JOURNAL. 2011. 278. 86-86
Y. Yoshitake, H. Osada, T. Ikeda, Y. Yoshitomi, Y. Ishigaki, H. Sasaki, H. Yonekura. Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells. FEBS JOURNAL. 2011. 278. 191-191
N. J. Shervani, N. Noguchi, T. Ikeda, I. Takahashi, T. Yoshikawa, A. Yamauchi, A. Uruno, K. Nata, S. Takasawa, H. Okamoto, et al. Autoantibodies to REG family proteins in Japanese diabetes patients. DIABETOLOGIA. 2009. 52. S114-S114
I. Takahashi, K. Nata, N. Noguchi, T. Ikeda, K. Sugihara, M. Asano, T. Yoshikawa, A. Yamauchi, N. J. Shervani, A. Uruno, et al. Reduced beta cell proliferation and impaired glucose tolerance in pancreatic beta cell specific Extl3 knockout mice. DIABETOLOGIA. 2008. 51. S307-S307

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Lectures and oral presentations (42)：

うつモデルマウスの脳海馬で発現変動する遺伝子の探索と役割の解明
(第39回分子病理研究会 2022)
Mechanisms of automaticity and early afterdepolarization in HL-1 mouse atrial myocytes.
(2022)
HL-1細胞におけるIK1電流の解析と発現制御
(第68回中部日本生理学会 2021)
Characterization and Expression Regulation of Inward-rectifier K+ Channel in HL-1 Mouse Atrial Myocytes.
(2021)
HL-1マウス心筋細胞を用いた自動能機序の解明
(第67回中部日本生理学会 2020)

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Education (2)：

2000 - 2004 Tohoku University Graduate School Division of Medicine
1995 - 1999 Tohoku University Faculty of Science

Professional career (2)：

Ph.D in Medicine
障害科学修士

Work history (5)：

2018/06 - 現在 Kanazawa Medical University School of Medicine
2015/07 - 2018/03 Universityof Michigan Life Sciences Institute Research Investigator
2008/09 - Kanazawa Medical University
2006/04 - 2008/08 科学技術振興機構JSTイノベーションプラザ宮城研究員
2004/04 - 2006/03 Tohoku University

Awards (8)：

2017/07 - Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation.
2017/07 - 金沢医科大学医学会金沢医科大学医学会「論文表彰」 Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation.
2013 - Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate. Mol Cell Biochem, 366(1-2):69-80, 2012.
2013 - 金沢医科大学医学会金沢医科大学医学会「論文表彰」 Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate. Mol Cell Biochem, 366(1-2):69-80, 2012.
2012/05 - 低酸素刺激による微小血管内皮細胞の可溶型VEGF受容体(可溶型Flt-1)産生の抑制

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