Art

J-GLOBAL ID：202002278152987023   Reference number：20A2564118

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

アミノ酸はRhebのポリユビキチン化を増強し,リソソームATXN3デユビキチナーゼ活性を阻害することによりmTORC1に結合する【JST・京大機械翻訳】

Author (12)： Yao Yao (Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA) ,  Hong Sungki (Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA) ,  Ikeda Takayuki (Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA) ,  Ikeda Takayuki (Department of Biochemistry, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan) ,  Mori Hiroyuki (Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1137 E. Catherine St., Ann Arbor, MI 48109-5622, USA) ,  MacDougald Ormond A. (Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1137 E. Catherine St., Ann Arbor, MI 48109-5622, USA) ,  MacDougald Ormond A. (Department of Internal Medicine, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5368, USA) ,  Nada Shigeyuki (Department of Oncogene Research, the Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Okada Masato (Department of Oncogene Research, the Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan) ,  Inoki Ken (Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA) ,  Inoki Ken (Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1137 E. Catherine St., Ann Arbor, MI 48109-5622, USA) ,  Inoki Ken (Department of Internal Medicine, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5368, USA)
Material： Molecular Cell  (Mol Cell)
Volume： 80  Issue： 3  Page： 437-451.e6  Publication year： 2020 
JST Material Number： W1167A  ISSN： 1097-2765  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Amino-acid-induced lysosomal m...

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Thesaurus term： interaction ,  *amino acid ,  complex(substance) ,  *lysosome ,  *ubiquitin ,  growth factor ,  cellular signal transduction ,  crosstalk(interaction) ,  post-translational modification
Semi thesaurus term： ヘテロ二量体 ,  *ポリユビキチン化 ,  *脱ユビキチン化酵素 ,  局在化 ,  *mTORC1 ,  脱ユビキチン化 , 【Automatic Indexing@JST】

Author keywords (9)： Rheb ,  ATXN3 ,  ubiquitin ,  deubiquitination ,  lysosome ,  Rag ,  Ragulator ,  mTORC1 ,  amino acids

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Terms in the title (9)： アミノ酸 ,  Rheb ,  ポリユビキチン化 ,  増強 ,  リソソーム ,  デユビキチナーゼ ,  活性 ,  阻害 ,  mTORC1