2019 - 2022 Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies
2018 - 2021 Understanding of the mechanism of ribitol-phosphate modification and application of its physiological function to therapy
2006 - 2008 Study of abnormal activation of calpain by klotho protein deficiency
2005 - 2007 神経移動障害を伴う筋疾患の病態解明と治療法実現に向けた技術集約的研究
2003 - 2005 Klotho蛋白質によるカルパインの活性制御機構の解析
2001 - 2002 アミロイド前駆体蛋白質糖鎖変化の老人斑形成における意義
2000 - 2001 Elucidation of function of astrocytes appearedin aded brain and its inducing factor
複合糖質の生体内における役割
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Papers (92):
Hisatoshi Hanamatsu, Ikuko Yokota, Masaki Kurogochi, Keiko Akasaka-Manya, Nobuaki Miura, Hiroshi Manya, Tamao Endo, Takashi Nishikaze, Jun-Ichi Furukawa, Koichi Tanaka. Direct derivatization of sialic acids and mild β-elimination for linkage-specific sialyl O-glycan analysis. Analytica chimica acta. 2024. 1318. 342945-342945
Rieko Imae, Hiroshi Manya, Hiroki Tsumoto, Keitaro Umezawa, Yuri Miura, Tamao Endo. Changes in the amount of nucleotide sugars in aged mouse tissues. Glycobiology. 2024. 34. 6
Shunsuke Hoshino, Hiroshi Manya, Rieko Imae, Kazuhiro Kobayashi, Motoi Kanagawa, Tamao Endo. Endogenous reductase activities for the generation of ribitol-phosphate, a CDP-ribitol precursor, in mammals. The Journal of Biochemistry. 2023
Yuriko Tachida, Junko Iijima, Kazuto Takahashi, Hideaki Suzuki, Yasuhiko Kizuka, Yoshiki Yamaguchi, Katsunori Tanaka, Miyako Nakano, Daisuke Takakura, Nana Kawasaki, et al. O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production. The Journal of biological chemistry. 2023. 299. 7. 104905-104905
2013/04 - 2023/03 Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology Molecular Glycobiology, Research team for Mechanism of Aging Leader
2024 - 現在 The Japanese Biochemical Society Councilor
2019 - 現在 日本基礎老化学会 評議員
2015 - 現在 日本糖質学会 評議員
2017 - 2023 日本薬学会 ファルマシア委員
2011 - 2016 日本基礎老化学会 会計幹事
Awards (7):
2022 - The Japanese Biochemical Society JB Award PCYT2 synthesizes CDP-glycerol in mammals and reduced PCYT2 enhances the expression of functionally glycosylated α-dystroglycan
2019 - The Japan Geriatrics Society Poster Award
2019 - The Pharmaceutical Society of Japan The PSJ Award for Divisional Scientific Promotion Elucidation of pathology and drug development for muscular dystrophy through the comprehension of novel glycosylation mechanisms
2018 - JB Award Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production
2011 - JB Award Role of N-glycans in maintaining the activity of protein O-mannosyltransferases POMT1 and POMT2