Shiomi Masashi

シオミマサシ | Shiomi Masashi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://www.med.kobe-u.ac.jp/iea/index.html

Research field (3)： Experimental pathology , Pathobiochemistry , Laboratory animal science

Research keywords (4)： lipoprotein metabolism , hypercholesterolemia , atherosclerosis , animal model for human diseases

Research theme for competitive and other funds (8)：

2014 - 2017 世界初の急性冠症候群疾患モデルの実現
2011 - 心筋梗塞発症および冠動脈病変不安定化に関わるバイオマーカーの同定
2010 - 厚生科研「糖尿病関連血管病(動脈硬化・足病変)の早期診断・治療のための高感度分子イメージングプローブの開発」
2010 - 厚生科研「急性冠症候群の疾患モデルウサギの開発及びバイオリソ-スの樹立」
2009 - 厚生科研「糖尿病関連血管病の早期診断・治療のための高感度分子イメージングプロープの開発」

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Papers (69)：

Ning B, Chen Y, Waquar AB, Yan H, SHIOMI MASASHI, Zhang J, Chen YE, Wang Y, Itabe H, Liang J, et al. Hypertension enhances advanced atherosclerosis and induces cardiac death in Watanabe heritable hyperlipidemic rabbits. Am J Pathol. 2018
Hiroaki Takeda, Yoshihiro Izumi, Masatomo Takahashi, Thanai Paxton, Shohei Tamura, Tomonari Koike, Ying Yu, Noriko Kato, Katsutoshi Nagase, Masashi Shiomi, et al. Widely-targeted quantitative lipidomics method by supercritical fluid chromatography triple quadrupole mass spectrometry. Journal of lipid research. 2018. 59. 7. 1283-1293
Temma T, Kondo N, Yoda K, Nishigori K, Onoe S, SHIOMI MASASHI, Ono M, Saji H. Comparison of ¹²⁵I- and ¹¹¹In-labeled peptide probes for in vivo detection of oxidized low-density lipoprotein in atherosclerotic plaques. Ann Nucl Med. 2018. 32. 6. 425-429
Ryosuke Nagasaka, Tomonari Koike, Norie Tsukada, Shohei Tamura, Masashi Shiomi. The Coronary Artery Running Pattern is One of the Causes of Individual Differences in the Progression of Coronary Atherosclerosis in WHHLMI Rabbits, an Animal Model for Coronary Atherosclerosis. Journal of Atherosclerosis and Thrombosis. 2018. 25. 5. 393-404
Shohei Tamura, Yui Koike, Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Ryosuke Nagasaka, Tetsuto Tsunoda, Motoo Tori, Kazuo Ogawa, Takeshi Bamba, et al. Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits). European journal of pharmacology. 2018. 822. 147-153

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MISC (19)：

Shiomi Masashi, 小池智也. トランスレーショナル・リサーチにおける動物種選択の重要性遺伝子組換えマウスはかならずしも万能ではない. 医学のあゆみ. 2015. 252. 3. 270-272
Masashi Shiomi, Tomonari Koike, Takashi Ito. Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins. ATHEROSCLEROSIS. 2013. 231. 1. 39-47
Shiomi Masashi, Ishida Tatsuro, Hirata Kenichi, Ito Takashi. 急性心筋梗塞症のメカニズムに迫る臨床病理と動物モデルから動脈硬化性プラーク不安定化・破綻の原因を探る冠動脈病変破綻におけるMMP陽性マクロファージとスパズムの役割. 日本動脈硬化学会総会プログラム・抄録集. 2012. 44回. 146
Tsutomu Kobayashi, Takashi Ito, Masashi Shiomi. Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2011. Vol. 2011, No. 1, pp. 406473-4
Masashi Shiomi, Takashi Ito. The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: A tribute to the late Dr. Yoshio Watanabe. ATHEROSCLEROSIS. 2009. 207. 1. 1-7

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Books (6)：

動物/疾患モデルの作製技術・病態解析・評価手法 / 脂質異常症モデル動物における系統維持と治療薬開発
(株)技術情報協会 2017
疾患モデル動物の作製と利用、脂質代謝異常と関連疾患 / WHHLMIウサギ
株式会社エル・アイ・シー 2015
Lipoproteins - Role in Health and Diseases / Genetically Modified Animal Models for Lipoprotein Research
University Campus STeP Ri 2012
Rabbit Biotechnology: Rabbit genomics, transgenesis, cloning and models / Rabbit as a Model for the Study of Human Diseases
Springer Science + Buisiness Media 2009
血管保護の新戦略 / 血管障害動物モデル
ライフ・サイエンス 2007

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Lectures and oral presentations (182)：

Identification of novel lipid markers for coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia.
(XVIIIth International Symposium on Atherosclerosis 2018)
Development of markers for progression of coronary plaques using WHHLMI rabbits, an animal model of familial hypercholesterolemia.
(86th EAS Congress 2018)
Progression of Calcific Aortic Valve Sclerosis in WHHL Rabbits, an Animal Model of Aortic Valve Stenosis
(American Heart Association Scientific sessions 2017 2017)
Does arteriosclerotic lesion regress by lipid lowering therapy? - Histopathological examination using WHHL rabbit
(65th Annual Scientific Session of the Japanese College of Cardiology 2017)
Effects of DPP4 inhibitor linagliptin on atherosclerotic lesions in Watanabe heriatble hyperlipidemic rabbit
(ESC 2017 Congress 2017)

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Education (1)：

- 1979 Obihiro University of Agriculture and Veterinary Medicine Grduate School of Agriculture and Veterinary Medicine

Professional career (2)：

農学修士 (帯広畜産大学)
獣医学博士 (麻布大学)

Committee career (4)：

日本ウサギバイオサイエンス研究会幹事
関西実験動物研究会幹事
日本動脈硬化学会評議員
日本実験動物学会評議員

Awards (5)：

2012/05 - 80th Europian Atherosclerosis Society Congress ・・Best poster award Coronary Plaque Rupture, Relation of MMP-Positive Macrophages and Coronary Spasm
2005/11 - 日本核医学会第二回日本核医学会研究奨励賞・最優秀賞 18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study
2005/06 - The Society of Nuclear Medicine 2004 First Place Award Outstanding Basic Science Investigations 18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study
2005/06 - The Society of Nuclear Medicine 2004 First Place Award Outstanding Basic Science Investigations 18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study
2005/04 - 第93回日本泌尿器科学会総会第93回日本泌尿器科学会総会賞過活動膀胱(OAB)の発症メカニズムに関する研究-WHHLウサギを用いての検討-

Association Membership(s) (6)：

日本ウサギバイオサイエンス研究会 , 関西実験動物研究会 , 日本実験動物技術者協会 , 日本循環器学会 , 日本動脈硬化学会 , 日本実験動物学会

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