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J-GLOBAL ID：201802253268621658   Reference number：18A0421614

Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits)

家族性高コレステロール血症の動物モデル(WHHLMIウサギ)における脂質代謝に対する新しく開発された化合物,D47の改善効果【Powered by NICT】

Author (12)： Tamura Shohei (Division of Comparative Pathophysiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Koike Yui (Institute for Experimental Animals, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Takeda Hiroaki (Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Koike Tomonari (Institute for Experimental Animals, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Izumi Yoshihiro (Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Nagasaka Ryosuke (Division of Comparative Pathophysiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Tsunoda Tetsuto (Medical Chemistry, Faculty of Pharmaceutical Science, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan) ,  Tori Motoo (Medical Chemistry, Faculty of Pharmaceutical Science, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan) ,  Ogawa Kazuo (Medical Chemistry, Faculty of Pharmaceutical Science, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan) ,  Bamba Takeshi (Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Shiomi Masashi (Division of Comparative Pathophysiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan) ,  Shiomi Masashi (Institute for Experimental Animals, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan)
Material： European Journal of Pharmacology  (Eur J Pharmacol)
Volume： 822  Page： 147-153  Publication year： 2018 
JST Material Number： B0841A  ISSN： 0014-2999  CODEN： EJPHAZ  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Improvements induced in lipid ...

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Thesaurus term： phosphatidylethanolamine ,  ceramide ,  gene expression ,  Atherosclerosis ,  *Lipid Metabolism ,  *lipid ,  lecithin ,  triglyceride ,  VLDL ,  Plasma ,  PPAR gamma ,  lysolecithin ,  serum lipid ,  mRNA expression ,  *Models, Animal ,  molecular genetic phenomenon

Author keywords (6)： Adipose tissue accumulation ,  Gene expression ,  D-47 ,  Lipid-lowering effects ,  Lipidome analyses ,  Liver lipid contents

JST classification (1)： Basic research of drugs acting on lipid metabolism  (GW13040M)

Terms in the title (7)： 家族性高コレステロール血症 ,  動物 ,  モデル ,  ウサギ ,  脂質代謝 ,  開発 ,  改善効果