Research keywords (8):
肝癌
, 脂肪肝
, 胆汁うっ滞
, 胆汁酸
, コレステロール
, Hepatoma
, Bile Acids
, Cholesterol
Research theme for competitive and other funds (32):
2023 - 2027 Mechanism of sarcopenia development mediated by skeletal muscle bile acid receptors using a mouse model with human-like bile acid composition
2023 - 2026 Low FODMAP food in irritable bowel syndrome and the involvement of small bowel bacterial overgrowth
2022 - 2025 胆汁酸ヒト化マウスを用いたNAFL/NASH/HCC進展メカニズムの解明
2022 - 2025 低用量アスピリンによる小腸粘膜障害発症メカニズムの解明とリスク予測法の開発
2022 - 2025 分岐鎖アミノ酸代謝物マイオカインの血糖上昇作用機序の解明
2022 - 2025 膵切除術後非アルコール性脂肪性肝疾患の病態解明と血清バイオマーカーの開発
2021 - 2025 The influence of 27-hydroxycholesterol on the deterioration of pathology in the lung cancer complicated with interstitial pneumonia
2021 - 2024 糞便ステロイドミクス解析による腸管ディスバイオーシスの新しい評価方法の開発
2020 - 2023 肝硬変患者における骨格筋代償能の血液生化学的評価法の開発
2019 - 2022 Development of evaluation method for the three major nutrient utilization state during exercise using saliva sample
2018 - 2021 Serum bile acid analysis of patients with Clostridium difficile -associated diarrhea
2018 - 2021 Comparative effect of ursodeoxycholic acid and more hydrophilic bile acids on hepatoprotection
2018 - 2021 Effects of biliary oxysterols on the growth of bile duct cancer
2018 - 2021 The promotion effect of 27-hydroxycholesterol as selective estrogen receptor modulator on the proliferation of lung cancer
2017 - 2020 Production and phenotype analysis of mouse models with humanized bile acid composition
2016 - 2020 Association of oxysterol imbalance in disease progression of non alcoholic steathepatitis
2017 - 2019 Different Amino Acids Quality and Quantity and Metabolic Syndrome: Interaction between Bile Acids and Microbiota
2016 - 2019 Involvement of amino acid metabolite in skeletal muscle on the onset of exercise-induced central fatigue
2015 - 2018 Serum metabolomics analysis of patients with fatty liver due to undernutrition
2015 - 2018 Retention of acetylcarnitine in chronic kidney disease causes insulin resistance in skeletal muscle
2015 - 2018 The actions of BCAA intermediates as myokines on hepatic metabolism
2015 - 2018 Identification of bile acid 6beta-hydroxylase in mouse liver
2014 - 2017 Application of serum bile acid profile as a new marker for gut microbiota
2014 - 2016 The relationship between vitamin D signaling and bile acid metabolism in obesity mice.
2013 - 2016 Serum lipid biomarker for the prediction of non-B, non-C liver cancer development
2012 - 2015 Development of new biomarkers for small intestinal malabsorption
2011 - 2015 Invasive metabolic markers for evaluation of host factor on the pathological progress of hepatitis C patients
2011 - 2013 Metabolite profiling of biological steroids in pathological tissue specimen
2010 - 2012 Non-invasive measurement of serum lipid metabolism biomarkers in patients with HCV infection
2008 - 2010 Screening of inherited diseases with abnormal sterol metabolism by LC-MS/MS
2003 - 2006 Prevention of hepato-carcinogenesis by endogenous steroids
2000 - 2006 Regulation of cholesterol and bile acid metabolism by nuclear receptors
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Papers (164):
Mirei Kanzaki, Akira Honda, Yasumasa Sawai, Kiyoka Suda, Ayumi Suda, Yasuhiro Kawachi. Lenvatinib-induced pyoderma gangrenosum in a patient with hepatocellular carcinoma: A case report. The Journal of dermatology. 2023
Teruo Miyazaki, Hajime Ueda, Tadashi Ikegami, Akira Honda. Upregulation of Taurine Biosynthesis and Bile Acid Conjugation with Taurine through FXR in a Mouse Model with Human-like Bile Acid Composition. Metabolites. 2023. 13. 7
Maho Yamashita, Akira Honda, Shin Shimoyama, Masahiro Umemura, Kazuyoshi Ohta, Takeshi Chida, Hidenao Noritake, Nobuhito Kurono, Mayuko Ichimura-Shimizu, Koichi Tsuneyama, et al. Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis. Journal of autoimmunity. 2023. 136. 103027-103027
Yoichi Takimoto, Po-Sung Chu, Nobuhiro Nakamoto, Yuya Hagihara, Yohei Mikami, Kentaro Miyamoto, Rei Morikawa, Toshiaki Teratani, Nobuhito Taniki, Sota Fujimori, et al. Myeloid TLR4 signaling promotes post-injury withdrawal resolution of murine liver fibrosis. iScience. 2023. 26. 3. 106220-106220
Wataru Aoi, Ryo Inoue, Katsura Mizushima, Akira Honda, Marie Björnholm, Tomohisa Takagi, Yuji Naito. Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation. iScience. 2023. 26. 3. 106251-106251
Roles of bile acids in hepatobiliary diseases: a novel approach using mouse models with humanized bile acid composition.
(International Symposium JDDW 2019 2019)
Salivary analysis of valine intermediate 3-hydroxyisobutyrate that is a possible marker of muscular BCAA utilization for energy production in exercise.
(24th Annual Congress of the European College of Sport Science. 2019)
Effect of aerobic exercise on plasma 3-Hydroxyisobutyrate level in overweight and obese men. -Comparison between non-IR, pre-IR and IR-.
(24th Annual Congress of the European College of Sport Science. 2019)
The effects of taurine depletion on bile acid composition and its amino acid-conjugation in the bile of cats.
(Experimental Biology 2019 2019)
Dietary protein quality and quantity changed energy metabolism via liver and intestine interactions signals.
(Falk Symposium 211 2018)
- 1992 University of Tsukuba Graduate School, Division of Medicine Biochemistry
1980 - 1986 University of Tsukuba
- 1986 University of Tsukuba School of Medicine
Professional career (1):
Doctor(Medical Science) (University of Tsukuba)
Work history (5):
2007/04 - 現在 Tokyo Medical University
2002/03 - 2007/03 Ibaraki Prefectural Institute of Public Health
1997/11 - 2002/02 盡誠会宮本病院
1993/10 - 1997/10 米国ニュージャージ医科歯科大学肝臓センター
1986/04 - 1988/03 University of Tsukuba University Hospital
Committee career (4):
2023/01 - 現在 Society of Bile Acid Research President
2018/10 - 現在 The Japan Society of Hepatology 肝臓専門医試験委員会委員
2018/10 - 現在 The Japan Society of Hepatology Associate Editor of the Hepatology Research
2017/07 - 現在 American Society for Biochemistry and Molecular Biology (ASBMB) Editorial Board Member of the Journal of Lipid Research
Awards (1):
2002 - 臨床胆汁酸研究会 ウルソ賞
Association Membership(s) (9):
日本抗加齢医学会
, 日本予防医学会
, THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
, JAPANESE SOCIETY FOR INHERITED METABOLIC DISEASES
, THE JAPAN SOCIETY FOR MEDICAL EDUCATION
, 日本胆道学会
, 日本肝臓学会
, 日本消化器病学会
, 日本内科学会