Rchr

J-GLOBAL ID：200901031293587990 Update date: Nov. 12, 2024

Saegusa Hironao

サエグサヒロナオ | Saegusa Hironao

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Neuroscience - general

Research keywords (3)：神経変性疾患 , ミクログリア , Caチャネル

Research theme for competitive and other funds (7)：

2015 - 現在ミクログリアCaチャネルの神経変性疾患における役割
2015 - 2017 ミクログリアCaチャネルの神経変性疾患における役割
2009 - 2011 Mechanism and physiological role for generation of the carboxyl terminal fragment of the P/Q-type calcium channel
2002 - 2002 発作性失調症2型モデルマウスを用いた発症機構の解明と遺伝子治療の試み
2001 - 2002 P/Q型CaチャネルをN型Caチャネルに置換したマウスの作製

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Papers (36)：

Saegusa Hironao, Li Xu, Wang Xinshuang, Kayakiri Midori, Tanabe Tsutomu. Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+)channel ameliorates behavioral deficits in a mouse model of Parkinson's disease. FEBS LETTERS. 2020
Huntula, S, Wang, X, Saegusa, H, Tanabe, T. Involvement of N-type Ca2+ channel in microglial activation and its implications to aging-induced exaggerated cytokine response. Cell Calcium. 2019. 82. 102059
Wang, X, Saegusa, H, Huntula, S, Tanabe, T. Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson’s disease model. Scientific Reports. 2019. 9. 9138
Daisuke Kondo, Hironao Saegusa, Tsutomu Tanabe. Involvement of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin/peroxisome proliferator-activated receptor γ pathway for induction and maintenance of neuropathic pain. Biochemical and Biophysical Research Communications. 2018. 499. 2. 253-259
Hironao Saegusa, Tsutomu Tanabe. N-type voltage-dependent Ca2+ channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. Biochemical and Biophysical Research Communications. 2014. 450. 1. 142-147

ｍore...

MISC (3)：

T. Tanabe, H. Saegusa, M. Wakamori, Y. Matsuda, J. Wang, Y. Mori, S. Zong. Functional analysis of spinocerebellar ataxia type 6 knock-in mice. JOURNAL OF NEUROCHEMISTRY. 2007. 102. 227-227
融衆太, 石川欽也, 水沢英洋, 村越隆之, 三枝弘尚, 小山内実, 田辺勉, 藤ケ崎浩人, 内原俊記. SCA6におけるCAGリピート異常伸長のα1A-Caチャネル機能への影響. 臨床神経学. 2000. 40. 12. 1342-1342
三枝弘尚, 栗原崇, 宗淑琴, 美野輪治, 韓文華, 山中ひとみ, 野田哲生, 田邊勉. イオンチャネル研究の最前線 α1EタイプCaチャネルは痛覚伝達に関与する. 生化学. 1999. 71. 8. 593-593

Books (1)：

Pharmacology of Calcium Channels
Kluwer Academic / Plenum Publishers 2004

Education (2)：

- 1993 Nagoya University Graduate School, Division of Natural Science
1984 - 1988 The University of Tokyo Faculty of Science

Professional career (1)：

Ph.D (Nagoya University)

Work history (3)：

2018/04/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Cognitive and Behavioral Medicine Pharmacology and Neurobiology Assistant Professor
1900/01/01 - 2018/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Cognitive and Behavioral Medicine Pharmacology and Neurobiology Assistant Professor
1993/04/01 - 1996/06/30 (財)神奈川科学技術アカデミー研究員

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