Research field (3)：
Pharmacology
, Allergies and connective tissue disease
, Infectious disease
Research keywords (3)：
Neutrophil
, Autoimmune disorders
, infection
Research theme for competitive and other funds (15)：
2021 - 2024 感染時にみられる好中球のエネルギー産生の場の変更機構の解明
2018 - 2021 Elucidation of the mechanisms of neutrophil mitochondrial fusion in infection
2013 - 2016 Roles of ARFs in superoxide production and chemotaxis of neutrophil
2009 - 2011 Roles of GBF1 in cell migration of neutrophil
2007 - 2008 Roles of ARF in polarity formation during cell migration
2004 - 2005 Roles played by Arf6 in cell migration and invasion
2001 - 2001 新規パキシリン結合タンパク質PAG1の細胞運動における役割
2000 - 2001 Role of paxillin-associatcd ARFGAPs in cell migration.
2000 - 2001 マクロファージの泡沫化に関わる分子の検索および解析
1999 - 2001 インテグリンを介する細胞接着シグナル制御と癌化細胞の生存性・侵潤能の解析
2000 - 2000 インテグリンを介する細胞接着シグナル制御と癌化細胞の生存性・浸潤能の解析
1999 - 2000 インテグリン裏打ちタンパク質パキシリンの細胞内輸送過程
1999 - 1999 上皮細胞における細胞接着を介した生存性シグナルの解析
1998 - 1999 Role of paxillin isoforms and their tyrosine phosphorylation in cell migration.
1998 - 1998 細胞接着制御因子パキシリンの細胞周期M期特異的変化の分子機構の解析
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Papers (39)：
Takahiro Horinouchi, Yuichi Mazaki, Soichi Miwa. Mechanism of cytotoxicity induced by the cigarette smoke extract (CSE) of heated tobacco products in vascular smooth muscle cells: A comparative study of the cytotoxic effects of CSE and the ferroptosis inducer, erastin. Journal of Pharmacological Sciences. 2023
Yuichi Mazaki, Haruka Handa, Yoshizuki Fumoto, Takahiro Horinouchi, Yasuhito Onodera. LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity. Cell communication and signaling : CCS. 2023. 21. 1. 300-300
真崎雄一, 半田悠, 麓佳月. Role of LRRK2 on neutrophil chemotaxis upon fMLP stimulation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
Mazaki Yuichi, Higashi Tsunehito, Nio-Kobayashi Junko, Onodera Yasuhito. Roles of MFN2 and MFN2 associated protein in chemotaxis of neutrophil-like differentiated HL-60 cells. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 96. 2-B-P-112
Horinouchi Takahiro, Mazaki Yuichi, Miwa Soichi. Carbonyl compounds in the gas phase extract of mainstream smoke derived from heat-not-burn and combustion cigarettes cause vascular endothelial dysfunction. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 2-P-143
Higashi Tsunehito, Mai Yosuke, Mazaki Yuichi. Molecular effects of cigarette smoke on airway epithelium cells. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 1-P-076
Higashi Tsunehito, Mai Yosuke, Mazaki Yuichi. Cigarette smoke gas phase induces ferroptosis via PKC in tracheal epithelial cells. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 96. 2-B-P-113
