Art

J-GLOBAL ID：202102240100230546   Reference number：21A0168796

Cigarette Smoke Extract and Its Cytotoxic Factor Acrolein Inhibit Nitric Oxide Production in Human Vascular Endothelial Cells

タバコ煙抽出物とその細胞毒性因子アクロレインはヒト血管内皮細胞における一酸化窒素産生を抑制する

Author (4)： Horinouchi Takahiro (Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University) ,  Mazaki Yuichi (Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University) ,  Terada Koji (Department of Biochemistry and Molecular Biology, Shiga University of Medical Science) ,  Miwa Soichi (Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 11  Page： 1804-1809(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： aerosol (suspended solids) ,...
Semi thesaurus term： tobacco smoke ,...

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Author keywords (12)： acrolein ,  cigarette smoke extract ,  endothelial nitric oxide synthase ,  nitric oxide ,  endothelial dysfunction ,  oxidative stress ,  acrolein ,  cigarette smoke extract ,  endothelial nitric oxide synthase ,  nitric oxide ,  endothelial dysfunction ,  oxidative stress

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Toxicity of chemical substances in general  (GZ02010C)

Substance index (1)： Acrolein

Reference (22)：

• 1) IARC. Tabacco smoke and involuntary smoking. IARC Monogr. Eval. Carcinog. Risks Hum., 83, 1-1438 (2004).
• 2) Smith CJ, Fischer TH. Particulate and vapor phase constituents of cigarette mainstream smoke and risk of myocardial infarction. Atherosclerosis, 158, 257-267 (2001).
• 3) Horinouchi T, Higashi T, Mazaki Y, Miwa S. Carbonyl compounds in the gas phase of cigarette mainstream smoke and their pharmacological properties. Biol. Pharm. Bull., 39, 909-914 (2016).
• 4) Noya Y, Seki K, Asano H, Mai Y, Horinouchi T, Higashi T, Terada K, Hatate C, Hoshi A, Nepal P, Horiguchi M, Kuge Y, Miwa S. Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity. Toxicology, 314, 1-10 (2013).
• 5) Asano H, Horinouchi T, Mai Y, Sawada O, Fujii S, Nishiya T, Minami M, Katayama T, Iwanaga T, Terada K, Miwa S. Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase. J. Pharmacol. Sci., 118, 275-287 (2012).

Terms in the title (8)： タバコ煙 ,  抽出物 ,  細胞毒 ,  性因子 ,  アクロレイン ,  ヒト ,  血管内皮細胞 ,  一酸化窒素