Rchr
J-GLOBAL ID：200901036341910628   Update date: Apr. 24, 2024

TAKU KASHIYAMA

カシヤマ タク | TAKU KASHIYAMA
Affiliation and department：
Juntendo University Faculty of Medicine

About Juntendo University Faculty of Medicine


Job title： Assistant Professor
Research field  (1)： Pharmacology
Research keywords  (4)： BACE1 ,  アミロイドβ ,  アルツハイマー病 ,  pharmacology
Research theme for competitive and other funds  (9)：
  • 2023 - 2026 変性神経突起における輸送障害とアルツハイマー病初期病態進展機序の解明
  • 2019 - 2023 APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明
  • 2012 - 2015 Analysis of relationship between neuregulin-cleavage and activity upon myelination by using visualization tecnique
  • 2011 - 2015 Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment
  • 2011 - 2012 Application of a cell-free protein display technology to the high-throughput functional proteomic screen for regulators of neuron-glia interaction
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Papers (30)：
  • Ritsuko Sasaki, Nagomi Kurebayashi, Hidetaka Eguchi, Yoshiya Horimoto, Takahiro Shiga, Sakiko Miyazaki, Taku Kashiyama, Wado Akamatsu, Mitsue Saito. Involvement of kallikrein-PAR2-proinflammatory pathway in severe trastuzumab-induced cardiotoxicity. Cancer science. 2022. 113. 10. 3449-3462
  • 佐々木 律子, 呉林 なごみ, 江口 英孝, 堀本 義哉, 志賀 孝宏, 宮崎 彩記子, 樫山 拓, 赤松 和土, 齊藤 光江. 患者iPS細胞由来心筋細胞モデルを用いたTrastuzumab心毒性発現メカニズムの解明. 日本乳癌学会総会プログラム抄録集. 2022. 30回. OS7-4
  • Ritsuko Sasaki, Nagomi Kurebayashi, Hidetaka Eguchi, Yoshiya Horimoto, Takahiro Shiga, Sakiko Miyazaki, Taku Kashiyama, Wado Akamatsu, Mitsue Saito. Elucidation of the mechanisms of trastuzumab-induced severe cardiotoxicity using patient-derived iPSCs cardiomyocyte model. Journal of Clinical Oncology. 2022. 40. 16_suppl. e24065-e24065
  • Nanaka Kaneshiro, Ryosuke Imaoka, Masato Komai, Taku Kashiyama, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi. Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells. Biochemical and biophysical research communications. 2018. 501. 4. 1023-1028
  • Nobumasa Takasugi, Runa Araya, Yuji Kamikubo, Nanaka Kaneshiro, Ryosuke Imaoka, Hao Jin, Taku Kashiyama, Yoshie Hashimoto, Masaru Kurosawa, Takashi Uehara, et al. TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes. PloS one. 2018. 13. 8. e0200988
ｍore...
MISC (59)：
ｍore...
Professional career (2)：
  • (BLANK) (Chiba University)
  • (BLANK) (Chiba University)
Association Membership(s) (1)：
日本薬理学会
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