Art

J-GLOBAL ID：201802246833292488   Reference number：18A1035648

Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells

神経2A細胞におけるゲノム編集によるマウスAPPの膜内外ドメインの機能解析【JST・京大機械翻訳】

Author (8)： Kaneshiro Nanaka (Department of Medical Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan) ,  Imaoka Ryosuke (Department of Medical Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan) ,  Komai Masato (Department of Medical Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan) ,  Kashiyama Taku (Department of Cellular and Molecular Pharmacology, Juntendo University, Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Sakurai Takashi (Department of Cellular and Molecular Pharmacology, Juntendo University, Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Uehara Takashi (Department of Medical Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan) ,  Takasugi Nobumasa (Department of Medical Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan) ,  Takasugi Nobumasa (Department of Cellular and Molecular Pharmacology, Juntendo University, Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 501  Issue： 4  Page： 1023-1028  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Amyloid-β precursor protein (A...

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Thesaurus term： metabolite ,  *amyloid beta-protein ,  precursor (substance) ,  pathogenesis ,  differentiation (biology) ,  enzyme ,  Tubulin ,  Alzheimer Disease ,  clone ,  neuron ,  repressor ,  axon growth ,  neural differentiation ,  *domain structure ,  *Nerve ,  *Amyloid ,  *glycoprotein ,  *animal protein ,  Proteins

Author keywords (4)： Alzheimer disease ,  Amyloid beta ,  Amyloid precursor protein ,  Neurite outgrowth

JST classification (4)： Cell physiology in general  (EF02010S) ,  Nervous system diseases  (GN03000O) ,  Basic neurology  (GN01020W) ,  Proteins and peptides in general  (EB03010N)

Terms in the title (6)： 神経 ,  ゲノム編集 ,  マウス ,  APP ,  ドメイン ,  機能解析