Research field (4)：
Immunology
, Functional biochemistry
, Structural biochemistry
, Molecular biochemistry
Research keywords (5)：
RNP
, RNA binding protein
, posttranscriptional regulation
, 免疫学
, iron homeostasis
Research theme for competitive and other funds (6)：
2019 - 2023 Sortilinの新規リガンド分泌機構の分子基盤とその好酸球における役割
2016 - 2019 生体金属イオンシグナルによる新規サイトカイン産生制御機構の解明
2013 - 2015 TLR9シグナルの新規制御分子Sortilinの機能解析
2013 - 2014 TLR9シグナルの新規制御分子Sortilinの機能解析
2008 - 2009 The structural basis of the Fe-S cluster biosynthesis
iron homeostasis
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Papers (21)：
Xinquan Yang, Toshiki Yabe-Wada, Jia Han, Fumiji Saito, Chie Ogasawara, Sohsuke Yamada, Nobuyuki Onai. PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon. International Immunology. 2023
Honoka Watanabe, Toshiki Yabe-Wada, Nobuyuki Onai, Masaki Unno. Detailed Structure of Mouse Interferon α2 and Its Interaction with Sortilin. The Journal of Biochemistry. 2021
Toshiki Yabe-Wada, Caroline C Philpott, Nobuyuki Onai. PCBP2 posttranscriptionally regulates sortilin expression by binding to a C-rich element in its 3′ UTR. FEBS Open Bio. 2020. 10. 3. 407-413
Toshiki Yabe-Wada, Shintaro Matsuba, Kazuya Takeda, Akira Nakamura, Caroline C. Philpott, Nobuyuki Onai. Involvement of poly-rC binding proteins in posttranscriptional regulation of Sortilin, the cytokine trafficking mediator. CYTOKINE. 2017. 100. 145-146
Sebastien Leidgens, Kimberley Bullough, Haifeng Shi, Toshiki Yabe, Minoo Shakoury-Elizeh, Poorna Subramanian, Emory Hsu, Navin Natarayan, Anjali Nandal, Timothy Stemmler, et al. EACH MEMBER OF THE PCBP FILY EXHIBITS IRON CHAPERONE ACTIVITY TOWARD FERRITIN. AMERICAN JOURNAL OF HEMATOLOGY. 2013. 88. 5. E20-E20
Anjali Nandal, Avery Frey, Jong-Hwan Park, Toshiki Yabe, Myung-Hee Park, Caroline Philpott. ACTIVATION OF THE ESSENTIAL DIIRON ENZYME DEOXYHYPUSINE HYDROXYLASE BY THE IRON CHAPERONES PCBP1 AND PCBP2. AMERICAN JOURNAL OF HEMATOLOGY. 2013. 88. 5. E197-E197
