Ohshima Toshio

オオシマトシオ | Ohshima Toshio

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.ohshima.biomed.sci.waseda.ac.jp/

Research field (2)： Neuroanatomy and physiology , Neuroscience - general

Research theme for competitive and other funds (10)：

2022 - 2025 Study on the role of CRMP2 phosphorylation in neural circuit formation and regeneration
2018 - 2023 Cross-talk between endocrine and environmental factors in neuroimmune disorders
2018 - 2021 CRMPをターゲットとした神経損傷・神経変性疾患治療戦略開発
2014 - 2017 Elucidation of roles of CRMP in neural circuit formation and regeneration and application for the treatment of spinal cord injury
2009 - 2011 Functional analysis of Cdk5 by using conditional KO of its activating subunit p35

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Papers (114)：

Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, et al. Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis. Frontiers in neurology. 2022. 13. 994676-994676
Miyuki Takahashi, Toshiyuki Takasugi, Arisa Kawakami, Ran Wei, Kanae Ando, Toshio Ohshima, Shin-ichi Hisanaga. Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice. Neurochemical Research. 2022. 47. 9. 2773-2779
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima. Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons. MOLECULAR BRAIN. 2022. 15. 1
Yuki Yamazaki, Maho Moizumi, Jun Nagai, Yoshiki Hatashita, Tianhong Cai, Papachan Kolattukudy, Takafumi Inoue, Yoshio Goshima, Toshio Ohshima. Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4. Cerebral cortex (New York, N.Y. : 1991). 2022. 32. 3. 520-527
Hiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Kenya Sato, et al. Recent Advances in the Modeling of Alzheimer's Disease. Frontiers in neuroscience. 2022. 16. 807473-807473

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MISC (5)：

M. Takahashi, M. Ishida, T. Saito, H. Kobayashi, A. Kawakami, T. Takasugi, T. Ohshima, S. Hisanaga. Effect of valproic acid on Cdk5 activity and mouse behavior. JOURNAL OF NEUROCHEMISTRY. 2014. 130. 37-37
Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Masahiko Taniguchi, Toshio Ohshima, Yoshio Goshima. Sema3A regulates apical dendritic growth of hippocamal CA1 pyramidal neurons. NEUROSCIENCE RESEARCH. 2009. 65. S46-S46
Yoko Ito, Hideomi Tanaka, Hitoshi Okamoto, Toshio Ohshima. Expression profiling of neural stem cell markers in dividing cells of the adult zebrafish optic tectum. NEUROSCIENCE RESEARCH. 2008. 61. S169-S169
Naoya Yamashita, Asa Morita, Yutaka Uchida, Toshio Ohshima, Fumio Nakamura, Jerome Honnorat, Pappachan Kolattukudy, Yoshio Goshima. CRMP1 regulates spine maturation through mediating Semaphorin3A signaling in vivo. NEUROSCIENCE RESEARCH. 2007. 58. S204-S204
Yutaka Uchida, Toshio Ohshima, Naoya Yamashita, Fumio Nakamura, Papachan Kolattukudy, Jerome Honnorat, Yoshio Goshima. Phosphorylation of CRMP2 at S522 is required for proper dendritic patterning of layer V cortical neurons in vivo. NEUROSCIENCE RESEARCH. 2007. 58. S203-S203

Books (1)：

Cyclin Dependent Kinase5
Spriger 2008 ISBN:9780387788869

Lectures and oral presentations (1)：

Requirement of Cdk5 for proper cerebellar development and function
(2nd international symposium on Cdk5 Tokyo 2009)

Professional career (1)：

MD, PhD (Yamanashi Medical University)

Awards (1)：

2001 - 日本神経化学会奨励賞

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