Rchr
J-GLOBAL ID：200901040547533704   Update date: May. 20, 2025

Kobayashi Kaoru

Kobayashi Kaoru
Affiliation and department：
Meiji Pharmaceutical University Department of Biopharmaceutics

About Meiji Pharmaceutical University Department of Biopharmaceutics


Job title： Professor
Research field  (1)： Clinical pharmacy
Research keywords  (1)： Drug Metabolism
Research theme for competitive and other funds  (30)：
  • 2022 - 2027 染色体工学技術を用いたヒト化モデル動物・細胞による創薬支援
  • 2023 - 2026 Effect of diet on biotransformation and individual differences in drug metabolism
  • 2022 - 2025 B型肝炎ウイルス持続感染実験モデルを用いた病態解明及び新しい治療法の開発に資する研究 分担課題 シーズ化合物の体内動態解析
  • 2019 - 2022 Basic research on individualized drug therapy based on CYP3A5 genetic information
  • 2017 - 2021 次世代抗B型肝炎ウイルス薬導出に向けた創薬研究 分担課題名;新規HBVcccDNA阻害薬の体内動態解析
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Papers (102)：
  • Miki Nakajima, Hiroshi Yamazaki, Kouichi Yoshinari, Kaoru Kobayashi, Yuji Ishii, Daisuke Nakai, Hidetaka Kamimura, Toshiyuki Kume, Yoshiro Saito, Kazuya Maeda, et al. Contribution of japanese scientists to drug metabolism and disposition. Drug metabolism and disposition. 2025. 100071-100071
  • Genki Minegishi, Yuka Kobayashi, Mayu Fujikura, Ayane Sano, Yasuhiro Kazuki, Kaoru Kobayashi. Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics. Pharmacology research & perspectives. 2024. 12. 3. e1197
  • Yang Li, Yasuhiro Kazuki, Thomas Drabison, Kaoru Kobayashi, Ken-Ichi Fujita, Yue Xu, Yan Jin, Eman Ahmed, Junan Li, Eric D Eisenmann, et al. Vincristine disposition and neurotoxicity are unchanged in humanized CYP3A5 mice. Drug Metabolism and Disposition. 2024. 52. 2. 80-85
  • Yutaka Furutani, Yoshinori Hirano, Mariko Toguchi, Shoko Higuchi, Xian-Yang Qin, Kaori Yanaka, Yumi Sato-Shiozaki, Nobuaki Takahashi, Marina Sakai, Pornparn Kongpracha, et al. A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor. Cell Death Discovery. 2023. 9. 1. 467-467
  • Kiamu Kurosawa, Masataka Nakano, Itsuki Yokoseki, Mai Nagaoka, Seiya Takemoto, Yoshiyuki Sakai, Kaoru Kobayashi, Yasuhiro Kazuki, Tatsuki Fukami, Miki Nakajima. ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver. Biochemical Pharmacology. 2023. 115733-115733
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MISC (190)：
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Patents (5)：
Books (7)：
  • 生物薬剤学 改訂第4版
    南江堂 2024
  • 生物薬剤学 改訂第3版
    2015
  • P450の分子生物学 第2版
    2009
  • 分子薬物動態学
    2008
  • P450の分子生物学
    講談社サイエンティフィク 2003
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Lectures and oral presentations  (35)：
  • Species differences and individual variability in drug metabolism
    (2023 ICCP450/JSSX International Joint meeting 2023)
  • ヒト化動物を用いた薬物代謝・動態研究への応用
    (第10回実験動物科学シンポジウム 2022)
  • Evaluation of intestinal metabolism in humanized animals
    (2021)
  • 薬物動態関連ヒト化動物を用いた薬物代謝・薬物動態研究
    (第2回Cell Based Assay Workshop 2021)
  • 染色体工学技術により作成したヒト化動物を用いた薬物代謝研究
    (2020年度薬物動態談話会9月例会 2020)
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Education (2)：
  • 1991 - 1993 Tokyo University of Science Graduate School of Pharmaceutical Sciences
  • 1987 - 1991 Tokyo University of Science Faculty of Pharmaceutical Sciences
Professional career (1)：
  • Ph.D. (Chiba University)
Work history (5)：
  • 2020/04 - 現在 Meiji Pharmaceutical University Department of Biopharmaceutics Professor
  • 2007/04 - 2020/03 Chiba University Graduate School of Pharmaceutical Sciences Associate Professor
  • 2005/04 - 2007/03 Chiba University Graduate School of Pharmaceutical Sciences Associate Professor
  • 1997/10 - 2005/03 Chiba University Faculty of Pharmaceutical Sciences Research Associate
  • 1993/04 - 1997/09 Showa University Faculty of Pharmaceutical Sciences Research Associate
Committee career (9)：
  • 2023/12 - 現在 日本薬物動態学会 監事
  • 2023/10 - 現在 内閣府食品安全委員会 専門委員
  • 2016/01 - 現在 日本薬物動態学会 代議員
  • 2013/01 - 現在 Journal of Pharmaceutical Sciences Scientific Advisor
  • 2011/01 - 現在 Drug Metabolism and Pharmacokinetics Editorial Advisory Board
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Awards (5)：
  • 2022/11 - 日本薬物動態学会第37回年会ベストポスター賞
  • 2009 - 日本薬物動態学会 第24回日本薬物動態学会年会ベストポスター賞 Expression of drug-metabolizing enzymes in the human hepatocellular carcinoma cell line cultured on the micro-space cell culture plate.
  • 2009 - 日本薬物動態学会 2009年度DMPK最優秀論文賞 Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes.
  • 2008/10 - 日本薬物動態学会 第23回日本薬物動態学会奨励賞 核内レセプターによる薬物代謝酵素の発現制御機構に関する研究
  • 2008 - 日本薬物動態学会 第23回日本薬物動態学会年会ベストポスター賞 Humanized P450 mouse: (1) Construction of humanized model mice containing the CYP3A cluster for drug screening. Construction of humanized model mice containing the CYP3A cluster using a human artificial chromosome.
Association Membership(s) (7)：
The Japanese Society for Alternatives to Animal Experiments ,  American Society for Pharmacology and Experimental Therapeutics ,  The Japanese Pharmacological Society ,  International Society for the Study of Xenobiotics ,  The Japanese Society of Clinical Pharmacology and Therapeutics ,  The Japanese Society for the Study of Xenobiotics ,  The Pharmaceutical Society of Japan
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