Miyata Yoshihiko

ミヤタヨシヒコ | Miyata Yoshihiko

Affiliation and department：
Job title： Assistant Professor

Research field (3)： Cell biology , Molecular biology , Functional biochemistry

Research keywords (14)： Autism Spectrum Disorder , Down Syndrome , FKBP52 , DCAF7/WDR68 , FAM53C , MOK , DYRK1A , DYRK , Cdc37 , CK2 , Hsp90 , Signal Transduction , Molecular Chaperone , Protein Kinase

Research theme for competitive and other funds (33)：

2018 - 2023 Analysis of physiological function of Down syndrome-associated DYRK1A-WDR68 complex.
2013 - 2016 Analysis of physiological function of the complex between the Down syndrome kinase DYRK1A and WDR68.
2012 - 2014 Analysis of the recognition mechanism of the intrinsically disordered region of Cdc37 to signaling protein kinases.
2011 - 2013 Mechanism of the interaction of the Tau and FKBP52 proteins; applications to Tauopathies.
2011 - 2012 Analysis of cellular function of WDR68, a specific binding partner for Down-syndrome associated DYRK1A.

2008 - 2011 Identification and functional analyses of cellular proteins that specifically interact with DYRK family protein kinases.

2005 - 2007 Analysis of the Hsp90-Cdc37 molecular chaperone system that supports function of signaling protein kinases.

2005 - 2007 Analysis of cellular function of DYRK family protein kinases.

2003 - 2005 Analysis of structure and function of Cdc37 that is involved in quality control of protein kinases.

2002 - 2003 Protein quality control of signaling kinases by the Hsp90-Cdc37 molecular chaperone system.

2001 - 2003 Analysis of physiological function of a protein kinase MOK, a novel member of MAP kinase superfamily.

1999 - 2001 Identification and functional analysis of a novel MAP kinase superfamily member.

1998 - 1999 Functional analysis of MRK, a MAP kinase-related protein, in C.elegans.

1997 - 1999 高次生体システムの機能制御の研究.

1993 - 1999 Quality control mechanism of the function of oncogene products by stress proteins.

1997 - 1998 Identification and analysis of a novel MAP kinase family protein involved in celluar signal transduction.

1996 - 1997 Identification and purification of proteinous factors that control casein kinase II activity in cells.

1996 - 1997 Functional control of oncogene products by the stress protein Hsp90.

1995 - 1997 Studies of quality control of proteins in the endoplasmic reticulum.

1995 - 1996 Identification and analysis of a GRP94 kinase that is activated by nuclear translocation signal peptides.

1993 - 1995 Interaction between a stress protein HSP90 and its target proteins.

1994 - 1995 Analysis of the complex between a heat shock protein Hsp90 and an FK506 binding protein FKBP52.

1994 - 1995 Function, expression mechanism, and their control systems of heat shock/stress proteins.

1992 - 1995 Function, expression mechanism, and regulation of heat shock proteins.

1993 - 1994 Analysis of the complex between the heat shock protein Hsp90 and SV40 large T antigen.

1992 - 1994 熱ショック・ストレス蛋白質の機能、発現機構とその制御

1991 - 1994 HSP90, a stress protein which regulates functional proteins

1992 - 1993 Study on the role of a heat shock protein Hsp90 in the regulation of activity and cellular localization of casein kinase 2.

1992 - 1993 Structure and signal transduction of the Interleukin 3 receptor.

1991 - 1992 Analysis of the control mechanism of casein kinase 2 activity by the heat shock protein Hsp90.

1990 - 1991 Intracellular form of a P450-inducing drug receptor.

1990 - 1991 Analysis of the physiological function of a complex between casein kinase II and the heat shock protein Hsp90.

1989 - 1990 Intracellular form of a drug receptor that induces P450 expression.

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Papers (77)：

Yoshihiko Miyata, Eisuke Nishida. Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A. Life Science Alliance. 2023. 6. 12. e202302129-e202302129
Jesús A. Pérez-Cabello, Lucía Silvera-Carrasco, Jaime M. Franco, Vivian Capilla-González, Alexandros Armaos, María Gómez-Lima, Raquel García-García, Xin Wen Yap, Magdalena Leal-Lasarte, Deepti Lall, et al. MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS. Proceedings of the National Academy of Sciences. 2023. 120. 28
Yoshihiko Miyata, Eisuke Nishida. Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone. Biochimica et biophysica acta. Molecular cell research. 2021. 1868. 119081-119081
Hitoshi Nakamoto, Yuhei Yokoyama, Takahiro Suzuki, Yuri Miyamoto, Takashi Fujishiro, Masaaki Morikawa, Yoshihiko Miyata. A cyclic lipopeptide surfactin is a species-selective Hsp90 inhibitor that suppresses cyanobacterial growth. Journal of biochemistry. 2021. 170. 255-264
Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miyata, Masaru Hoshino. Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy. Biochimica et biophysica acta. Proteins and proteomics. 2019. 1867. 9. 813-820

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MISC (3)：

Y MIYATA, E NISHIDA, H SAKAI. GROWTH FACTOR-INDUCED AND PHORBOL ESTER-INDUCED CHANGES IN CELL MORPHOLOGY ANALYZED BY DIGITAL IMAGE-PROCESSING. CELL STRUCTURE AND FUNCTION. 1987. 12. 6. 670-670
M HOSHI, Y MIYATA, E NISHIDA, H SAKAI, H OGAWARA, T AKIYAMA. PHOSPHORYLATION OF MICROTUBULE-ASSOCIATED PROTEINS BY PURIFIED PROTEIN-KINASE-C. CELL STRUCTURE AND FUNCTION. 1986. 11. 4. 447-447
Y MIYATA, M HOSHI, E NISHIDA, H SAKAI, T KADOWAKI, M KASUGA, S KOYASU, YAHARA, I. BIOLOGICAL AND BIOCHEMICAL RESPONSES IN KB CELLS RAPIDLY INDUCED BY GROWTH-FACTORS .2. STIMULATION OF PINOCYTOSIS. CELL STRUCTURE AND FUNCTION. 1986. 11. 4. 454-454

Books (11)：

CK2 inhibitors and the DYRK family protein kinases.
“Protein Kinase CK2 Cellular Function in Normal and Disease States”, ed. K. Ahmed, O. Issinger, and R. Szyska, Advances in Biochemistry in Health and Disease, Springer International Publishing Switzerland, Vol. 12. 2015
The pivotal role of CK2 in the kinome-targeting Hsp90 chaperone machinery.
“The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2”, ed. L.A.Pinna and J. Jeffryes, Wiley-Blackwell Publishing 2013
シグナル伝達の原理と多様性. 「医学のための細胞生物学」
南山堂 2009 ISBN:4525131217
分子生物学・免疫学キ-ワ-ド辞典第二版
医学書院 2003
熱ショックタンパク質(HSP90・GRP94).
廣川タンパク質化学第六巻「細胞骨格と筋肉のタンパク質」、廣川書店(東京),139-145 1997

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Lectures and oral presentations (98)：

Identification of FAM53C as a novel regulatory binding protein of DYRK1A
(2nd International Meeting on DYRK1A, related kinases and human disease 2022)
Functional Regulation of Down Syndrome and Autism Spectrum Disorder-related DYRK family protein kinases
(2019)
Hsp90 molecular chaperone, signaling protein kinases, and cancer
(Seminar at Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg (Strasbourg, France) 2018)
Functional regulation of DYRK1A, a kinase intimately involved in Down syndrome and autism spectrum disorder, by cellular binding partners
(Seminar at Institut de Génétique et de Biologie Moléculaire et Cellulaire (Illkirch, France) 2018)
ダウン症関連キナーゼDYRKファミリーの細胞内結合分子シャペロンによる機能制御
(埼玉大学分子生物学科セミナー (埼玉) 2017)

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Education (4)：

- 1992 The University of Tokyo Graduate School of Science Awarded the degree of Ph.D. in Cell Biology and Biochemistry
1986 - 1988 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
1984 - 1986 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
1982 - 1984 The University of Tokyo College of Arts and Sciences Natural Sciences I

Professional career (1)：

Ph. D. (The University of Tokyo)

Work history (15)：

2007/04 - 現在 Kyoto University Graduate School of Biostudies, Division of Integrated Life Science, Department of Cell & Developmental Biology Assistant Professor
2019 - 2023 Ritsumeikan University College of Life Sciences & Graduate School of Life Sciences Lecturer (Non-full-time)
2017 - 2019 Saitama University Faculty of Science & Graduate School of Science and Engineering Lecturer (Non-full-time)
2018 - University of Strasbourg Institute of Genetics and Molecular and Cellular Biology Visiting Research Scientist (Faculty Exchange Program)
2014 - 2015 Vrije Universiteit Amsterdam Faculty of Medical and Natural Sciences Specially Appointed Lecturer

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Association Membership(s) (2)：

日本生化学会 , The Japanese Biochemistry Society.

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