Rchr
J-GLOBAL ID:200901040945042532   Update date: Aug. 28, 2020

Miyata Yoshihiko

ミヤタ ヨシヒコ | Miyata Yoshihiko
Affiliation and department:
Job title: Assistant Professor
Research field  (3): Cell biology ,  Molecular biology ,  Functional biochemistry
Research keywords  (13): DYRK ,  Cdc37 ,  CK2 ,  Hsp90 ,  シグナル伝達 ,  分子シャペロン ,  キナーゼ ,  DYRK ,  Cdc37 ,  CK2 ,  Signal transduction ,  Molecular Chaperone ,  Kinase
Research theme for competitive and other funds  (6):
  • 分子シャペロンHsp90を標的とするがん治療の基礎的研究
  • シグナル伝達キナーゼのクオリティーコントロールに関わるHsp90・Cdc37分子シャペロンの構造と機能の研究
  • シグナル伝達に関わる新しいMAPキナーゼ類縁タンパク質の構造と機能の解析
  • Functional and structural analysis of the Hsp90/Cdc37 molecular chaperone system that is involved in the quality control of signaling protein kinases.
  • Analysis of interaction between protein kinases and molecular chaperones
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Papers (72):
  • Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miyata, Masaru Hoshino. Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy. Biochimica et biophysica acta. Proteins and proteomics. 2019. 1867. 9. 813-820
  • Nakamoto, H, Amaya, Y, Komatsu, T, Suzuki, T, Dohmae, N, Nakamura, Y, Jantan, I, Miyata, Y. Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity. Biochemical Journal. 2018. 475. 2559-2576
  • Sandra Marmiroli, Doriano Fabbro, Yoshihiko Miyata, Mariaelena Pierobon, Maria Ruzzene. Phosphorylation, Signaling, and Cancer: Targets and Targeting. BIOMED RESEARCH INTERNATIONAL. 2015. 2015. 601543
  • B. Guerra, T. Rasmussen, A. Schnitzler, H. Jensen, B. Boldyreff, Y. Miyata, N. Marcussen, K. Niefind, O.G. Issinger. E9, a novel CK2 inhibitor interferes with HIF-1α stability, and induces necrosis in murine xenograft tumor models. Cancer Letters. 2015. 356. 751-761
  • Yoshihiko Miyata, Takeshi Shibata, Masato Aoshima, Takuichi Tsubata, Eisuke Nishida. The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp 40 (WD40) Repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A Binding, and Nuclear Accumulation. JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289. 48. 33320-33332
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MISC (3):
  • Y MIYATA, E NISHIDA, H SAKAI. GROWTH FACTOR-INDUCED AND PHORBOL ESTER-INDUCED CHANGES IN CELL MORPHOLOGY ANALYZED BY DIGITAL IMAGE-PROCESSING. CELL STRUCTURE AND FUNCTION. 1987. 12. 6. 670-670
  • M HOSHI, Y MIYATA, E NISHIDA, H SAKAI, H OGAWARA, T AKIYAMA. PHOSPHORYLATION OF MICROTUBULE-ASSOCIATED PROTEINS BY PURIFIED PROTEIN-KINASE-C. CELL STRUCTURE AND FUNCTION. 1986. 11. 4. 447-447
  • Y MIYATA, M HOSHI, E NISHIDA, H SAKAI, T KADOWAKI, M KASUGA, S KOYASU, YAHARA, I. BIOLOGICAL AND BIOCHEMICAL RESPONSES IN KB CELLS RAPIDLY INDUCED BY GROWTH-FACTORS .2. STIMULATION OF PINOCYTOSIS. CELL STRUCTURE AND FUNCTION. 1986. 11. 4. 454-454
Books (11):
  • CK2 inhibitors and the DYRK family protein kinases.
    “Protein Kinase CK2 Cellular Function in Normal and Disease States”, ed. K. Ahmed, O. Issinger, and R. Szyska, Advances in Biochemistry in Health and Disease, Springer International Publishing Switzerland, Vol. 12. 2015
  • The pivotal role of CK2 in the kinome-targeting Hsp90 chaperone machinery.
    “The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2”, ed. L.A.Pinna and J. Jeffryes, Wiley-Blackwell Publishing 2013
  • シグナル伝達の原理と多様性. 「医学のための細胞生物学」
    南山堂 2009 ISBN:4525131217
  • 分子生物学・免疫学キ-ワ-ド辞典 第二版
    医学書院 2003
  • 熱ショックタンパク質(HSP90・GRP94).
    廣川タンパク質化学 第六巻「細胞骨格と筋肉のタンパク質」、廣川書店(東京),139-145 1997
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Lectures and oral presentations  (97):
  • Functional Regulation of Down Syndrome and Autism Spectrum Disorder-related DYRK family protein kinases
    (2019)
  • Hsp90 molecular chaperone, signaling protein kinases, and cancer
    (Seminar at Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg (Strasbourg, France) 2018)
  • Functional regulation of DYRK1A, a kinase intimately involved in Down syndrome and autism spectrum disorder, by cellular binding partners
    (Seminar at Institut de Génétique et de Biologie Moléculaire et Cellulaire (Illkirch, France) 2018)
  • ダウン症関連キナーゼDYRKファミリーの細胞内結合分子シャペロンによる機能制御
    (埼玉大学 分子生物学科セミナー (埼玉) 2017)
  • Nascent chain folding process of DYRK family protein kinases
    (The 19th Symposium, Graduate School of Biostudies, Kyoto University 2017)
more...
Education (6):
  • - 1992 The University of Tokyo
  • - 1992 The University of Tokyo Cell & Molecular Biochemistry
  • - 1988 The University of Tokyo
  • - 1988 The University of Tokyo
  • - 1986 The University of Tokyo
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Professional career (1):
  • Ph. D. (The University of Tokyo)
Work history (20):
  • 2007 - 現在 Kyoto University Graduate School of Biostudies, Division of Integrated Life Science
  • 2007 - 現在 Associate Professor, Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University.
  • 1999 - 2007 Kyoto University Graduate School of Biostudies, Division of Integrated Life Science
  • 1999 - 2007 Research Associate, Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University.
  • 2005 - 神戸大学 大学院医学系研究科 非常勤講師 兼任
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Association Membership(s) (2):
日本生化学会 ,  The Japanese Biochemistry Society.
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