J-GLOBAL ID:200901040945042532   Update date: Jun. 09, 2020

Miyata Yoshihiko

ミヤタ ヨシヒコ | Miyata Yoshihiko
Affiliation and department:
Job title: Assistant Professor
Research field  (3): Cell biology ,  Molecular biology ,  Functional biochemistry
Research keywords  (6): DYRK ,  Cdc37 ,  CK2 ,  Signal transduction ,  Molecular Chaperone ,  Kinase
Research theme for competitive and other funds  (3):
  • Functional and structural analysis of the Hsp90/Cdc37 molecular chaperone system that is involved in the quality control of signaling protein kinases.
  • Analysis of interaction between protein kinases and molecular chaperones
  • Structural and functional analysis of novel families of MAP kinase-related protein kinases that are involved in cellular signal transduction systems.
Papers (52):
  • Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miyata, Masaru Hoshino. Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy. Biochimica et biophysica acta. Proteins and proteomics. 2019. 1867. 9. 813-820
  • Nakamoto, H, Amaya, Y, Komatsu, T, Suzuki, T, Dohmae, N, Nakamura, Y, Jantan, I, Miyata, Y. Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity. Biochemical Journal. 2018. 475. 2559-2576
  • Sandra Marmiroli, Doriano Fabbro, Yoshihiko Miyata, Mariaelena Pierobon, Maria Ruzzene. Phosphorylation, Signaling, and Cancer: Targets and Targeting. BIOMED RESEARCH INTERNATIONAL. 2015. 2015. 601543
  • B. Guerra, T. Rasmussen, A. Schnitzler, H. Jensen, B. Boldyreff, Y. Miyata, N. Marcussen, K. Niefind, O.G. Issinger. E9, a novel CK2 inhibitor interferes with HIF-1α stability, and induces necrosis in murine xenograft tumor models. Cancer Letters. 2015. 356. 751-761
  • Yoshihiko Miyata, Takeshi Shibata, Masato Aoshima, Takuichi Tsubata, Eisuke Nishida. The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp 40 (WD40) Repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A Binding, and Nuclear Accumulation. JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289. 48. 33320-33332
Books (4):
  • CK2 inhibitors and the DYRK family protein kinases.
    “Protein Kinase CK2 Cellular Function in Normal and Disease States”, ed. K. Ahmed, O. Issinger, and R. Szyska, Advances in Biochemistry in Health and Disease, Springer International Publishing Switzerland, Vol. 12. 2015
  • The pivotal role of CK2 in the kinome-targeting Hsp90 chaperone machinery.
    “The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2”, ed. L.A.Pinna and J. Jeffryes, Wiley-Blackwell Publishing 2013
  • Cell growth, cytoskeleton and heat shock proteins.
    Results and Problems in Cell Differentiation; Heat Shock and Development. (eds., L.Hightower and L.Nover), Springer-Verlag, Heidelberg,210-216 1991
  • HSP90, a carrier of key proteins that regulates cell function.
    Heat Shock (eds., B.Maresca, and S.Lindquist), Springer-Verlag, Heidelberg 1991
Lectures and oral presentations  (53):
  • Hsp90 molecular chaperone, signaling protein kinases, and cancer
    (Seminar at Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg (Strasbourg, France) 2018)
  • Functional regulation of DYRK1A, a kinase intimately involved in Down syndrome and autism spectrum disorder, by cellular binding partners
    (Seminar at Institut de Génétique et de Biologie Moléculaire et Cellulaire (Illkirch, France) 2018)
  • Nascent chain folding process of DYRK family protein kinases
    (The 19th Symposium, Graduate School of Biostudies, Kyoto University 2017)
  • Functional regulation of different DYRK family protein kinases by distinctive cellular binding partners
    (International Meeting on “DYRK1A, related kinases and human disease” 2017)
  • Mechanism of conformational transition of molecular chaperone Cdc37
    (Annual Meeting of 16th Protein Science Society of Japan 2016)
Education (4):
  • - 1992 The University of Tokyo Graduate School, Division of Science Cell & Molecular Biochemistry
  • - 1988 The University of Tokyo Graduate School, Division of Science
  • - 1986 The University of Tokyo Faculty of Science
  • - 1986 The University of Tokyo Faculty of Science
Professional career (1):
  • Ph. D. (The University of Tokyo)
Work history (14):
  • 2007 - 現在 Kyoto University
  • 2007 - 現在 Associate Professor, Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University.
  • 1999 - 2007 Kyoto University
  • 1999 - 2007 Research Associate, Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University.
  • 2005 - Visiting Professor, Graduate School of Medicine, Kobe University.
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Association Membership(s) (1):
The Japanese Biochemistry Society.
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