Midori Arai

アライミドリ | Midori Arai

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://keiochembio.com

Research field (3)： Pharmaceuticals - chemistry and drug development , Environmental and pharmaceutical development resources , Chemical biology

Research keywords (5)： Natural products , Chemical biology , 天然物化学 , ケミカルバイオロジー , 生物有機化学

Research theme for competitive and other funds (14)：

2023 - 2028 化合物潜在空間の深化に資する包括的活性評価と微生物由来天然物の拡充
2023 - 2025 Development of novel tau-degrading molecular glue from artificial natural product extract by protein bead method
2021 - 2024 Development of bioactive compounds by activation of cryptic genes based on invasive evolution of pathogenic microorganisms
2020 - 2023 Search for bioactive natural products with overcoming effects on cancer-heterogeneity
2017 - 2020 Search and function elucidation of highly active natural products targeting cancer microenvironmental signals

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Papers (145)：

Yukiko Ujie, Shun Saito, Tomoya Banno, Takashi Yaguchi, Midori A Arai. Co-culture of Aspergillus niger IFM 59706 and RAW264 cells enhances the production of aurasperone A with NO inhibitory activity. Bioscience, Biotechnology, and Biochemistry. 2024
Yukiko Ujie, Shun Saito, Keisuke Fukaya, Daisuke Urabe, Takashi Yaguchi, Midori A. Arai. Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound. Scientific Reports. 2024. 14. 1
Yuri Asano, Shun Saito, Yukiko Ujie, Chisato Iwata, Takashi Yaguchi, Midori A. Arai. Activation of Secondary Metabolism and Protease Activity Mechanisms in the Black Koji Mold Aspergillus luchuensis through Coculture with Animal Cells. ACS Omega. 2024. 9. 42. 43129-43137
Shun Saito, Midori A. Arai. Methodology for awakening the potential secondary metabolic capacity in actinomycetes. Beilstein Journal of Organic Chemistry. 2024. 20. 753-766
Shun Saito, Tomoya Banno, Midori A Arai. 3-Hydroxy-3-(2-oxopropyl)indolin-2-one, a product of a human-derived Enterocloster strain, is an inhibitor of nitric oxide production. Biosci Biotechnol Biochem. 2023

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MISC (132)：

鈴木しいな, 齋藤駿, 蒔田吉功, 新家一男, 荒井緑. Notchシグナル不活性型がんを標的とした微生物由来治療薬シードの探索. 日本生薬学会年会講演要旨集. 2022. 68回. 216-216
遠周直人, 林愛菜, 齋藤駿, 荒井緑. E3ユビキチンリガーゼプレートを用いた天然物由来tau分解分子糊の探索. 日本生薬学会年会講演要旨集. 2022. 68回. 197-197
成島悠貴, 林奈留美, 蒔田吉功, 石橋正己, 荒井緑. 高活性Notchシグナル阻害剤を目指したaciculatin誘導体の創製. 日本薬学会年会要旨集. 2022. 142年会. 27PO5-pm2
坂野智也, 齋藤駿, 荒井緑. 腸内細菌が生産する代謝物からの免疫機能制御物質の探索. 日本薬学会年会要旨集. 2022. 142年会. 27PO7-pm1
氏江優希子, 齋藤駿, 矢口貴志, 荒井緑. 病原真菌と免疫細胞の共培養法を用いた休眠遺伝子活性化による新規天然物の探索. 日本薬学会年会要旨集. 2022. 142年会. 27PO1-am2

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Patents (11)：

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Books (2)：

Development of the first spiro bis (isoxazoline) ligands (SPRIXs)
My Favorite Organic Synthesis The Society of Synthetic Organic Chemistry, Japan Ed. 2002
Development of the first spiro bis (isoxazoline) ligands (SPRIXs)
My Favorite Organic Synthesis The Society of Synthetic Organic Chemistry, Japan Ed. 2002

Works (4)：

前立腺癌をターゲットとしたビタミンD誘導体抗ガン剤の開発
2004 -
核内情報伝達を制御する分子の創製と新規解析システムによる機能解析
2004 -
Design and synthesis of vitamin D3 analogues as drugs for prostate cancer
2004 -
Development of high-thoroughput analyzing system of vitamin D3 analogues
2004 -

Education (7)：

1997 - 2000 The University of Tokyo
1997 - 2000 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
1995 - 1997 The University of Tokyo 大学院薬学研究科
1995 - 1997 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
1991 - 1995 The University of Tokyo Faculty of Pharmaceutical Sciences

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Professional career (1)：

Work history (24)：

2020/04 - 現在慶應義塾大学理工学部教授
2020/04 - 現在慶應義塾大学理工学部生命情報学科教授
2018/04 - 2019/03 Shizuoka University Lecturer (part-time)
2018/04 - 2019/03 Kyusyu University Lecturer (part-time)
2008/04 - 2019/03 Graduate School of Pharmaceutical Sciences, Chiba University Associate Professor

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Committee career (14)：

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Awards (9)：

2022 - 日本農芸化学会第19回農芸化学研究企画賞
2020/04 - 公益財団法人長瀬科学技術振興財団長瀬研究振興賞
2019 - The Pharmaceutical Society of Japan Award for Divisional Scientific Promotion
2014 - The SJWS (Society of Japanese Women Scientists) Promoting Scientific Award
2012 - Asian Core Program (Cutting-Edge Organic Chemistry in Asia) Lectureship Award

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Association Membership(s) (6)：

日本農芸化学会 , 日本化学会 , 有機合成化学協会 , 日本薬学会 , アメリカ化学会 , 日本ケミカルバイオロジー学会

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