Kitabayashi Issay

キタバヤシイッセイ | Kitabayashi Issay

Affiliation and department：
Job title： Deputy Director/Chief
Homepage URL (1)： http://www.ncc.go.jp/jp/nccri/divisions/12moon/12moon.html

Research field (3)： Tumor biology , Hematology and oncology , Molecular biology

Research keywords (10)：エピジェネティクス , ヒストン修飾 , 染色体転座 , 細胞分化 , 幹細胞 , 白血病 , Histone acetylation , chromosome translocation , cell differentiation , leukemia

Research theme for competitive and other funds (23)：

2014 - 2016 The mechanisms of immune-mediated tumor progression triggered by cancer metabolism
2010 - 2012 Proteomic analysis of phosphorylation in leukemic cells
2010 - 2012 Development of the novel AML treatments by targeting leukemia stem cells
2010 - 2012 Molecular mechanism for self-renewal of cancer stem cells
2010 - 2012 Development of Novel Treatment Strategies Targeting Cancer Stem Cells

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Papers (97)：

Ayuna Hattori, Emi Takamatsu-Ichihara, Yoshiki Yamamoto, Shuhei Fujita, Kazutsune Yamagata, Takuo Katsumoto, Yukino Machida, Haruka Shinohara, Ryo Murakami, Issay Kitabayashi. Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia. Leukemia. 2023
Haruka Shinohara, Rie Sawado, Makoto Nakagawa, Ayuna Hattori, Kazutsune Yamagata, Kimiharu Tauchi, Jumpei Ito, Yasumichi Kuwahara, Tsukasa Okuda, Chitose Ogawa, et al. Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors. Molecular therapy oncolytics. 2022. 27. 14-25
Jumpei Ito, Kazutsune Yamagata, Haruka Shinohara, Yutaka Shima, Takuo Katsumoto, Yukiko Aikawa, Issay Kitabayashi. Dual inhibition of EZH1/2 induces cell cycle arrest of B cell acute lymphoblastic leukemia cells through upregulation of CDKN1C and TP53INP1. International Journal of Hematology. 2022. 117. 1. 78-89
Takuo Katsumoto, Yoko Ogawara, Kazutsune Yamagata, Yukiko Aikawa, Ryo Goitsuka, Takuro Nakamura, Issay Kitabayashi. MOZ is critical for the development of MOZ/MLL-fusion-induced leukemia through regulation of Hoxa9/Meis1 expression. Blood Advances. 2022
Makoto Nakagawa, Masayuki Yamaguchi, Makoto Endo, Yukino Machida, Ayuna Hattori, Fumie Tanzawa, Shinji Tsutsumi, Issay Kitabayashi, Akira Kawai, Fumihiko Nakatani. Clinical usefulness of 2-hydroxyglutarate as a biomarker in IDH-mutant chondrosarcoma. Journal of Bone Oncology. 2022. 34. 100430-100430

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MISC (137)：

Issay Kitabayashi, Yukiko Aikawa, Kazutsune Yamagata, Takuo Katsumoto, Yutaka Shima, Akihiko Yokoyama, Yukino Machida, Haruka Shinohara, Yoko Ogawara, Shuhei Fujita, et al. Targeting driver mutations and critical factors in hematological and solid cancers. CANCER SCIENCE. 2022. 113. 1256-1256
北林一生, 相川祐規子, 山形和恒, 勝本拓夫, 島豊, 横山明彦, 町田雪乃, 篠原悠, 小川原陽子, 藤田修平, et al. ドライバー変異と必須因子を標的とした分子標的治療法の開発を目指して. 日本癌学会学術総会抄録集(Web). 2021. 80th
中川亮, 北林一生. 造血器腫瘍におけるEZH1/2を標的とした新規治療. 腫瘍内科. 2019. 24. 6. 704-710
OGOH Honami, YAMAGATA Kazutsune, NAKAO Tomomi, SANDELL Lisa L., YAMAMOTO Ayaka, YAMASHITA Aiko, TANGA Naomi, SUZUKI Mai, ABE Takaya, KITABAYASHI Issay, et al. Deregulation of histone methylation is implicated in the etiology of frontonasal dysplasia. 日本先天異常学会学術集会プログラム・抄録集. 2019. 59th
Kazutsune Yamagata, Mariko Saito, Mai Suzuki, Takuo Katsumoto, Honami Ogoh, Toshio Watanabe, Issay Kitabayashi. AF10 links histone chaperones Supt6h and FACT complex to MLL-fusion leukemia. CANCER SCIENCE. 2018. 109. 1111-1111

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Patents (3)：

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (2)：

2010/04 - 現在 National Cancer Center Research Institute Division of Hematological Malignancy Vice Director/Chief
2002/10 - 2010/03 National Cancer Center Research Institute Molecular Oncology Division Chief

Committee career (1)：

日本癌学会評議委員

Awards (2)：

2002 - 日本癌学会奨励賞
Japanese Cancer Association JCA-Mauvernay Award Molecular study of acute myeloid leukemia and its application for therapy

Association Membership(s) (8)：

米国血液学会 , 日本血液学会 , 日本分子生物学会 , 日本癌学会 , The Japanese Society of Hematology , The American Society of Hematology , The Molecular Biology Society of Japan , The Japanese Cancer Association

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