Art

J-GLOBAL ID：202002262715204416   Reference number：20A0180976

造血器腫瘍におけるEZH1/2を標的とした新規治療

Author (4)： NAKAGAWA MAKOTO (国立がん研究セ 中央病院 骨軟部腫瘍・リハビリテーション科) ,  NAKAGAWA MAKOTO (国立がん研究セ 研) ,  NAKAGAWA MAKOTO (九大 医 整形外科) ,  KITABAYASHI ISSEI (国立がん研究セ 研)
Material： 月刊腫瘍内科  (腫瘍内科)
Volume： 24  Issue： 6  Page： 704-710  Publication year： Dec. 28, 2019 
JST Material Number： L6395A  ISSN： 1881-6568  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *antitumor drug ,...
Semi thesaurus term： non-histone protein ,...

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JST classification (3)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Blood cell tumors(=neoplasms)  (GK04000M) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (5)： DS-3201b ,  CPI-1205 ,  GSK-126 ,  UNC-1999 ,  Tazemetostat

Reference (45)：

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• Cao R, Wang L, Wang H, et al. Role of Histone H3 Lysine 27 Methylation in Polycomb-group silencing. Science 2002 ; 298 : 1039.
• Czermin B, Melfi R, McCabe D, et al. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 2002 ; 111 : 185.
• Margueron R, Justin N, Ohno K, et al. Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 2009 ; 461 : 762.
• Cao R, Zhang Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell 2004 ; 15 : 57.

Terms in the title (4)： 造血器腫瘍 ,  EZH1 ,  標的 ,  治療