Rchr
J-GLOBAL ID：200901046196697002
Update date: Oct. 22, 2024
Akutsu Hideo
アクツ ヒデオ | Akutsu Hideo
Affiliation and department：
Job title：
Osaka University
Other affiliations (1)：
Research field (2)：
Biophysics
, Structural biochemistry
Research keywords (3)：
核磁気共鳴タンパク質の構造決定
, 生体エネルギー変換系生体情報変換の構造と機能
, Bioenergy-conversion system Structures and functions on clear Magnetic Resonance Structural determination of proteins Signal tram dnction
Research theme for competitive and other funds (32)：
- 2009 - 2014 Integrative understanding of biological processes mediated by transient macromolecul ar complexes; New technology for visualizing physiologically metastable states
- 2003 - 2009 Molecular soft interactions regulating membrane-interface activities in living systems
- 2003 - 2008 Intermolecular soft interactions regulating H^+-ATPsynthase function
- 2002 - 2004 Rotary catalysis mechanism of H^+-ATP synthase investigated by novel NMR methodology
- 1998 - 2001 Protein-protein interaction in intracellular signal transduction
- 1998 - 2001 Development of New Methodologies for Protein-Interaction Analysis
- 1998 - 1999 Structure and functions of a very small tetraheme protein -Molecular mechanism of bioremediation-
- 1997 - 1999 Development of Solid-State NMR Method for Studying Higher-Order Structure of Proteins
- 1997 - 1999 Structure-Function Analysis of HィイD1+ィエD1-ATP Synthase by Solution and Solid State NMR
- 1995 - 1999 Administration of researches on principles of protein architecture
- 1998 - 1998 NMRによるヒトリゾチームの変性構造解析
- 1997 - 1997 構造生物学にもとづくシグナル伝達機構の解明
- 1997 - 1997 NMRによるリゾチーム非天然構造の比較
- 1997 - 1997 チトクロムc_3におけるヘム・タンパク質相互作用と電子移動制御
- 1993 - 1996 Development of the stable isotope aided multidimensional NMR for the structure determination of nucleic acids
- 1993 - 1994 High-Resolution Solid-State NMR-A Novel Aspect of Structural Biology
- 1993 - 1993 金属蛋白質の多元的構造と反応過程制御
- 1992 - 1992 新局面を迎えたタンパク質の構造、物性、機能研究に関する我国の現状分析と展望
- 1991 - 1992 DEVELOPMENT OF A BIOSUPRAMOLECULAR NMR SYSTEM WITH A SUPERCONDUCTING MAGNET
- 1991 - 1992 Foundamental Studies on Bioelectric Devices
- 1991 - 1991 タンパク質立体構造の構築原理を解明するための基礎研究
- 1991 - 1991 金属蛋白質の多元的構造と反応過程制御
- 1990 - 1991 Quantum Theory and Spectroscopy of Proteins as Biomachines
- 1989 - 1991 Interheme Electron Transfer in cytochrome C_3 and The Role of Aromatic Amino Acids.
- 1986 - 1987 Strcture Formation of Biological Membranes
- 1985 - 1986 Investigation on the dynamic structure of the lipid-containing virus PM2 and correlation with the infectivity.
- 生体分子の固体NMRにおける構造解析
- H+-ATP合成酵素の構造と機能
- 電子伝達タンパク質における電子移動機構
- Structural analysis of biomolecules by solid-state NMR
- Structure and function of H+-ATPase
- Electron transfer mechanism in the electron transport proteins
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Papers (273)：
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Yasuto Todokoro, Yoshiyuki Miyasaka, Hiromasa Yagi, Masatsune Kainosho, Toshimichi Fujiwara, Hideo Akutsu. Structural analysis of ATP bound to the F1-ATPase β-subunit monomer by solid-state NMR- insight into the hydrolysis mechanism in F1. Biophysical chemistry. 2024. 309. 107232-107232
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Tsuyoshi Konuma, Tomoyo Takai, Chieko Tsuchiya, Masayuki Nishida, Miyu Hashiba, Yudai Yamada, Haruka Shirai, Aritaka Nagadoi, Eriko Chikaishi, Ken-ichi Akagi, et al. NMR analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria. 2023
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Yasuto Todokoro, Su-Jin Kang, Toshiharu Suzuki, Takahisa Ikegami, Masatsune Kainosho, Masasuke Yoshida, Toshimichi Fujiwara, Hideo Akutsu. Chemical Conformation of the Essential Glutamate Site of the c-Ring within Thermophilic Bacillus FoF1-ATP Synthase Determined by Solid-State NMR Based on its Isolated c-Ring Structure. Journal of the American Chemical Society. 2022. 144. 31. 14132-14139
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H. Akutsu. Structure and dynamics of phospholipids in membranes elucidated by combined use of NMR and vibrational spectroscopies. 2020. 1862. 9. 183352
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Tanaka, Hiroki, Akutsu, Hideo, Yabuta, Izumi, Hara, Masashi, Sugimoto, Hayuki, Ikegami, Takahisa, Watanabe, Takeshi, Fujiwara, Toshimichi. A novel chitin-binding mode of the chitin-binding domain of chitinase A1 from Bacillus circulans WL-12 revealed by solid-state NMR. FEBS LETTERS. 2018. 592. 18. 3173-3182
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MISC (102)：
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AKUTSU Hideo, AKUTSU Hideo, TODOKORO Yasuto, KANG Su-Jin, SUZUKI Toshiharu, IKEGAMI Takahisa, KAINOSHO Masatune, YOSHIDA Masasuke, FUJIWARA Toshimichi. Thermodynamic mechanism underlying the rotation of the c-subunit rotor of F0F1-ATP synthase. 生物物理(Web). 2023. 63. Supplement 1-2
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戸所泰人, KANG Su-jin, KANG Su-jin, 鈴木俊治, 吉田賢右, 池上貴久, 藤原敏道, 阿久津秀雄, 阿久津秀雄. 好熱菌H+-ATP合成酵素サブユニットcリングの膜内構造の精密化. Abstracts. Annual Meeting of the NMR Society of Japan. 2019. 58th (CD-ROM)
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阿久津秀雄, 阿久津秀雄, 阿久津秀雄, KANG Su-Jin, 戸所泰人, 鈴木俊治, 吉田賢右, 藤原敏道. 好熱菌F型ATP合成酵素c-リングの固体NMRによる研究. 日本生体エネルギー研究会討論会講演要旨集. 2017. 43rd
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戸所泰人, 戸所泰人, KANG Su-jin, 湯面郁子, 岩崎郁, 鈴木俊治, 吉田賢右, 鈴木俊治, 吉田賢右, 藤原敏道, et al. 脂質二重膜再構成H+-ATP合成酵素subunit c-ringの固体高分解能NMR法による構造決定. Abstracts. Annual Meeting of the NMR Society of Japan. 2013. 52nd
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Kang Su-Jin, Todokoro Yasuto, Yumen Ikuko, Shen Bo, Iwasaki Iku, Suzuki Toshiharu, Miyagi Atsushi, Yoshida Masasuke, Fujiwara Toshimichi, Akutsu Hideo. 3P100 The Active-Site Structure of Thermophilic F_oF_1-ATP Synthase c-Subunit Rings in Membranes(03. Membrane proteins,Poster). Seibutsu Butsuri. 2013. 53. 1. S228
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Books (2)：
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Structure-activity relationships for mini-atrial natriametic peptide by proliue-scauuing mutagenesis and shonteuing of peptide backboue
Bioorg,Med,cgeu Lett 2002
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Structure-activity relationships for mini-atrial natriuretic peptide by proline-scanning mutagenesis and shonrening of peptide backbone
Bioorg. Med. Chem. Lett. 2001
Works (6)：
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固体高分解能NMRによる生体高分子相互作用解析技術の開発
2005 -
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ゲノム蛋白質の高効率・高精度NMR解析法の開発
2005 -
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生命秩序の膜インターフェイスを制御するソフトな分子間相互作用
2005 -
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生命秩序の膜インターフェイスを制御するソフトな分子間相互作用
2004 -
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H+-ATP合成酵素等の機能制御におけるソフトな分子間相互作用
2004 -
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Education (3)：
- 1973 - The University of Tokyo Doctor of Science
- 1967 - 1972 The University of Tokyo
- 1963 - 1967 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
Professional career (2)：
- Doctor of Science (The University of Tokyo)
- Master of Science (The University of Tokyo)
Work history (9)：
- 2007/04 - 現在 Osaka University Institute for Protein Research Professor Emeritus
- 2006/11 - 現在 Yokohama City University Graduate School of Medical Life Science Guest Professor
- 2014/05 - 2016/04 Japan Society for the Promotion of Science Stockholm Office Director
- 2007/04 - 2014/03 Osaka University Institute for Protein Research Guest Professor
- 2009/09 - 2013/08 Seoul National University Department of Biophysics and Chemical Biology WCU Professor
- 2000/04 - 2007/03 Osaka University Institute for Protein Research Professor
- 1991/10 - 2001/03 Yokohama National University Faculty of Engineering Professor
- 1985/10 - 1991/09 Yokohama National University Faculty of Engineering Associate Professor
- 1972/04 - 1985/09 Osaka University Institute for Protein Research Assistant Professor
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Committee career (6)：
Awards (1)：
Association Membership(s) (8)：
Protein Society
, Biophysical Society
, Society of Biological Inorganic Chemistry
, 日本核磁気共鳴学会
, 日本蛋白質科学会
, 日本生化学会
, 日本生物物理学会
, 日本化学会
