Umezu Mitsuo | Researcher Information

2018 - 2021 Development of the small blood circulation simulator to deepen the non-clinical evaluation of medical devices
2017 - 2021 Safety and Effectiveness of Stentless Mitral Valve for Mitral Stenosis
2017 - 2020 Construction of ventricular tissue from human iPS cell-derived cardiomyocytes on vECM-nanographene composite substrate
2015 - 2018 Development of mock circulation systems for the evaluation of innovative medical devices
2015 - 2018 Elucidation of blood flow control mechanisms for establishing a wide area of simulator of brain circulation after cerebral revascularization

2014 - 2017 Development of a tissue with in vivo regeneration capability for reconstruction of anterior cruciate ligament using decellularization and tissue-sterilization technologies

2015 - 2017 新規治療機器を実臨床に導入時に有効な循環シミュレータの開発

2013 - 2016 Cardiac tissue engineering through the creation of a novel culture substrate promoting cardiomyocytes differentiation and selection

2013 - 2015 Study on how to apply a simulation technique to evaluate a development of new medical devices and a possibility of their market approval

2012 - 2015 Development of a supporting technology for bypass surgery for complex intracranial aneurysms using a blood flow simulator

2011 - 2014 Clinical Application of Echocardiographic Blood Flow Visualization System

2011 - 2014 Establishment of a simulation method to evaluate a software of blood flow distribution in artificial grafts

2011 - 2014 Preoperative simulation of pediatric cardiac surgery analyzed by computational fluid dynamic study

2011 - 2014 Developement of a new stentless mitral valve for clinical application

2012 - 2013 抗血栓性評価の新展開

2012 - 2013 自己治癒能力を引き出す無細胞化組織実用化のための総合的基礎研究

2011 - 2013 Development of an artificial papillary muscle recovering left ventricular functions

2010 - 2013 Cerebral aneurysm rupture risk estimation of with artery thickness.

2010 - 2013 Enhancement of the Differentiation of Cardiomyocytes from Mouse Embryonic Stem Cells and Creation of Ventricular Model based on modification of scaffold

2009 - 2011 An innovative treatment approach supporting development of surgeons' imaging by the TAAA Navigator

2005 - 2009 Development of a passive-active artificialmyocardium reconcilingthe physiological demands with hemodynamic changes

2006 - 2008 Development of newly designed pressure sensor for regenerative medicine and artificial organs

2006 - 2008 The research and development of durable decellularized aortic valves in collaboration with engineers.

2004 - 2007 Construction of engineered cardiac tissue possessing the contractile characteristics of in vivo myocardium

2005 - 2006 Flow field analysis of the flow around and inside the valsalva and of the coronary flow influenced by the prosthetic aortic valve

2003 - 2005 Development of evaluation system for artificial organs from the viewpoints of clinical study, engineering, and statistics.

2002 - 2005 Establishment of support technology for the development of surgical training simulator

2001 - 2005 生命科学・医工学統合研究に基づく未来医療への挑戦的研究

2002 - 2004 1ヶ月保証の超低価格血液ポンプの実用化を阻む要素の徹低解明

2000 - 2004 生物学をベースとした骨格系運動生理モデルの構築と医療応用

2001 - 2003 Investigation of Usefulness of "Recovery-Directed Left Ventricular Assist Device" invented based on a new concept

2000 - 2003 Develop of High Performance Stents

2000 - 2002 Experimental Comparison of End-to-Side and Side-to-Side Anastomosis for Coronary Artery Bypass Grafting

2000 - 2001 Establishment of production process of cellular- type oxygen carriers

2000 - 2000 体育学分野におけるセンシング技術の現状調査と将来予測

1999 - 2000 新鮮な血液を用いた機械加工表面性状の定量評価の試み

1996 - 2000 人工臓器素材開発

1999 - 1999 体力・健康度に対する定量的評価の確立に向けての調査研究

1999 - 1999 生体模倣部品開発プロジェクト

1998 - 1999 Analysis of flow behavior of blood-biomaterial interfaces

1997 - 1999 Prediction of durability of artificial organs using an accerelated fatigue tester

1997 - 1999 Development of a mock circulatory system as a supporting tool to propose the oprimal cardiac surgery

1995 - 1996 Development of viscoelastic tubes similar to blood pump

1994 - 1996 Development of spiral-vortex-type blood pump (Optimal design and its application to cardiomyoplasty)

1994 - 1996 Development of a Internationally acceptable fatigue test system for prosthetic heart valve

1995 - 1995 循環系および運動系の力学的解析に基づくウェイトリフティングの最適訓練法の提唱

1991 - 1993 Developed of spiral vortex-type artificial heart

1986 - 1988 Development of a permanent use completely implantable total artificial heart system

1986 - 1988 全人工心臓(TAH)置換動物における循環維持と制御に関する研究

1986 - 1987 Experimental and clinical studies of ventricular assist system for acute profound heart failure.

1984 - 1986 Development and evaluation of motor-driven, pusher-plate-type artificial heart system

臨床に直接貢献できる実用型小児先天性心疾患の血流シミュレーションシステムの構築

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松橋祐輝, 岩崎清隆, 高橋東, 平田麻由紀, 梅津光生. 異なる機械式弁を組み込んだ拍動型補助人工心臓のin-vitro溶血性能比較評価,. 第42回人工心臓と補助循環懇話会学術集会プログラム・抄録集. 2114. 137
Shida, Takuya, Umezu, Mitsuo, Umezu, Mitsuo, Iwasaki, Kiyotaka, Iwasaki, Kiyotaka. Investigation of adverse events associated with an off-label use of arterial stents and CE-marked iliac vein stents in the iliac vein: insights into developing a better iliac vein stent. Journal of Artificial Organs. 2018. 1-7
Yuki Matsuhashi, Kei Sameshima, Yoshiki Yamamoto, Mitsuo Umezu, Kiyotaka Iwasaki. Real-time visualization of thrombus formation at the interface between connectors and tubes in medical devices by using optical coherence tomography. PLOS ONE. 2017. 12. 12
Yuki Matsuhashi, Kei Sameshima, Yoshiki Yamamoto, Mitsuo Umezu, Kiyotaka Iwasaki. Investigation of the influence of fluid dynamics on thrombus growth at the interface between a connector and tube. JOURNAL OF ARTIFICIAL ORGANS. 2017. 20. 4. 293-302
Azuma Takahashi, Sara Suzuki, Yusuke Aoyama, Mitsuo Umezu, Kiyotaka Iwasaki. A three-dimensional strain measurement method in elastic transparent materials using tomographic particle image velocimetry. PLOS ONE. 2017. 12. 9

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生体組織の処理方法及び生体組織
血液適合性等の評価用の実験方法
保存処理時の生体組織の保持方法及び保持具、並びに保存処理された生体組織
ステントレス人工僧帽弁及び人工弁葉
無細胞化方法及び人体移植用人工組織

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人工臓器で幸せですか?
コロナ社 2005

Our trial on biomedical engineering research and education system related to medical regulatory science,
(7th WACBE World Congress on Bioengineering 2015)
My 40 years journey for a development of artificial hearts and clinical application,
(ASCC 2015 10th Asian Control Conference 2015)
CFDが開く血流解析の新時代第,
(30回日本脳神経血管内治療学会ランチョンセミナー講演 2015)
東京女子医科大学・早稲田大学連携先端生命医科学研究施設(TWIns)の取り組みについて
(医工連携シンポジウムinあきた2015, 2015)
循環器系DRYラボセンターを駆使した治療リスクの低減システム構築と人材育成,
(平成26年度厚生労働科学研究事業研究成果発表会, 2015)

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工学博士 (早稲田大学)
Doctor of Engineering (Waseda Unversity)
Doctor of Medical Science (Tokyo Women's Medical University)

2012/03 - 2011 JBSE GRAPHICS OF THE YEAR AWARD
2010/11 - Excellent poster award(ISOMRM ,Taiwan)
2010/09 - 日本バーチャルリアリティ学会論文賞
2009/09 - Young Investigator Award 1st Praze:11th international congress of the IUPESM,T Yagi, S Wakasa, N Tokunaga, Y Akimoto, M Umezu
2008/12 - Outstanding paper award: The 13th International Conference Biomedical Engineering, K Iwasaki, S Tsubouchi, Y Hama, m Umezu: Successful reproduction of In-Vitro fracture of an endovascular stent in superficial femoral artery utilizing a novel multi-loading

2008/12 - Outstanding paper award:K Sakaguchi, T shimizu, k Iwasaki, m yamato, M Umezu, T Okano: Fabrication of three dimensional tissues with perfused microchannels, The 13th International Conference Biomedical Engineering, The 13th International Conference Biomed

2008/12 - Outstanding paper award: The 13th International Conference Biomedical Engineering, K Iwasaki, S Tsubouchi, Y Hama, m Umezu: Successful reproduction of In-Vitro fracture of an endovascular stent in superficial femoral artery utilizing a novel multi-loading durability test system, The 13th International Conference Biomedical Engineering, 2008.12,(Singapore)

2008/12 - Outstanding paper award:K Sakaguchi, T shimizu, k Iwasaki, m yamato, M Umezu, T Okano: Fabrication of three dimensional tissues with perfused microchannels, The 13th International Conference Biomedical Engineering, The 13th International Conference Biomedical Engineering program and abstracts, Biomedical Engineering Society Singapore, pp192, 2008.12,(Singapore

2008/11 - Best Poster Award gold prize田中智美、山家弘雄、岡本吉弘、小橋宏行、岩崎清隆、梅津光生、寺田友昭、板倉徹第24回日本脳神経血管内治療学会総会、プログラム抄録vol.2,no.4、pp262、Journal of Neuroendovascular Therapy、2008.11(ポスター発表)

2008 - Best Poster Award bronze prize北谷優太郎、高尾洋之、銭逸、福井弘一、石橋敏寛、村山雄一、梅津光生:血流シミュレーション技術を用いた破裂脳動脈瘤の形状的要素の検討、第24回日本脳神経血管内治療学会総会、第24回日本脳神経血管内治療学会総会プログラム抄録vol.2,no.4、pp295、Journal of Neuroendovascular Therapy、2008.11(ポスター発表)

2007/11 - 日本脳神経血管内治療学会ポスター銀賞:田中智美、山家弘雄、岡本吉弘、矢田裕紀、小橋宏行、岩﨑清隆、梅津光生、寺田友昭、板倉徹

2007/07 - Excellent cooperation on Educational Invited Lecture 2,第12回日本冠動脈外科学会,2007.7Mitsuo Umezu:JACAS2007,

2006/09 - “Young Scientist Award”12th International Symposium on Flow Visualization,Germany,T Yagi,D Ishikawa,H Sudo,T Akutsu,W Yang,K Iwasaki,M Umezu,Real- Time planar spectral analysis of instantaneous high-frequency stress on blood cells downstream of an artific

2006/09 - “Young Scientist Award”12th International Symposium on Flow Visualization,Germany,T Yagi,D Ishikawa,H Sudo,T Akutsu,W Yang,K Iwasaki,M Umezu,Real- Time planar spectral analysis of instantaneous high-frequency stress on blood cells downstream of an artificial heart valve,

2005/12 - Outstanding Paper Award,K Iwasaki,S Ozaki,T Kawai,S Yamaguchi,M Eto,Y Ohba,Y Ohzeki,M Umezu,12th International Conference on Biomedical Engineering

2005/11 - Technical Award (Japanese Society for Artificial Organs,2005)

2005/09 - 生体医工学シンポジウムベストリサーチアワード,植松美幸,白石泰之,関根一光,山家智之,西條芳文,安藤隼人,朴栄光,武田朴,岩﨑清隆,梅津光生:左心室形成術における切除線決定のための診断法の開発,2005,9月

2001 - Hpnorable Award

1999 - 人工臓器貢献賞(チェコ)

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ライフサポート学会 , 日本機械学会 , Japanese Society for Artificial Organs , International Society for Artificial Organs