Rchr
J-GLOBAL ID:200901049672847980   Update date: May. 25, 2020

Kataoka Tohru

カタオカ トオル | Kataoka Tohru
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://www.med.kobe-u.ac.jp/molbiol/top.htm
Research field  (2): Pathobiochemistry ,  Medical biochemistry
Research keywords  (5): inositol lipid signaling ,  ras oncogene ,  small G protein ,  intracellular signal transduction ,  mechanism of carcinogenesis
Papers (66):
  • UMEZAWA KANOKO, NAGANO TATSUYA, KOBAYASHI KAZUYUKI, DOKUNI RYOTA, KATSURADA MASAHIRO, YAMAMOTO MASATSUGU, YOSHIKAWA YOKO, KATAOKA TOHRU, NISHIMURA YOSHIHIRO. Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells. Respiratory Research. 2019. 20. 9. 1-12
  • Matsumoto S, Hiraga T, Hayashi Y, Yoshikawa Yoko, Tsuda C, Araki M, Neya M, SHIMA FUMI, Kataoka Tohru. Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring. Biochemistry. 2018. 57. 36. 5350-5358
  • MAETA KAZUHIRO, HATTORI SATOKO, IKUTOMO JUNJI, EDAMATSU HIRONORI, BILASY SHYMAA E, MIYAKAWA TSUYOSHI, KATAOKA TOHRU. Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain. Molecular Brain. 2018. 11. 27. 1-22
  • Yoko Yoshikawa, Osamu Takano, Ichiro Kato, Yoshihisa Takahashi, Fumi Shima, Tohru Kataoka. Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1 alpha pathway. CANCER LETTERS. 2017. 410. 82-91
  • FaragMI, Yoshikawa Yoko, MaetaK, Kataoka Tohru. Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression. Biochem Biophys Res Commun. 2017. 493. 1. 139-145
more...
MISC (8):
  • Shima Fumi, MatsumotoS, Yoshikawa Yoko, Kawamura Takashi, Isa Masayuki, Kataoka Tohru. Current status of the development of Ras inhibitors. J Biochem. 2015. 158. 2. 91-9
  • 島 扶美, 吉川 陽子, 松本 篤幸, Kataoka Tohru. rasがん遺伝子産物Rasを分子標的としたがん治療薬開発の現状. がん分子標的治療. 2015. 13. 1. 92-98
  • Shima Fumi, 熊坂崇, Matsumoto Shigeyuki, Yoshikawa Yoko, 山本雅貴, Kataoka Tohru. rasがん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発. 日本放射光学会誌 放射光. 2014. 27. 1. 3-9
  • Edamatsu Hironori, Kataoka Tohru. Phospholipase Cε as a potential molecular target for anti-inflammatory therapy and cancer prevention. Inflammation and regeneration. 2011. Vol. 31, No. 4, pp. 370-374
  • Kataoka Tohru. Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB reports. 2008. Vol. 41, No. 6, pp. 415-34
more...
Patents (2):
  • Ras機能阻害作用を有するチオキソチアゾリジン誘導体
  • Ras機能阻害作用を有するチオキソチアゾリジン誘導体(アメリカ)
Books (4):
  • ras がん遺伝子産物 Ras を分子標的としたがん治療薬開発の現状
    がん分子標的治療 2015
  • SPring-8 Research Frontiers 2013 / Structure-based drug design of small-molecule Ras inhibitors having anti-tumor activity
    Japan Synchrotron Radiation Institute 2014
  • The Enzymes, Vol. 34, Inhibitors of the Ras superfamily G-proteins, Part B / Discovery of Small-Molecule Ras Inhibitors that Display Antitumor Activity by Interfering with Ras・GTP?Effector Interaction
    Elsevier Inc. 2013
  • 次世代がん戦略研究Update がん基盤生物学 革新的シーズ育成に向けて / がん微小環境を制御するRas/Rap標的タンパク質PLCεの選択的阻害剤の開発
    南山堂 2013
Lectures and oral presentations  (168):
  • Development of anti-cancer drugs targeting the ras oncogne products
    (理研シンポジウム「第4回DMP(創薬・医療技術基盤プログラム)創薬ワークショップ」 2018)
  • Conformational changes on GTP hydrolysis of oncogene product Ras as revealed by monitoring of time-dependent NMR signal using caged-GTP
    (The 56th Annual Meeting of The Biophysical Society of Japan 2018)
  • Specific inhibitors of phospholipase Cepsilon (PLCepsilon) display anti-tumor and cancer-preventive effects as well as anti-inflammatory effect.
    (IUBMB Seoul 2018 2018)
  • ブレオマイシン誘導肺線維症マウスモデルにおけるPLCεの役割
    (第58回日本呼吸器学会学術講演会 2018)
  • Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε(ポスター発表)
    (2018 Keystone Symposia Conference 2018)
more...
Awards (4):
  • 2009/11 - 兵庫県 兵庫県科学賞 ras癌遺伝子産物の機能の解明とそれを標的とした抗癌剤の開発研究を通じた医学の発展への貢献
  • 2007/10 - 財団法人井植記念会 第31回井植文化賞(科学技術部門) 兵庫県在住の個人・団体または特に兵庫県にゆかりの深い個人・団体。各分野で前年度、とくにめざましい活躍をし、かつ、多大な貢献をした個人・団体
  • 2007/10 - 井植記念会 井植文化賞 医学・分子生物学四分野での独創的かつ世界的な研究成果
  • 1981/03 - 日本分子生物学会 日本分子生物学会研究奨励賞(第1回) 免疫グロブリン遺伝子の構造変換と発現の機構に関する研究成果
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