2019 - 2022 Elucidation of cancer proliferation mechanisms based on signal transduction from organelles different from normal cells
2020 - 2022 非対称糖鎖構造を持つIgG 作製とその機能評価
2016 - 2019 Identification of intracellular activation sites of mutated tyrosine kinases in tumor cells and drug development based on the cellular localization
2016 - 2018 Basic research for development of the DDS system considering tissue and intracellular drug distribution
2015 - 2018 Elucidation of the chemoresistance in pancreatic cancer and development of its tumor stroma targeting ADCs
2015 - 2018 C-Mannosylation is involved in the regulation of epithelial-cell adhesion.
2015 - 2018 1,2-cis aminoglycoside synthesis by anomerization stragegy
2015 - 2017 Development of a novel antibody gene complex for the gene therapy of heart failure.
2012 - 2016 Synthesis of Biologically Active Oligosaccharide Using Anomerization Reaction via Endocyclic Cleavage Reaction
2010 - 2012 Analysis of the tumor biological factor regulating the antibody-delivery
2009 - 2011 The Unique Reactivity of Conformationally Restricted Pyranosides
2008 - 2010 Protein C-mannosylation and signaling related to innate immunity
2005 - 2009 Development of drug or gene delivery system for clinical application.
2004 - 2009 遺伝子およびドラッグデリパリーシステムのがん臨床応用をめざす研究
2007 - 2008 Origin of the high stereoselectivity of glycosyl donors
2004 - 2005 新規C-結合型糖鎖修飾ペプチドの合成と生物学的意義解明
2002 - 2005 糖鎖迅速合成と多様性指向型合成への挑戦
2001 - 2003 Organic Synthesis of Glycoprotein Structural Motifs
2001 - 2002 糖鎖固相合成反応のモニタリング法確立と新規リンカーの開発
1998 - 1999 固相における多成分カップリングによる高効率的糖鎖合成
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Papers (134):
Shotaro Tabata, Yusuke Yamashita, Yoko Inai, Shuhei Morita, Hideki Kosako, Tomoyuki Takagi, Kotaro Shide, Shino Manabe, Taka-Aki Matsuoka, Kazuya Shimoda, et al. C-Mannosyl tryptophan is a novel biomarker for thrombocytosis of myeloproliferative neoplasms. Scientific reports. 2024. 14. 1. 18858-18858
Shino Manabe, Shogo Iwamoto, Satoru Nagatoishi, Asako Hoshinoo, Ai Mitani, Wataru Sumiyoshi, Takashi Kinoshita, Yoshiki Yamaguchi, Kouhei Tsumoto. Systematic Preparation of a 66-IgG Library with Symmetric and Asymmetric Homogeneous Glycans and Their Functional Evaluation. Journal of the American Chemical Society. 2024
Methanee Hiranyakorn, Shogo Iwamoto, Asako Hoshinoo, Ryo Tsumura, Hiroki Takashima, Masahiro Yasunaga, Shino Manabe. Chromatographic Analysis of the N-Glycan Profile on Therapeutic Antibodies Using FcγRIIIa Affinity Column Chromatography. ACS Omega. 2023. 8. 18. 16513-16518
Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Yoshito Ihara. Functions of Protein C-Mannosylation in Physiology and Pathology. Trends in Glycoscience and Glycotechnology. 2023. 35. 204. E23-E27
Yahani P. Jayasinghe, Michael T. Banco, Jared J. Lindenberger, Lorenza Favrot, Zuzana Palčeková, Mary Jackson, Shino Manabe, Donald R. Ronning. The Mycobacterium tuberculosis mycothiol S-transferase is divalent metal-dependent for mycothiol binding and transfer. RSC Medicinal Chemistry. 2023. 14. 3. 491-500
日本抗体学会
, 日本分子イメージング学会
, 日本核医学会
, THE JAPANESE SOCIETY OF APPLIED GLYCOSCIENCE
, THE JAPANESE CANCER ASSOCIATION
, 日本薬学会
, 日本化学会
, 有機合成化学協会
, 日本農芸化学会
, 日本糖質学会
, アメリカ化学会
, 日本DDS 学会
, FCAA(Forum: Carbohydrate Coming of Age)
, 日本プロセス学会
, 日本ケミカルバイオロジー学会