Masatsugu Oh-hora

Affiliation and department：

Research field (2)： Medical biochemistry , Immunology

Research keywords (4)：シグナル伝達 , 自己免疫疾患 , カルシウム , T細胞分化

Research theme for competitive and other funds (9)：

2021 - 2025 Elucidation of molecular mechanisms of lymphopoiesis by essential minerals through TRPM7
2018 - 2021 Elucidation of novel molecular mechanisms of early T cell development by regulation of intracellular ion homeostasis
2017 - 2020 Molecular basis for the mechanism of ectodermal dysplasia caused by abnormal calcium signaling
2014 - 2017 Elucidation of molecular mechanisms of the selection and maturation of thymocytes
2014 - 2016 Calcium signal as a potential clinical target for breast cancer

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Papers (53)：

Kei Nagao, Soichiro Yoshikawa, Hitoshi Urakami, Yuki Fujita, Ayaka Komura, Miho Nakashima, Masatsugu Oh-Hora, Atsushi Fujimura, Takeshi Y Hiyama, Keiji Naruse, et al. Ligand-independent function of β2-adrenergic receptor affects IgE-mediated Ca2+ influx in mast cells. Biochemical and biophysical research communications. 2024. 733. 150595-150595
Airi Jo-Watanabe, Toshiki Inaba, Takahiro Osada, Ryota Hashimoto, Tomohiro Nishizawa, Toshiaki Okuno, Sayoko Ihara, Kazushige Touhara, Nobutaka Hattori, Masatsugu Oh-Hora, et al. Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury. Nature communications. 2024. 15. 1. 1530-1530
Hiroki Nakajima, Sayaka Fujita, Masashi Kakae, Kazuki Nagayasu, Masatsugu Oh-Hora, Hisashi Shirakawa, Shuji Kaneko. Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α-stimulated astrocytes. Glia. 2022. 70. 9. 1666-1680
Xiuyuan Lu, Masatsugu Oh-Hora, Kiyoshi Takeda, Sho Yamasaki. Selective suppression of IL-10 transcription by calcineurin in dendritic cells through inactivation of CREB. International immunology. 2022. 34. 4. 197-206
Oh-Hora M, Lu X, Shiokawa M, Takayanagi H, Yamasaki S. Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders. J Immunol. 2019. 202. 9. 2616-2627

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MISC (8)：

S. Yoshikawa, M. Oh-hora, T. Adachi, Y. Yamanishi, H. Karasuyama. Stromal interaction molecule-1/2 plays essential role in basophil activation and development of IgE-mediated chronic allergic inflammation. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 99-99
Masatsugu Oh-hora, Noriko Komatsu, Anjana Rao, Hiroshi Takayanagi. Mechanism of the development of autoimmune diseases by impaired store-operated calcium entry. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 67P-67P
Kwong Tai Cheng, Ilias Alevizos, Xibao Liu, Wiliam D. Swaim, Hongen Yin, Stefan Feske, Masatsugu Oh-hora, Indu S. Ambudkar. STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome (vol 109, pg 14544, 2012). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109. 45. 18625-18625
Kwong Tai Cheng, Ilias Alevizos, Xibao Liu, Wiliam D. Swaim, Hongen Yin, Stefan Feske, Masatsugu Oh-hora, Indu S. Ambudkar. STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome (vol 109, pg 14544, 2012). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109. 44. 18625-18625
Kazuo Okamoto, Masatsugu Oh-hora, Hiroshi Takayanagi. An essential role of I kappa B zeta in the transcriptional program in Th17 development. ARTHRITIS RESEARCH & THERAPY. 2012. 14

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Professional career (1)：

博士(医学) (大阪大学)

Committee career (1)：

- 現在日本免疫学会評議員

Awards (1)：

2010 - 日本免疫学会研究奨励賞

Association Membership(s) (5)：

日本生化学会 , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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