Rchr
J-GLOBAL ID：200901055110907181
Update date: Oct. 19, 2024
Sawa Tomohiro
サワ トモヒロ | Sawa Tomohiro
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://www.microbio-ku.jp
Research field (2)：
Medical biochemistry
, Pharmaceuticals - chemistry and drug development
Research keywords (5)：
薬剤耐性
, 抗生物質
, 酸化ストレス
, 活性イオウ分子
, 生体機能物質
Research theme for competitive and other funds (42)：
- 2023 - 2026 多面的癌制御でBNCTのさらなる治療効果向上を目指すホウ素ナノ粒子の研究
- 2021 - 2026 NADPH oxidase mediates supersulfide activation and regulates infection and inflammatory responses
- 2021 - 2026 Management of international relation and facility for promotion of research on sulfur biology
- 2022 - 2025 消化器癌の革新的治療法開発を目指したハダカデバネズミ腸内細菌のマルチオミクス解析
- 2022 - 2025 Innovative antibacterial drug delivery system to intracellular bacteria
- 2021 - 2024 Molecular mechanisms of inhibitory regulation of NLRP3 inflammasome by reactive sulfur species
- 2021 - 2023 多面的癌制御でBNCTの効果を飛躍的向上に導く薬剤の基礎的研究
- 2020 - 2023 Molecular mechanisms of glutathione transport-dependent regulation of NLRP3 inflammasome
- 2020 - 2023 革新的治療開発を目指した腸内細菌Fusobacteriumと腫瘍免疫の網羅的解析
- 2019 - 2021 Mechanisms of intracellular bacterial killing induced by reactive sulfur species
- 2018 - 2021 Molecular mechanisms of NLRP3 inflammasome activation via glutathione efflux
- 2017 - 2020 Comprehensive analysis of gut microbiome and epigenetic changes in esophageal cancer.
- 2017 - 2019 Comprehensive analysis of gut microbiome before and after gastroenterological surgery.
- 2017 - 2019 Reactive sulfur metabolomics for the study of cellular sulfur dynamics
- 2016 - 2019 Regulation of redox signaling by reactive sulfur species in nervous system
- 2014 - 2019 Polysulfur metabolome and regulation of anti-oxidative stress responses
- 2015 - 2018 The analysis of the mechanisms of HERV-K expression
- 2015 - 2018 Molecular mechanisms for metabolisms of bacterial reactive sulfur species: implication in antibacterial resistance
- 2014 - 2016 Regulatory mechanisms of protein S-polythiolation
- 2013 - 2016 Mechanism of intracellular formation of cysteine polysulfide and reactive oxygen species signaling
- 2012 - 2015 Regulatory mechanisms of redox signal transduction mediated by endogenous electrophiles
- 2008 - 2013 Molecular regulation of ROS signal receptor proteins: S-guanylation proteomics
- 2009 - 2011 Molecular mechanisms of oxidative stress regulation by nucleic acid nitration
- 2007 - 2008 Biological formation of 8-nitroguanosine 3'5'-cyclic monophosphate and its implication in NO signaling
- 2008 - 活性酸素、一酸化窒素のシグナル伝達機能
- 2008 - Signaling function of reactive oxygen species and nitric oxide
- 2005 - 2007 Molecular mechanisms of nitric oxide-dependent modification and regulation of genome functions
- 2007 - 炎症発がんのメカニズム
- 2003 - 2006 Molecular regulatory mechanisms of NO analyzed by using nitronyl nitroxide
- 2000 - 2002 Study on the mechanism of nitrosothiol formation in biological systems
- 2000 - 2002 Research on the role of NO in microbial pathogenesis
- 2000 - 2002 Research on microbial mutation and evolution involving oxidative stress
- 2001 - 2001 タンパク質・核酸の生体内ニトロ化反応メカニズムの解析
- 2000 - 2000 ポリマー結合酸化酵素による癌のターゲティング化学療法
- 2000 - 2000 固型腫瘍の発育・進展における一酸化窒素・酸素ラジカルの役割についての研究
- 2000 - 2000 慢性感染に伴うフリーラジカル産生と発がん
- 1999 - 2000 微生物感染・炎症における遺伝子損傷の分子メカニズム
- 1999 - 1999 Free radical generation in chronic infection and its implication in carcinogenesis
- 1997 - 1999 Therapeutic application of NO scavenger and NO donor for endotoxin shock
- 1997 - 1999 Matrix metalloproteinase activation in bacterial pathogenesis
- 1997 - 1999 Molecular Mechanisms of Redox-Regulation in Viral Pathogenesis
- 1998 - 1998 生体内ラジカル生成による発癌と抗ラジカル物質によるがん抑制
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Papers (149)：
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Yoshihiro Hara, Yoshifumi Baba, Eri Oda, Kazuto Harada, Kohei Yamashita, Tasuku Toihata, Keisuke Kosumi, Masaaki Iwatsuki, Yuji Miyamoto, Hiroyasu Tsutsuki, et al. Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers. British journal of cancer. 2024. 131. 5. 797-807
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Xiaoyan Li, Touya Toyomoto, Tianli Zhang, Chunyu Guo, Stephen Lindahl, Hiroyasu Tsutsuki, Ming Xian, Tomohiro Sawa. Supersulfides suppress type-I and type-II interferon responses by blocking JAK/STAT signaling in macrophages. International immunology. 2024
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Stephen Lindahl, Meg Shieh, Tianli Zhang, Chunyu Guo, Jerome R Robinson, Tomohiro Sawa, Ming Xian. Thioglucose-derived tetrasulfide, a unique polysulfide model compound. Redox biology. 2024. 70. 103045-103045
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Yosuke Maeda, Mako Toyoda, Takeo Kuwata, Hiromi Terasawa, Umiru Tokugawa, Kazuaki Monde, Tomohiro Sawa, Takamasa Ueno, Shuzo Matsushita. Differential Ability of Spike Protein of SARS-CoV-2 Variants to Downregulate ACE2. International journal of molecular sciences. 2024. 25. 2
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Mayumi Ikeda-Imafuku, Tatsuya Fukuta, Victor Tuan Giam Chuang, Tomohiro Sawa, Toru Maruyama, Masaki Otagiri, Tatsuhiro Ishida, Yu Ishima. Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways. Pharmaceuticals (Basel, Switzerland). 2024. 17. 1
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MISC (379)：
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松永哲郎, 澤智裕, 本橋ほづみ, 赤池孝章. Mitochondrial energy metabolism and host defense mechanism regulated by supersulfide. 日本細菌学雑誌(Web). 2022. 77. 1
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井田智章, 松永哲郎, 高田剛, 守田匡伸, JUNG Minkyung, 澤智裕, 本橋ほづみ, 赤池孝章. Supersulfide host defense and its omics development. 日本生体防御学会学術総会講演抄録集. 2021. 32nd
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井田智章, 松永哲郎, 高田剛, 守田匡伸, JUNG Minkyung, 澤智裕, 本橋ほづみ, 赤池孝章. 超硫黄代謝物解析と呼気オミックスへの展開. 日本生化学会大会(Web). 2021. 94th
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吉田真彰, 松永哲郎, 高田剛, 井田智章, 筒井正人, 守田匡伸, 澤智裕, 赤池孝章. Host defense mechanism by nitric oxide and super sulfide in Salmonella infection. 日本細菌学雑誌(Web). 2021. 76. 1
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松永哲郎, 高田剛, 井田智章, 筒井正人, 守田匡伸, 澤智裕, 赤池孝章. Host defense mechanism by nitric oxide and supersulfides in Salmonella infection. 日本生体防御学会学術総会講演抄録集. 2021. 32nd
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Patents (5)：
Lectures and oral presentations (51)：
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蛋白質S-グアニル化とレドックスシグナル伝達制御
(第39回蛋白質と酵素の構造と機能に関する九州シンポジウム 2015)
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大腸菌における蛋白質S-グアニル化の制御因子と標的タンパク質の同定
(第68回日本細菌学会九州支部総会第52回日本ウイルス学会九州支部総会 2015)
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ヒト内在性レトロウイルスの転写因子の同定
(第68回日本細菌学会九州支部総会第52回日本ウイルス学会九州支部総会 2015)
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細菌におけるシステインパースルフィドおよび関連分子の生成動態
(第68回日本細菌学会九州支部総会第52回日本ウイルス学会九州支部総会 2015)
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蛋白質S-グアニル化と活性酸素シグナル伝達
(日本プロテオーム学会2015年会 JHUPO第13回大会 2015)
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Works (16)：
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細菌における活性イオウ分子の代謝機構とその抗菌剤感受性制御の分子基盤
2015 - 2018
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タンパク質ポリチオール化の制御機構の解明
2014 - 2016
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内因性親電子物質を介するレドックスシグナル伝達の制御メカニズム
2012 - 2015
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活性酸素シグナル受容体タンパク質の分子制御
2008 - 2013
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一酸化窒素(NO)によるゲノム修飾と制御の分子基盤の解明に向けた研究
2005 - 2008
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Education (6)：
Professional career (1)：
- Doctor of Engineering (Kyoto University)
Work history (16)：
- 2013 - 2014 東北大学大学院医学研究科環境保健医学分野 准教授
- 2013 - 2014 Associate Professor
- 2011 - 2014 Japan Science and Technology Agency
- 2011 - 2014 Researcher,Japan Science and Technology Agency
- 2014 - Kumamoto University Faculty of Life Sciences
- 2014 - Professor,Faculty of Life Sciences(Basic medicine group),Kumamoto University
- 2010 - 2013 Kumamoto University Faculty of Life Sciences
- 2010 - 2013 Associate Professor,Faculty of Life Sciences(Basic medicine group),Kumamoto University
- 2007 - 2009 准教授
- 2007 - 2009 Associate Professor,
- 2005 - 2007 助手
- 2005 - 2007 Research Associate,
- 2002 - 2005 WHO国際がん研究機関 研究員
- 2002 - 2005 Researcher
- 1996 - 2002 助手
- 1996 - 2002 Research Associate,
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Committee career (1)：
Association Membership(s) (3)：
日本細菌学会
, 日本癌学会
, Japanese Cancer Association
