ISHII Ken J

イシイケン | ISHII Ken J

Affiliation and department：
Job title： Professor
Other affiliations (1)：

The Institute of Medical Science, The University of Tokyo International Vaccine Design Center Director

Homepage URL (1)： http://www.vaccine-science.ims.u-tokyo.ac.jp/

Research field (4)： Immunology , Parasitology , Cell biology , Molecular biology

Research keywords (14)： Clinical trial , アジュバント , 核酸医薬 , ワクチン , 感染症 , 免疫学(自然免疫) , Nucleic Acids , Influenza virus , Malaria , Infectious Diseases , Innate immunity , Adjuvant , Vaccine , Immunology

Research theme for competitive and other funds (9)：

2022 - 2027 Innovative vaccine evaluation system for 100 days mission
2018 - 2024 Immune response to, and regulation by, extracellular nucleic acids
2020 - 2023 Preclinical study of near-infrared photoimmunotherapy for pancreatic cancer that incorporates nanoparticulate TLR9 agonist K3-SPG
2012 - 2017 'Development of a database to evaluate adjuvant safety'
免疫システムによる核酸認識機構の解明

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Papers (211)：

Tatsuo Ueda, Takumi Adachi, Tomoya Hayashi, Koubun Yasuda, Kazufumi Matsushita, Eiko Koike, Rie Yanagisawa, Takahiro Nagatake, Jun Kunisawa, Ken J. Ishii, et al. Bisphenol A triggers activation of ocular immune system and aggravates allergic airway inflammation. Clinical Immunology. 2024. 268. 110370-110370
Jalal Alshaweesh, Rashmi Dash, Michelle S J Lee, Pinar Kahyaoglu, Ece Erci, Mengling Xu, Julia Matsuo-Dapaah, Camila Del Rosario Zorrilla, Kubra Aykac, Suheyla Ekemen, et al. MyD88 in osteoclast and osteoblast lineages differentially controls bone remodeling in homeostasis and malaria. International immunology. 2024. 36. 9. 451-464
Norifumi Iijima, Tomoya Hayashi, Masaaki Niino, Yoichi Miyamoto, Masahiro Oka, Ken J Ishii. Tridecylcyclohexane in incomplete Freund's adjuvant is a critical component in inducing experimental autoimmune diseases. European journal of immunology. 2024. e2350957
Michelle Sue Jann Lee, Julia Matsuo-Dapaah, Camila Del Rosario Zorrilla, Yoshiki Omatsu, Takashi Nagasawa, Shun Uemura, Atsushi Iwama, Ken J Ishii, Cevayir Coban. Acute malaria suppresses the B lymphocytic niche in the bone marrow through the alteration of CXCL12-abundant reticular cells. International Immunology. 2024
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, et al. A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages. Cell Reports. 2024. 43. 4. 113981-113981

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MISC (295)：

根岸英雄, 和田雄佑, 石井健. ウイルス感染におけるZBP1とPANoptosis-ZBP1 and PANoptosis in viral infection. 臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会編. 2022. 77. 6. 758-763
小檜山康司, 石井健. 補助に終わらない免疫アジュバント-Vaccine adjuvants as cancer immunotherapeutic and immunoprophylaxis agents-特集腫瘍免疫 : 免疫ネットワークから考える基礎と臨床 ; 免疫チェックポイント阻害薬の成功から続く展望 ; 新規治療法. 医学のあゆみ. 2022. 281. 5. 515-521
Ishii K. Disruptive Innovation of Vaccine R&D during the COVID-19 Era. Nihon Kikan Shokudoka Gakkai Kaiho. 2022. 73. 2. 52-53
日置仰, 石井健. TLR刺激によるがん免疫応答の増強-Enhancement of anti-cancer immune response via TLR stimulation-特集がん免疫療法研究の進歩 ; がん免疫療法にかかわる環境因子. 腫瘍内科 = Clinical oncology / 腫瘍内科編集委員会編. 2022. 29. 2. 206-212
イシイケン. はじめに. 2021. 279. 10. 917-919

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Patents (34)：

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Books (9)：

「特集」RNAワクチンの先の基礎研究
羊土社 2022 ISBN:9784758125536
近未来のワクチン : 開発研究の潮流と課題
医歯薬出版 2018
次世代アジュバント開発のためのメカニズム解明と安全性評価
シーエムシー出版 2017 ISBN:9784781312385
Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology
Academic Press 2013 ISBN:0124047327
実験医学増刊 Vol.30 No.20 感染・共生・生体防御システム〜ウイルス・細菌と宿主のクロストークからワクチン開発を始めとする予防戦略まで (実験医学増刊 Vol. 30-20)
羊土社 2012 ISBN:4758103275

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Professional career (1)：

M.D., Ph.D.

Work history (17)：

2023/04 - 現在 The University of Tokyo UTOPIA Center Vice Director
2022/04 - 現在 The Institute of Medical Science, The University of Tokyo International Vaccine Design Center Director
2019/01 - 現在 The Institute of Medical Science, The University of Tokyo Division of Vaccine Science, Department of Microbiology and Immunology Professor
2010/04 - 現在 Lab. Vaccine Science, WPI Immunology Frontier Research Center (iFREC), Osaka University Visiting Professor
2019/04 - 2022/03 The Institute of Medical Science, The University of Tokyo International Research and Development Center for Mucosal Vaccines Director

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Committee career (3)：

2009 - 2019 (独)医薬品医療機器総合機構(PMDA) 生物審査第2部専門委員
2015 - 2017 日本医療研究開発機構(AMED) 戦略推進部長
2008 - 2010 文部科学省・研究振興局・学術調査官

Awards (9)：

2019/12 - Japanese Society of Immunology JSI award
2014/10 - Osaka Science Prize
2011 - 第35回多ヶ谷勇記念ワクチン研究奨励賞
2008 - 大阪大学研究教育功労賞
2008 - 日本免疫学会研究奨励賞

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Association Membership(s) (5)：

International Society for Vaccines , 日本ワクチン学会 , 日本寄生虫学会 , 米国免疫学会 , 日本免疫学会

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