Inoue Yusuke

イノウエユウスケ | Inoue Yusuke

Affiliation and department：
Job title： Associate Professor

Research field (3)： Molecular biology , Cell biology , Genetics

Research keywords (20)：代謝 , 糖尿病 , 転写因子 , 核内レセプター , RNA , ノックアウトマウス , 肝臓 , PPARalpha , C/EBPalpha , HNF4alpha , metabolism , diabetes , transcriptin factor , nuclear receptor , RNA , knockout mice , liver , PPARalpha , C/EBPalpha , HNF4alpha

Research theme for competitive and other funds (17)：

2023 - 2026 前立腺癌の去勢抵抗性獲得メカニズムとリン酸化核内受容体の病態解明
2018 - 2023 がん抑制に関わる選択的スプライシング制御蛋白質の標的遺伝子の同定と認識機構の解明
2019 - 2022 Mechanism of NASH pathogenesis by nuclear receptors through qualitative changes in fatty acids
2017 - 2021 The role of nuclear receptor CAR in the pathogenesis of intrahepatic cholangiocellular carcinoma
2016 - 2019 核内受容体HNF4αとPPARによるNASH発症機序の解明と治療応用への基礎研究

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Papers (92)：

Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, et al. Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface. Frontiers in Oncology. 2024. 14
Daisuke Hirabayashi, Ken-ichi Yamamoto, Akihiro Maruyama, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Ni Luh Gede Yoni Komalasari, Hitoshi Murata, Yuma Gohara, Fan Jiang, et al. LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells. Frontiers in Oncology. 2023. 13
Carlos Ichiro Kasano-Camones, Masayuki Takizawa, Noriyasu Ohshima, Chinatsu Saito, Wakana Iwasaki, Yuko Nakagawa, Yoshio Fujitani, Ryo Yoshida, Yoshifumi Saito, Takashi Izumi, et al. PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice. The Journal of Biochemistry. 2023. 173. 5. 393-411
Ni Luh Gede Yoni Komalasari, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Yoshihiko Sakaguchi, Yuma Gohara, Fan Jiang, Ken-Ich Yamamoto, Hitoshi Murata, I Made Winarsa Ruma, et al. Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2. Frontiers in oncology. 2023. 13. 1142907-1142907
Acosta Gonzalez Herik Rodrigoab, Nahoko Tomonobua, HarukaYoneda, Rie Kinoshita, Yosuke Mitsui, Takuya Sadahira, Shin-ichi Terawaki, Yuma Gohara Ni LuhGede Yoni Komalasari, Fan Jiang, Hitoshi Murata, et al. Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation. Biochemical and Biophysical Research Communications. 2022. 634. 83-91

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MISC (91)：

Hiroto Fujita, Yusuke Inoue, Masayasu Kuwahara. Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer. Bioorganic and Medicinal Chemistry Letters. 2018. 28. 1. 35-39
Morimoto, Aoi, Kannari, Mana, Tsuchida, Yuichi, Sasaki, Shota, Saito, Chinatsu, Matsuta, Tsuyoshi, Maeda, Tsukasa, Akiyama, Megumi, Nakamura, Takahiro, Sakaguchi, Masakiyo, et al. An HNF4-microRNA-194/192 signaling axis maintains hepatic cell function. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 25. 10574-10585
Enomoto, Rina, Kurosawa, Aya, Nikaido, Yoshiaki, Mashiko, Misaki, Saheki, Toshihiko, Nakajima, Nozomi, Kuroiwa, Satoshi, Otobe, Michinari, Ohsaki, Maki, Tooyama, Kazuya, et al. A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test. EUROPEAN JOURNAL OF PHARMACOLOGY. 2017. 814. 130-137
Putranto, Endy Widya, Kinoshita, Rie, Watanabe, Masami, Sadahira, Takuya, Murata, Hitoshi, Yamamoto, Ken-Ichi, Futami, Junichiro, Kataoka, Ken, Inoue, Yusuke, et al. Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene. ONCOLOGY LETTERS. 2017. 14. 1. 1041-1048
Satomi Saho, Hiroki Satoh, Eisaku Kondo, Yusuke Inoue, Akira Yamauchi, Hitoshi Murata, Rie Kinoshita, Ken-Ichi Yamamoto, Junichiro Futami, Endy Widya Putranto, et al. Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells. Cancer microenvironment : official journal of the International Cancer Microenvironment Society. 2016. 9. 2-3. 93-105

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Lectures and oral presentations (26)：

Positive regulation of hepatic miRNA by HNF4α
(3rd international symposium of GUMI&AMDE 2016 2016)
PPARαカスケードの活性化による脂肪肝の発症
(第39回日本分子生物学会 2016)
肝臓特異的HNF4α欠損マウスの血糖値低下機構の解析
(第39回日本分子生物学会 2016)
HNF4αによる肺がん形成、進行への影響
(第39回日本分子生物学会 2016)
Positive regulation of hepatic miRNA by HNF4α
(3rd international symposium of GUMI&AMDE 2016 2016)

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Professional career (1)：

条件付 (Okayama University)

Work history (6)：

2021 - 現在 Gunma University
2013 - 2021 Gunma University
2007 - 2013 Gunma University
2005 - 2007 Gunma University
2000 - 2005 National Institute of Health National Cancer Institute

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Awards (5)：

2016 - 優秀ポスター賞
2005 - The Fellows Award For Research Excellence 2005
2005 - The Fellows Award For Research Excellence 2005
2003 - The Fellows Award For Research Excellence 2003
2003 - The Fellows Award For Research Excellence 2003

Association Membership(s) (8)：

American Society for Biochemistry and Molecular Biology , American Society for Microbiology , 日本RNA学会 , 肝細胞研究会 , 日本分子生物学会 , American Society for Biochemistry and Molecular Biology , American Society for Microbiology , The Molecular Biology Society of Japan

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