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J-GLOBAL ID：201702234952866522   Reference number：17A1557261

A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test

GPBAの新規部分作動薬はマウスのグルコース負荷試験における血糖値を減少させる【Powered by NICT】

Author (22)： Enomoto Rina (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Kurosawa Aya (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Nikaido Yoshiaki (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Mashiko Misaki (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Saheki Toshihiko (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Nakajima Nozomi (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Kuroiwa Satoshi (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Otobe Michinari (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Ohsaki Maki (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Tooyama Kazuya (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Inoue Yusuke (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan) ,  Kuwabara Nobuo (Gunma Sericultural Technology Center, 2326-2 Soja, Soja-machi, Maebashi, Gunma 371-0852, Japan) ,  Kikuchi Osamu (Institute for Molecular and Cellular Regulation, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan) ,  Kitamura Tadahiro (Institute for Molecular and Cellular Regulation, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan) ,  Kojima Itaru (Institute for Molecular and Cellular Regulation, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan) ,  Nakagawa Yuko (Institute for Molecular and Cellular Regulation, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan) ,  Saito Tamio (Collaboration Promotion Unit, Global Research Cluster, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Saito Tamio (Chemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Osada Hiroyuki (Chemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Futahashi Mizuko (Transgenic Silkworm Research Center, National Institute of Agrobiological Sciences, 1-2 Owashi, Tsukuba, Ibaraki 305-8634, Japan) ,  Sezutsu Hideki (Transgenic Silkworm Research Center, National Institute of Agrobiological Sciences, 1-2 Owashi, Tsukuba, Ibaraki 305-8634, Japan) ,  Takeda Shigeki (Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan)
Material： European Journal of Pharmacology  (Eur J Pharmacol)
Volume： 814  Page： 130-137  Publication year： 2017 
JST Material Number： B0841A  ISSN： 0014-2999  CODEN： EJPHAZ  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： GPBA is a G protein-coupled re...

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Thesaurus term： insulin ,  Cell Membrane ,  bile acid ,  therapy ,  HEK293 cell ,  Metabolism ,  *glucose tolerance test ,  fusion protein ,  *Blood Glucose ,  effect concentration 50 ,  transgenic silkworm ,  G protein-coupled receptor ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug ,  Endomembrane system ,  adenine nucleotide ,  ribonucleotide ,  cyclic nucleotide
Semi thesaurus term： アゴニスト ,  *部分作動薬 , 【Automatic Indexing@JST】

Author keywords (6)： G protein coupled receptor ,  Bile acid receptor ,  High-throughput screening ,  Receptor-Gα fusion protein ,  Transgenic silkworm ,  Glucose tolerance test

JST classification (3)： Basic research of psychotropic drugs  (GW03100Y) ,  Basic research of addictive analgesics and narcotics  (GW03080Z) ,  Receptors on cell membrane  (EF04030C)

Substance index (1)： cAMP

Terms in the title (4)： 部分作動薬 ,  マウス ,  グルコース負荷試験 ,  血糖値