2019 - 2022 Significance of mTOR signaling in the pathogenesis of Fuchs endothelial corneal dystrophy
2016 - 2019 Involvement of endoplasmic reticulum stress in the pathophysiology of Fuchs endothelial corneal dystrophy
2016 - 2019 Fuchs角膜内皮ジストロフィの病態生理における小胞体ストレス応答の意義
2014 - 2019 難治性角膜疾患に対するトランスレーショナル研究の推進と国際的研究拠点の形成
2015 - 2018 The effect of TGC triplet repeat expansion on the pathophysiology of Fuchs endothelial corneal dystrophy
2014 - 2016 Investigation of molecular mechanism of cellular-senescence of corneal endothelial cells in association with cell-culture and its application for corneal endothelial tissue engineering
2010 - 2012 Three dimensional microstructure of spinal endplate: relationship between nano-scale structure of nutrition canal and biochemical characteristics of intervertebral disc
2010 - 2011 特発性角膜内皮炎の実態把握と診断法確立のための研究
2009 - 2011 角膜移植の治療成績を向上させる新しいドナー角膜保存液の開発
2008 - 2011 多糖類アルジネートを用いた角膜内皮再生医療の開発
2006 - 2008 霊長類角膜内皮細胞の増殖制御機構の解明
2006 - 2007 霊長類角膜内皮細胞の増殖制御機構の解明
2004 - 2005 培養ヒト角膜内皮細胞シート自家移植の臨床応用を目指した開発
2004 - 2005 Ocular surface疾患の予後を予測できるプロテインチップの開発
難治性眼表面疾患に対する角膜再生医療の研究
Study on Regenerative Medicine for Severe Ocukar Surface Diseases
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Papers (164):
Naoki Okumura, Takeru Nishikawa, Chiaki Imafuku, Yuki Matsuoka, Yuna Miyawaki, Shinichi Kadowaki, Makiko Nakahara, Yasushi Matsuoka, Noriko Koizumi. U-Net Convolutional Neural Network for Real-Time Prediction of the Number of Cultured Corneal Endothelial Cells for Cellular Therapy. Bioengineering (Basel, Switzerland). 2024. 11. 1
Tatsuya Nakagawa, Naoki Okumura, Masaya Ikegawa, Yumiko Toyama, Takashi Nirasawa, Frederic Mascarelli, Hanielle Vaitinadapoule, Ines Aouimeur, Zhiguo He, Philippe Gain, et al. Shotgun proteomics identification of proteins expressed in the Descemet's membrane of patients with Fuchs endothelial corneal dystrophy. Scientific reports. 2023. 13. 1. 10401-10401
Hidenobu Tanihara, Tetsuya Yamamoto, Makoto Aihara, Noriko Koizumi, Hiroomi Minami, Satoshi Kojima, Tomoyuki Isobe, Mizuho Kanazawa, Hideki Suganami. Crossover Randomized Study of Pharmacologic Effects of Ripasudil-Brimonidine Fixed-Dose Combination Versus Ripasudil or Brimonidine. Advances in therapy. 2023
Yasufumi Tomioka, Koji Kitazawa, Hideki Fukuoka, Morio Ueno, Noriko Koizumi, Chie Sotozono, Shigeru Kinoshita. Twelve-year outcome of Rho-associated protein kinase inhibitor eye drop treatment for Fuchs endothelial corneal dystrophy: A case study. American journal of ophthalmology case reports. 2023. 30. 101839-101839