Shimizu Takeyuki

シミズタケユキ | Shimizu Takeyuki

Affiliation and department：
Job title： Associate Professor

Research field (3)： Immunology , Medical biochemistry , Functional biochemistry

Research keywords (4)：分子生物学 , 免疫学 , molecular biology , Immunology

Research theme for competitive and other funds (9)：

2018 - 2021 Analysis of endothelial cells presenting antigens to helper T cells in tumor microenvironment
2011 - 2013 Analysis of structural and functional changes in immunoglobulins during the maturation of the immune response
2008 - 2010 Mechanisms of host defense against pulmonaryinfection, inflammation and injury by surfactant proteins and studies on clinical applications
2008 - 2010 Analysis of the interactions of collectins with immunoglobuins and the regulation immunoglobulin functions
2007 - 2008 Surfactant protein regulates the activity of matrix metalloproteineses

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Papers (57)：

Takeyuki Shimizu, Lin Sun, Kazuo Ohnishi. Influence of pre-B cell receptor deficiency on the immunoglobulin repertoires in peripheral blood B cells before and after immunization. Molecular Immunology. 2024. 166. 87-100
Gert-Jan Bekker, Nobutaka Numoto, Maki Kawasaki, Takahiro Hayashi, Saaya Yabuno, Yuko Kozono, Takeyuki Shimizu, Haruo Kozono, Nobutoshi Ito, Masayuki Oda, et al. Elucidation of binding mechanism, affinity and complex structure between mWT1 tumor-associated antigen peptide and HLA-A*24:02. Protein Science. 2023. 32. 10. e4775
Eiji Yuba, Yoshikatsu Sugahara, Yuta Yoshizaki, Takeyuki Shimizu, Michiyuki Kasai, Keiko Udaka, Kenji Kono. Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses. Biomaterials Science. 2021. 9. 8. 3076-3089
Toshihiro Komatsu, Takeyuki Shimizu, Makoto Kanoh, Tomoya Miyakawa, Yoko Satta, Yoshiki Yasukochi, Rika Fujimoto, Motoki Tada, Kaori Machida, Sayo Kataoka, et al. Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion. Immunogenetics. 2020. 72. 3. 143-153
Tashiro Y, Murakami A, Hara Y, Shimizu T, Kubo M, Goitsuka R, Kishimoto H, Azuma T. High-affinity IgM⁺ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen. Scientific Reports. 2018. 8. 1. 14559

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MISC (41)：

Y. Tashiro, A. Murakami, T. Shimizu, R. Goitsuka, H. Kishimoto, T. Azuma. High-affinity IgM(+) memory B cells are deficient in terminal differentiation potential to secrete IgM antibodies by restimulation with (4-hydroxy-3-nitrophenyl) acetyl-chicken gamma-globulin. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 1147-1147
TASHIRO Yasuyuki, MURAKAMI Akikazu, GOITSUKA Ryo, SHIMIZU Takeyuki, KISHIMOTO Hidehiro, AZUMA Takachika. An asymmetric antibody repertoire is shaped between plasmablasts and plasma cells after secondary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken γ-globulin. 日本免疫学会総会・学術集会記録. 2015. 44. Proceedings
TASHIRO Yasuyuki, HARA Yasushi, MURAKAMI Akikazu, SHIMIZU Takeyuki, AZUMA Takachika. Germinal center reaction actively induces somatic hypermutation in IgM but down-regulates class switch recombination. 日本免疫学会総会・学術集会記録. 2013. 42. Proceedings
西谷千明, 有木茂, 高橋素子, 栗村雄一郎, 斎藤充史, 長谷川喜弘, 清水健之, 黒木由夫. 酸化肺サーファクタントリン脂質によるLPS惹起炎症応答抑制機構. エンドトキシン・自然免疫研究. 2011. 14. 43-45
HARA Yasushi, MURAKAMI Akikazu, NISHIMURA Miyuki, SHIMIZU Takeyuki, AZUMA Takachika. IgM+ memory B cells involved in immune response to a T cell dependent antigen. 日本免疫学会総会・学術集会記録. 2011. 40

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Lectures and oral presentations (28)：

Influences of pre-B cell receptor deficiency on repertoires of naive immunoglobulin heavy and light chains and of antigen-responding heavy chains in peripheral blood B cells
(2024)
Antigen presentation and helper T cell activation by MHC class II-binding peptide immunization in a micelle formula
(2022)
Efficient induction of effector T cells by peptide immunization in a micelle formula
(2021)
ゲノム編集によるTAP欠損細胞を使ったMHCクラスI分子と抗原ペプチドの結合相互作用解析法
(第23回日本がん免疫学会総会 2019)
Construction of a TAP deficient HLA class I-binding assay system with the use of CRISPR/Cas9 system
(2017)

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Education (4)：

Professional career (1)：

Work history (11)：

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Association Membership(s) (7)：

日本がん免疫学会 , 日本生化学会 , 日本免疫学会 , 日本分子生物学会 , The Japanese Biochemical Society , Japanese Society for Immunology , The Molecular Biology Society of Japan

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