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J-GLOBAL ID：202002286737124633   Reference number：20A0712976

Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion

立体配座依存性ではなく,ペプチド無差別な様式において最もHLA-Aアロモルフに結合する新規モノクローナル抗体の開発【JST・京大機械翻訳】

Author (14)： Komatsu Toshihiro (Department of Immunology, Kochi University, Kochi, Japan) ,  Shimizu Takeyuki (Department of Immunology, Kochi University, Kochi, Japan) ,  Kanoh Makoto (Department of Immunology, Kochi University, Kochi, Japan) ,  Miyakawa Tomoya (Corporate Business Development Division, NEC, Tokyo, Japan) ,  Satta Yoko (Department of Evolutionary Studies of Biosystems, SOKENDAI (The Graduate University for Advanced Studies), Hayama, Japan) ,  Yasukochi Yoshiki (Department of Evolutionary Studies of Biosystems, SOKENDAI (The Graduate University for Advanced Studies), Hayama, Japan) ,  Yasukochi Yoshiki (Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu, Japan) ,  Fujimoto Rika (Department of Immunology, Kochi University, Kochi, Japan) ,  Fujimoto Rika (Research Institute at Kanagawa Cancer Centre, Yokohama, Japan) ,  Tada Motoki (Department of Immunology, Kochi University, Kochi, Japan) ,  Tada Motoki (Japan Manned Space Systems Corporation, Tokyo, Japan) ,  Machida Kaori (Department of Immunology, Kochi University, Kochi, Japan) ,  Kataoka Sayo (Science Research Center, School of Medicine, Kochi University, Kochi, Japan) ,  Udaka Keiko (Department of Immunology, Kochi University, Kochi, Japan)
Material： Immunogenetics
Volume： 72  Issue： 3  Page： 143-153  Publication year： 2020 
JST Material Number： D0132B  ISSN： 0093-7711  CODEN： IMNGBK  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Specificity analyses...

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Thesaurus term： peptide bond ,  chaos ,  human leucocyte antigen ,  Amino Acid Sequence ,  *monoclonal antibody ,  gene ,  *HLA-A ,  *peptide ,  gene expression ,  *steric conformation ,  epitope ,  diversification ,  Cell Line ,  European Continental Ancestry Group ,  molecular genetic phenomenon
Semi thesaurus term： 白人 ,  特異性 , 【Automatic Indexing@JST】

Author keywords (5)： Monoclonal antibody ,  HLA-A ,  Locus-specific ,  Peptide-promiscuous ,  Conformational epitope

JST classification (2)： Immunological reaction in general  (ED03010T) ,  Bioassay  (EA03060N)

Terms in the title (7)： 立体配座 ,  依存性 ,  ペプチド ,  様式 ,  HLA-A ,  モノクローナル抗体 ,  開発