Nakanishi Makoto

ナカニシマコト | Nakanishi Makoto

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.ims.u-tokyo.ac.jp/cancer-cell-biology/hp2018/01index.html

Research field (1)： Tumor biology

Research theme for competitive and other funds (4)：

2022 - 2028 生命科学連携推進協議会
2024 - 2026 Senescent cell niche: Analysis of the Aging of bone regenerative capacity in skeletal stem cells
2023 - 2026 Senescent cell niche: Analysis of aging mechanism of bone regeneration capacity in skeletal stem cells
2024 - 2025 Mechanisms underlying replication of non-genomic codes that mediate plasticity and robustness for cellular inheritance

Papers (142)：

Yue Zhang, Teh-Wei Wang, Maho Tamatani, Xinyi Zeng, Lindo Nakamura, Satotaka Omori, Kiyoshi Yamaguchi, Seira Hatakeyama, Eigo Shimizu, Satoshi Yamazaki, et al. Signaling networks in cancer stromal senescent cells establish malignant microenvironment. Proceedings of the National Academy of Sciences of the United States of America. 2025. 122. 14. e2412818122
Satoru Meguro, Yoshikazu Johmura, Teh-Wei Wang, Satoshi Kawakami, Shota Tanimoto, Satotaka Omori, Yuki T Okamura, Seiji Hoshi, Emina Kayama, Kiyoshi Yamaguchi, et al. Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion. Nature aging. 2024
Xinyi Zeng, Teh-Wei Wang, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Yoshikazu Johmura, Makoto Nakanishi. M2 macrophage-derived TGF-β induces age-associated loss of adipogenesis through progenitor cell senescence. Molecular metabolism. 2024. 84. 101943-101943
Satoshi Kawakami, Yoshikazu Johmura, Makoto Nakanishi. Intracellular acidification and glycolysis modulate inflammatory pathway in senescent cells. The Journal of Biochemistry. 2024
Kojiro Suda, Yohsuke Moriyama, Nurhanani Razali, Yatzu Chiu, Yumiko Masukagami, Koutarou Nishimura, Hunter Barbee, Hiroshi Takase, Shinju Sugiyama, Yuta Yamazaki, et al. Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts. Nature Aging. 2024. 4. 3. 319-335

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MISC (109)：

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Patents (2)：

Books (1)：

Lectures and oral presentations (91)：

Senescent cancer stromal cells, a major player, not a player in the back seat
(50th Annual Meeting of Korean Cancer Association 2024)
老化細胞による炎症・線維化病態
(第60回日本肝臓学会総会 2024)
加齢に伴う臓器線維化の分子基盤
(第24回日本抗加齢医学学会総会 2024)
慢性炎症を標的に老化を改善する
(第59回日本臨床分子医学会学術集会 2024)
Role of stromal p16-positive cells in cancer progression
(2024)

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Works (2)：

細胞周期制御因子を標的とした抗ガン剤の開発
2000 - 2001
Development of neural anti-cancer drug targeting cell cycle regulators
2000 - 2001

Education (4)：

Professional career (1)：

Work history (9)：

2016/04 - 現在 The Institute of Medical Science The University Tokyo Division of Cancer Cell Biology Department of Cancer Biology Professor
1998 - 2000 Nagoya City University
1998 - 2000 Associate
1996 - 1998 国立長寿医療研究センター
1996 - 1998 Chief.

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Awards (3)：

2024/11 - 公益財団法人持田記念医学薬学振興財団持田記念学術賞受賞
2023 - Ministry of Education, Culture, Sports, Science and Technology The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (Research Category)
2000 - 日本生化学会奨励賞

Association Membership(s) (3)：

日本癌学会 , 日本分子生物学会 , 日本生化学会

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