Rchr
J-GLOBAL ID：200901066390783387
Update date: Mar. 30, 2024
Mazda Osam
マツダ オサム | Mazda Osam
Affiliation and department：
Job title：
Professor
Research field (2)：
Immunology
, Medical biochemistry
Research keywords (4)：
Epigenetics
, Allergy
, 再生医学
, 免疫学
Research theme for competitive and other funds (70)：
- 2023 - 2026 ラマン分光法を用いた口腔バイオフィルムの分子構造解析と高感度な迅速診断法の開発
- 2023 - 2026 Rapid diagnosis of COVID-19 and fungal infections using Raman barcodes
- 2023 - 2026 Development of broad-spectrum antiviral compounds derived from foods
- 2022 - 2025 Development of direct reprogramming skeletal muscle cell sheet for diaphragmatic hernia
- 2022 - 2025 Effects of dietary components on SARS-CoV-2 infection
- 2021 - 2024 Development of injectable adipose tissue ball (iPAT) for establishment of new breast reconstruction method
- 2021 - 2024 In vivo regenerative treatment of interstitial cystitis by direct reprogramming
- 2021 - 2024 Development of the next generation OA hyperthermia using a novel photothermal DDS
- 2021 - 2024 Development of novel cell therapy for autoimmune diseases using iPS cell-derived tolerogenic dendritic cells
- 2021 - 2024 Genetic studies on tumor suppression by innate immune system in Drosophila
- 2021 - 2024 Establishment of a new exercise therapy for osteoarthritis using HIF-1alpha regulation by hypoxia
- 2021 - 2024 Differential regulation of TGFR family signaling and bone and cartilage tissue regeneration
- 2021 - 2024 Small compounds driven direct conversion of functional human MSC
- 2021 - 2023 Regenerative therapeutics of bone diseases by means of in situ direct reprogramming
- 2020 - 2023 低酸素環境での新規分子HYBIDの制御による変形性関節症治療法の開拓
- 2020 - 2023 Development of fetal therapy of congenital diaphragmatic hernia by intra-amniotic injection of exosomes derived from mesenchymal stem cells
- 2020 - 2023 架橋ナノゲルを用いた骨・軟骨オルガノイドの構築と量子ビームによるナノ構造解析
- 2019 - 2023 Development of novel GD2 antibody-producing mesenchymal stem cell therapy against neuroblastoma using mouse model
- 2019 - 2023 生体アパタイトの配行性・結晶性を有した骨オルガノイドの構築と臨床応用への展開
- 2018 - 2023 培養3次元軟骨組織の構築と非破壊的解析技術による軟骨再生医療
- 2019 - 2022 Regeneration of bladder smooth muscle by in vivo direct reprogramming
- 2019 - 2022 Development of functional muscle sheet using direct conversion technique and iBTA
- 2018 - 2022 Application of directly converted osteoblasts to disease model animals
- 2019 - 2021 Regeneration of bone and cartilage tissues by means of chemical direct reprogramming
- 2018 - 2021 Development of functional Schwann cell induction technology using small molecule compounds and expansion regenerative medicine
- 2017 - 2020 Bone regeneration and clinical application using the hybrid nanogel scaffolds
- 2017 - 2020 Mechanisms of the osteoblast-like phenotypic conversion and its application to regenerative therapy of bone diseases
- 2017 - 2020 Osteoinductivity and osteoconductivity of non-oxide ceramics
- 2015 - 2020 Living Matter as a Super Parallel Autonomous System
- 2015 - 2019 Novel Schwann cell induction method for cell transplantation treatment for peripheral nerve injury
- 2015 - 2019 The novel cell therapy for neuroblastoma by engineered stem cell
- 2017 - 2019 Bone regeneration therapy using direct reprogrammed osteoblastic cells and siRNA/Nonogel complex
- 2016 - 2018 Chemical induction of brown adipocytes and regeneration therapy for diabetes
- 2016 - 2018 Role of mast cells in adipose-derived chronic inflammation
- 2015 - 2018 Development of new OA therapy targeting HIF-1a
- 2015 - 2018 Establishment of heredital desease models using iPS cells and genome editing
- 2016 - 2017 Creation of single cell and real-time observation technology of virus infection based on genome modification
- 2014 - 2017 Pathogenesis and regenerative therapy of osteoporosis
- 2015 - 2016 Regeneration therapy of metabolic diseases based on chemical direct reprogramming of somatic cells
- 2015 - 2016 Three-dimensional culture of reprogrammed brown adipocytes
- 2015 - 2016 Development of a molecule control in allergic rhinitis by a delivery of an artificial transcription factor
- 2012 - 2016 New development of the molecular targeted therapy for osteoarthritis arthritis with respect to stress-response mechanism
- 2014 - 2015 Regenerative therapy for metabolic diseases based on chemical direct reprogramming
- 2010 - 2015 Development of cancer-controlling vector conversion techniques using nano-DDS
- 2013 - 2014 Bone regeneration based on direct reprogramming technologies
- 2012 - 2012 Analyses of soluble factors produced by human brown adipocytes
- 2012 - 2012 Exploration of components that may stimulate innate immune responses in traditional fermented products
- 2011 - 2011 Network regulation of brown adipocyte lineages
- 2008 - 2010 Nano DDS-mediated cytokine delivery and control of allergic responses.
- 2008 - 2009 Development of nanocarrier for cancer immunotherapy
- 2005 - 2009 Multi-scale manipulation-based analyses and application of the artificial chromosome-like characteristics of the Epstein-Barr virus-based episomal vectors
- 2008 - 2008 RNAインターフェレンスを用いた分子標的筋再生療法の確立
- 2006 - 2007 癌免疫治療のための新規ナノゲルキャリアの開発
- 2005 - 2006 ナノキャリアー分子コンジュゲートを用いた癌の免疫サイトカイン療法
- 2005 - 2006 development of novel conservative therapies for joint disease under controlled HSP expression-usage of HSP-inducing agents and thermotherapy-
- 2005 - 2005 分子シャペロン機能を有するナノゲルキャリアによる新規DDSの開発
- 2004 - 2005 Molecular regulation of IgE allergy
- 2003 - 2004 Research for the gene therapy to the joint disorder using the hydrodynamics-based transfection method.
- 2003 - 2004 Electrochemo-gene therapy of Cancer using Epstein Barr virus-plasmid vector ; Intratumoral delivery of Interleukin-12 gene and bleomycin induce therapeutic immunity and suppressed subcutaneous and metastatic melanomas in mice
- 2002 - 2003 関節に対するin vivoエレクトロポレーション法を応用した遺伝子導入法の検討
- 2002 - 2003 Immuno-gene Therapy of Cancer by Interleukin-21 (IL-21)
- 2002 - 2003 Regenerative Gene Therapy of Diabetes Mellitus
- 2002 - 2003 Differentiation induction of adult somatic stem cells into cardiomyocytes
- 2001 - 2002 Development of EBV/polyplex as gene therapy against prostate cancer
- 2000 - 2001 Development of viral antigen specific immunotherapy for Epstein-Barr virus related gastric cancer.
- 2000 - 2001 Gene Therapy for the Recovery from Left Ventricular Assist System
- 2000 - 2001 Gene Therapy and Cell Therapy of Cancer by Means of the Interleukin-18 Gene Transfer
- 1999 - 2000 Xenotransplantation of ex vivo gene trandected cardiomyocytes
- 1997 - 1998 腫瘍細胞特異的に外来遺伝子を発現させる新しい遺伝子導入システムの開発
- 1997 - 1998 EB(エプスタイン・バール)ウイルス・ベクターによるヒト造血幹細胞への遺伝子導入
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Papers (148)：
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Adachi T, Tahara Y, Yamamoto K, Yamamoto T, Kanamura N, Kazunari Akiyoshi K, Mazda O. Cholesterol -Bearing Polysaccharide-Based Nanogels for Development of Novel Immunotherapy and Regenerative Medicine. Gels. 2024. 10. (3). 206-206
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Davide Redolfi-Bristol, Alessandro Mangiameli, Kenta Yamamoto, Elia Marin, Wenliang Zhu, Osam Mazda, Pietro Riello, Giuseppe Pezzotti. Ammonia Toxicity and Associated Protein Oxidation: A Single-Cell Surface Enhanced Raman Spectroscopy Study. Chemical Research in Toxicology. 2023. 37. 1. 117-125
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Giuseppe Pezzotti, Eriko Ohgitani, Hayata Imamura, Saki Ikegami, Masaharu Shin-Ya, Tetsuya Adachi, Keiji Adachi, Toshiro Yamamoto, Narisato Kanamura, Elia Marin, et al. Raman Multi-Omic Snapshot and Statistical Validation of Structural Differences between Herpes Simplex Type I and Epstein-Barr Viruses. International Journal of Molecular Sciences. 2023. 24. 21. 15567-15567
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Giuseppe Pezzotti, Eriko Ohgitani, Yuki Fujita, Hayata Imamura, Francesco Pappone, Alfio Grillo, Maiko Nakashio, Masaharu Shin-Ya, Tetsuya Adachi, Toshiro Yamamoto, et al. Raman Fingerprints of SARS-CoV-2 Omicron Subvariants: Molecular Roots of Virological Characteristics and Evolutionary Directions. ACS infectious diseases. 2023. 9. 11. 2226-2251
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Giuseppe Pezzotti, Eriko Ohgitani, Yuki Fujita, Hayata Imamura, Francesco Pappone, Alfio Grillo, Maiko Nakashio, Masaharu Shin-Ya, Tetsuya Adachi, Toshiro Yamamoto, et al. Raman Fingerprints of SARS-CoV-2 Omicron Subvariants: Molecular Roots of Virological Characteristics and Evolutionary Directions. ACS Infectious Diseases. 2023
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MISC (99)：
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足立哲也, 扇谷えり子, 宮本奈生, 新屋政春, 山本俊郎, PEZZOTTI Giuseppe, 松田修, 金村成智. 『見つける』・『清める』・『護る』の概念を取り入れたwith/postコロナ社会における安心・安全な環境づくり. 日本歯科医学会誌. 2022. 41
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Yoshiki Sato, Kenta Yamamoto, Shigeta Takizawa, Keiji Adachi, Fumishige Oseko, Takeshi Amemiya, Tsunao Kishida, Toshiro Yamamoto, Osam Mazda, Narisato Kanamura. Effects of using nanogel-cross-linked porous gel with cell adhesion factor for cell transplantation. JOURNAL OF IMMUNOLOGY. 2020. 204. 1
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足立哲也, 堀口智史, 堀口智史, 中井かおる, 山本俊郎, 松田修, PEZZOTTI Giuseppe, PEZZOTTI Giuseppe, 金村成智. 神経系細胞における神経突起を形成する分子のラマンイメージング. 日本抗加齢医学会総会プログラム・抄録集. 2019. 19th. 236
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堀口智史, 堀口智史, 足立哲也, 山本俊郎, PEZZOTTI Giuseppe, 松田修, 金村成智. 骨誘導と抗菌性を有する窒化ケイ素セラミックの口腔インプラントへの応用. 日本歯周病学会会誌(Web). 2018. 60. 131
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藤井 雄太, 井上 裕章, 新井 祐志, 中川 周士, 土田 真嗣, 下村 征史, 松田 修, 久保 俊一. トレッドミル走行がラット関節炎モデルの膝関節に与える組織学的評価. 日本整形外科学会雑誌. 2018. 92. 8. S1987-S1987
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Patents (11)：
Education (2)：
- 1989 - 1993 Kyoto University Graduate School of Medicine Department of Immunology
- 1979 - 1985 Kyoto Prefectural University of Medicine Faculty of Medicine
Professional career (1)：
Work history (8)：
- 2011/04 - 現在 Kyoto Prefectural University of Medicine Department of Immunology Professor
- 2008/06 - 2012/03 JST PRESTO researcher
- 2010/06 - 2011/03 Kyoto Prefectural University of Medicine Department of Immunology and Microbiology Professor
- 2007/04 - 2010/05 Kyoto Prefectural University of Medicine Department of Immunology and Microbiology Associate Professor
- 1999/06 - 2007/03 Kyoto Prefectural University of Medicine Department of Microbiology Associate Professor
- 1995/04 - 1999/05 Kyoto Prefectural University of Medicine Department of Microbiology Associate Professor
- 1994/10 - 1995/03 Kyoto Prefectural University of Medicine Department of Microbiology Assistant Professor
- 1993/04 - 1994/09 JSPS Research Fellow
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