Research field (2)：
Tumor biology
, Experimental pathology
Research keywords (2)：
Toxicologic Pathology
, Comparative Pathology
Research theme for competitive and other funds (6)：
2018 - 2021 芳香族アミンの膀胱に対する傷害性および発がん性における構造特性の影響
2016 - 2018 芳香族アミンの膀胱に対するin vivo遺伝毒性および細胞動態の短期解析
2014 - 2017 Roles of DNA damage and repair pathway in gastric carcinogenesis after eradication of Helicobacter pylori
2011 - 2013 Analysis of the origin of serum TFF3 as a biomarker for gastric cancer
2010 - 2012 Investigation of gastric cancer chemoprevention after Helicobacter pylori eradication using rodent models
2008 - 2010 Expression of transcription factors and epithelial-mesenchymal interaction in intestinal metaplasia of Helicobacter pylori-infected gastric mucosa
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Papers (64)：
Mizuho Uneyama, Takeshi Toyoda, Yuko Doi, Kohei Matsushita, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa. A 13-week subchronic toxicity study of linalool oxide in Crl:CD(SD) rats. Journal of toxicologic pathology. 2024. 37. 4. 151-161
Hirotoshi Akane, Takeshi Toyoda, Kohei Matsushita, Tomomi Morikawa, Tadashi Kosaka, Hitoshi Tajima, Hiroaki Aoyama, Kumiko Ogawa. Comparison of the sensitivity of histopathological and immunohistochemical analyses and blood hormone levels for early detection of antithyroid effects in rats treated with thyroid peroxidase inhibitors. Journal of applied toxicology : JAT. 2024
Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa. CD44 expression in renal tubular epithelial cells in the kidneys of rats with cyclosporine-induced chronic kidney disease. Journal of toxicologic pathology. 2024. 37. 2. 55-67
Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa. Role of CD44 expressed in renal tubules during maladaptive repair in renal fibrogenesis in an allopurinol-induced rat model of chronic kidney disease. Journal of applied toxicology : JAT. 2023
Jun-ichi Akagi, Young-Man Cho, Takeshi Toyoda, Yasuko Mizuta, Kumiko Ogawa. EpCAM and APN expression in combination with γ-H2AX as biomarkers for detecting hepatocarcinogens in rats. Cancer Science. 2023
松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子. Morphology and CD44 expression in renal tubules of rats with cyclosporine-induced renal fibrosis. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
豊田武士, 松下幸平, 赤根弘敏, 畝山瑞穂, 森川朋美, 小川久美子. Early detection of renal carcinogens by γ-H2AX immunostaining in rats. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
赤根弘敏, 豊田武士, 松下幸平, 畝山瑞穂, 森川朋美, 小坂忠司, 田島均, 青山博昭, 小川久美子. Pathological analysis and hormone levels in the detection of antithyroid effects of TSH synthesis inhibitors in rats. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
小林琢磨, 豊田武士, 吉岡泰淳, 渡邉正悟, 岸本真治, 松下幸平, 赤根弘敏, 小川久美子, 渡辺賢二, 高村岳樹, et al. Novel urinary metabolites of monocyclic aromatic amines induce ALDH1A1 expression in rat bladder epithelium. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
2024/04 - 現在 National Institute of Health Sciences Division of Pathology Head
2015/12 - 2024/03 Division of Pathology, National Institute of Health Sciences Section Chief
2011/04 - 2015/11 Division of Pathology, National Institute of Health Sciences Senior Researcher
2010/01 - 2011/03 Division of Pathology, National Institute of Health Sciences Researcher
2008/04 - 2009/12 Division of Oncological Pathology, Aichi Cancer Center Research Institute Researcher
2006/04 - 2008/03 Division of Oncological Pathology, Aichi Cancer Center Research Institute Research Resident
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Committee career (8)：
2024/04 - 現在 内閣府 食品安全委員会 専門参考人(農薬第三専門調査会)
2019/10 - 現在 内閣府 食品安全委員会 専門委員(新開発食品専門調査会)
2019/09 - 現在 独立行政法人 医薬品医療機器総合機構 専門委員
2019/01 - 現在 厚生労働省 薬事・食品衛生審議会 専門委員(化学物質調査会)
2017/09 - 現在 日本獣医病理学会 評議員
2017/04 - 現在 日本毒性病理学会 評議員
2020/04 - 2024/03 内閣府 食品安全委員会 専門委員(農薬第二専門調査会)
2016/04 - 2020/03 内閣府 食品安全委員会 専門委員(農薬専門調査会)
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Awards (2)：
2014/01 - Japanese Society of Toxicologic Pathology JTP Paper-of-the-Year Award (JTP Scientific Awards 2013) Detection of γ-H2AX, a biomarker for DNA double-strand breaks, in urinary bladders of N-butyl-N-(4-hydroxybutyl)-nitrosamine-treated rats
2012/02 - Japanese Society of Toxicologic Pathology JTP Incentive Award (JTP Scientific Awards 2011) Undifferentiated Sarcoma of the Salivary Gland in a Mongolian Gerbil (Meriones unguiculatus)
Association Membership(s) (6)：
The Japanese Society of Toxicology
, Japanese Association for Cancer Prevention
, Japanese Society of Toxicologic Pathology
, Japanese Society of Veterinary Pathology
, Japanese Cancer Association
, Japanese Society of Veterinary Science
