Takenobu Hisanori

タケノブヒサノリ | Takenobu Hisanori

Affiliation and department：
Job title： Researcher
Homepage URL (2)： https://www.pref.saitama.lg.jp/saitama-cc/kenkyujo/kenkyujo.html , http://www.pref.chiba.jp/byouin/gan/en/inst/index.html

Research field (3)： Pathobiochemistry , Developmental biology , Cell biology

Research keywords (8)：発生 , シグナル伝達 , 細胞分化 , 発癌 , Development , Signal transduction , Cell Differentiation , Development of Cancer

Research theme for competitive and other funds (12)：

2020 - 2023 神経芽腫発がんにおける網羅的遺伝子破壊を用いたセカンドヒット遺伝子領域の探索
2016 - 2018 難治性神経芽腫モデルマウスを用いた単細胞解析による創薬標的スクリーニング
2013 - 2015 A novel therapeutic targeting of CD133 transcription in malignant neuroblastoma
2010 - 2012 Identification of tumor stem-specific transcription factor in neuroblastoma sphere
2007 - 2009 Identification and functional analysis of novel stem cell markers in neuronal-related cells

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Papers (31)：

HIROTAKA FUCHIZAWA, KIYOHIRO ANDO, NORIKO MOTOI, TOSHIHIKO IIZUKA, MASAHARU INOUE, KOUKI MITANI, YUTA SANO, HISANORI TAKENOBU, MASAYUKI HARUTA, RITSUKO ONUKI, et al. STAT3 Contributes a Favorable Response to Pembrolizumab Through IFN-γ-induced Apoptosis in Urothelial Cancer. Anticancer Research. 2024. 44. 5. 1925-1930
Kiyohiro Ando, Ryo Kurashina, Noriko Motoi, Toshihiko Iizuka, Masaharu Inoue, Riko Maruyama, Kouki Mitani, Hisanori Takenobu, Masayuki Haruta, Ritsuko Onuki, et al. Positive regulatory loop of platelet-derived growth factor DD-induced STAT3 activation is associated with poor prognosis in advanced urothelial carcinoma. Biochemical and Biophysical Research Communications. 2023. 676. 165-170
Sultana Parvin, Jesmin Akter, Hisanori Takenobu, Yutaka Katai, Shunpei Satoh, Ryu Okada, Masayuki Haruta, Kyosuke Mukae, Tomoko Wada, Miki Ohira, et al. ATM depletion induces proteasomal degradation of FANCD2 and sensitizes neuroblastoma cells to PARP inhibitors. BMC Cancer. 2023. 23. 1
RYO KURASHINA, KIYOHIRO ANDO, MASAHARU INOUE, RIKO MARUYAMA, KOUKI MITANI, HISANORI TAKENOBU, MASAYUKI HARUTA, RITSUKO ONUKI, YOH MATSUOKA, TAKEHIKO KAMIJO, et al. Pretreatment Hemoglobin Levels and Platelet-to-Lymphocyte Ratio Predict Survival Benefit from Pembrolizumab in Advanced Urothelial Carcinoma. Cancer Diagnosis & Prognosis. 2023. 3. 2. 230-235
Kyosuke Mukae, Hisanori Takenobu, Yuki Endo, Masayuki Haruta, Tianyuan Shi, Shunpei Satoh, Miki Ohira, Michinori Funato, Junya Toguchida, Kenji Osafune, et al. Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell-derived neural crest cells. Cancer science. 2023

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MISC (26)：

遠藤悠紀, 竹信尚典, 仁尾正記, 上條岳彦. 神経芽腫におけるEZH2特異的阻害剤の感受性を制御する分子の探索. 日本小児外科学会雑誌. 2020. 56. 5. 629-629
竹信尚典, 大平美紀, 杉野隆一, サルマンディルバー, サルマンディルバー, 力石浩志, 力石浩志, 岡田龍, 岡田龍, 迎恭輔, et al. Tumor sphere specific gene CDX1 binds to OCT4 and MAX promoters to regulates stemness. 日本癌学会学術総会抄録集(Web). 2020. 79th
迎恭輔, 竹信尚典, 杉野隆一, 大平美紀, 佐藤俊平, 遠藤悠紀, 岡田龍, 春田雅之, 戸口田淳也, 長船健二, et al. iPS細胞由来神経堤細胞の神経芽腫発生メカニズム解析のための細胞モデル開発(Development of neuroblastoma model from iPS-based neural crest cells for analysis of neuroblastoma tumorigenesis). 日本癌学会総会記事. 2018. 77回. 1278-1278
遠藤悠紀, 竹信尚典, 杉野隆一, 春田雅之, 迎恭輔, 佐藤俊平, 秦佳孝, 長谷川真理子, 岡田龍, 片井友貴, et al. 神経芽腫におけるEZH2阻害剤の感受性を制御する分子の探索(Identification of molecules that regulate the sensitivity of EZH2 inhibitor in neuroblastoma). 日本癌学会総会記事. 2018. 77回. 1965-1965
Hisanori Takenobu, Ryuichi Sugino, Miki Ohira, Koji Chikaraishi, Kyosuke Mukae, Yuki Endo, Sultana Parvin, Ryu Okada, Yutaka Katai, Masayuki Haruta, et al. Sphere Specific Transcription Factor CDX1 Regulates Stemness of Neuroblastoma. PEDIATRIC BLOOD & CANCER. 2017. 64. S46-S46

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Education (4)：

- 2003 Osaka University
- 2003 Osaka University Graduate School, Division of Natural Science Biology
Okayama University Faculty of Agriculture Department of Agricultural Sciences
Okayama University Faculty of Agriculture Agricaltural Science

Professional career (2)：

Doctor(Science) (Osaka University)
Master(Science) (Osaka University)

Work history (7)：

2015/01 - 現在 Research Institute for Clinical Oncology, Saitama Cancer Center Researcher
2004 - 2014 - 千葉県がんセンター研究員
2003 - 2004 大阪大学微生物研究所研究員
2003 - 2004 Researcher, Research Institute for Microbial
2004 - - Research Fellow, Chiba Cancer Center Research

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Association Membership(s) (4)：

日本小児がん学会 , 日本癌学会 , Japanese Society of Pediatric Oncology , Japan Cancer Association

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