Rchr
J-GLOBAL ID：200901069810594150   Update date: Sep. 28, 2024

Takenobu Hisanori

タケノブ ヒサノリ | Takenobu Hisanori
Affiliation and department：
Saitama Cancer Center,Research Institute For Clinical Oncology

About Saitama Cancer Center,Research Institute For Clinical Oncology


Job title： Researcher
Homepage URL  (2)： https://www.pref.saitama.lg.jp/saitama-cc/kenkyujo/kenkyujo.html ,  http://www.pref.chiba.jp/byouin/gan/en/inst/index.html
Research field  (3)： Pathobiochemistry ,  Developmental biology ,  Cell biology
Research keywords  (8)： 発生 ,  シグナル伝達 ,  細胞分化 ,  発癌 ,  Development ,  Signal transduction ,  Cell Differentiation ,  Development of Cancer
Research theme for competitive and other funds  (12)：
  • 2020 - 2023 神経芽腫発がんにおける網羅的遺伝子破壊を用いたセカンドヒット遺伝子領域の探索
  • 2016 - 2018 難治性神経芽腫モデルマウスを用いた単細胞解析による創薬標的スクリーニング
  • 2013 - 2015 A novel therapeutic targeting of CD133 transcription in malignant neuroblastoma
  • 2010 - 2012 Identification of tumor stem-specific transcription factor in neuroblastoma sphere
  • 2007 - 2009 Identification and functional analysis of novel stem cell markers in neuronal-related cells
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Papers (38)：
  • Ryu Okada, Hisanori Takenobu, Shunpei Satoh, Ryuichi P. Sugino, Ritsuko Onuki, Masayuki Haruta, Kyosuke Mukae, Atsuko Nakazawa, Jesmin Akter, Miki Ohira, et al. L3MBTL2 maintains MYCN-amplified neuroblastoma cell proliferation through silencing NRIP3 and BRME1 genes. Genes to Cells. 2024
  • HIROTAKA FUCHIZAWA, KIYOHIRO ANDO, NORIKO MOTOI, TOSHIHIKO IIZUKA, MASAHARU INOUE, KOUKI MITANI, YUTA SANO, HISANORI TAKENOBU, MASAYUKI HARUTA, RITSUKO ONUKI, et al. STAT3 Contributes a Favorable Response to Pembrolizumab Through IFN-γ-induced Apoptosis in Urothelial Cancer. Anticancer Research. 2024. 44. 5. 1925-1930
  • Kiyohiro Ando, Ryo Kurashina, Noriko Motoi, Toshihiko Iizuka, Masaharu Inoue, Riko Maruyama, Kouki Mitani, Hisanori Takenobu, Masayuki Haruta, Ritsuko Onuki, et al. Positive regulatory loop of platelet-derived growth factor DD-induced STAT3 activation is associated with poor prognosis in advanced urothelial carcinoma. Biochemical and Biophysical Research Communications. 2023. 676. 165-170
  • 竹信 尚典, サルマン・ディルバー, 大平 美紀, 杉野 隆一, 遠藤 悠紀, 上條 岳彦. PRC2構成分子EEDは神経芽腫のエピジェネティックな標的となりうる(The PRC2 molecule EED is a target of epigenetic therapy for neuroblastoma). 日本癌学会総会記事. 2023. 82回. 221-221
  • Sultana Parvin, Jesmin Akter, Hisanori Takenobu, Yutaka Katai, Shunpei Satoh, Ryu Okada, Masayuki Haruta, Kyosuke Mukae, Tomoko Wada, Miki Ohira, et al. ATM depletion induces proteasomal degradation of FANCD2 and sensitizes neuroblastoma cells to PARP inhibitors. BMC Cancer. 2023. 23. 1
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MISC (26)：
  • 遠藤 悠紀, 竹信 尚典, 仁尾 正記, 上條 岳彦. 神経芽腫におけるEZH2特異的阻害剤の感受性を制御する分子の探索. 日本小児外科学会雑誌. 2020. 56. 5. 629-629
  • 竹信尚典, 大平美紀, 杉野隆一, サルマン ディルバー, サルマン ディルバー, 力石浩志, 力石浩志, 岡田龍, 岡田龍, 迎恭輔, et al. Tumor sphere specific gene CDX1 binds to OCT4 and MAX promoters to regulates stemness. 日本癌学会学術総会抄録集(Web). 2020. 79th
  • 迎 恭輔, 竹信 尚典, 杉野 隆一, 大平 美紀, 佐藤 俊平, 遠藤 悠紀, 岡田 龍, 春田 雅之, 戸口田 淳也, 長船 健二, et al. iPS細胞由来神経堤細胞の神経芽腫発生メカニズム解析のための細胞モデル開発(Development of neuroblastoma model from iPS-based neural crest cells for analysis of neuroblastoma tumorigenesis). 日本癌学会総会記事. 2018. 77回. 1278-1278
  • 遠藤 悠紀, 竹信 尚典, 杉野 隆一, 春田 雅之, 迎 恭輔, 佐藤 俊平, 秦 佳孝, 長谷川 真理子, 岡田 龍, 片井 友貴, et al. 神経芽腫におけるEZH2阻害剤の感受性を制御する分子の探索(Identification of molecules that regulate the sensitivity of EZH2 inhibitor in neuroblastoma). 日本癌学会総会記事. 2018. 77回. 1965-1965
  • Hisanori Takenobu, Ryuichi Sugino, Miki Ohira, Koji Chikaraishi, Kyosuke Mukae, Yuki Endo, Sultana Parvin, Ryu Okada, Yutaka Katai, Masayuki Haruta, et al. Sphere Specific Transcription Factor CDX1 Regulates Stemness of Neuroblastoma. PEDIATRIC BLOOD & CANCER. 2017. 64. S46-S46
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Education (4)：
  • - 2003 Osaka University
  • - 2003 Osaka University Graduate School, Division of Natural Science Biology
  • Okayama University Faculty of Agriculture Department of Agricultural Sciences
  • Okayama University Faculty of Agriculture Agricaltural Science
Professional career (2)：
  • Doctor(Science) (Osaka University)
  • Master(Science) (Osaka University)
Work history (7)：
  • 2015/01 - 現在 Research Institute for Clinical Oncology, Saitama Cancer Center Researcher
  • 2004 - 2014 - 千葉県がんセンター 研究員
  • 2003 - 2004 大阪大学微生物研究所 研究員
  • 2003 - 2004 Researcher, Research Institute for Microbial
  • 2004 - - Research Fellow, Chiba Cancer Center Research
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Association Membership(s) (4)：
日本小児がん学会 ,  日本癌学会 ,  Japanese Society of Pediatric Oncology ,  Japan Cancer Association
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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