Murayama Takashi

ムラヤマタカシ | Murayama Takashi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://pharmacology.sakura.ne.jp/jp/staff.html#murayama

Research field (3)： Clinical pharmacy , Physiology , Pharmacology

Research keywords (2)：薬理学 , Pharmacology

Research theme for competitive and other funds (23)：

2022 - 2025 筋肉熱シグナリング破綻・暴走の個体解析
2022 - 2025 Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
2021 - 2024 Structural analysis of the gating mechanism of cardiac ryanodine receptor
2021 - 2024 The construction of exercise therapy in familial DCM model mice
2019 - 2022 新規リアノジン受容体作用薬を利用したサブタイプ特異的チャネル制御の分子機構

2019 - 2022 Effectiveness of RyR2 inhibitors as antiarrhytmic drugs

2019 - 2022 生理実験と分子動力学計算を組み合わせた新規リアノジン受容体制御機構の解析

2017 - 2020 Regulation of TRPM7 channel activity in the lipid bilayers

2016 - 2020 Elucidation of ryanodine receptor channel gating mechanism at atomic level

2015 - 2019 Establishment of analysis method of ryanodine receptor arrhythmogenic mutations and its application to therapeutic drug screening

2015 - 2019 The construction of exercise therapy on DCM model mice

2012 - 2015 Elucidation of regulatory mechanisms of type 2 ryanodine receptors by introducing artificial amino acids

2012 - 2015 Exploration of anti-arrhythmic drugs acting on RyR2 using myocardium and cultured cells.

2011 - 2015 Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment

2009 - 2011 Regulation of ryanodine receptor channel by interdomain interaction

2007 - 2008 Role of calcium homeostasis in Schwartz-Jampel syndrome

2006 - 2007 An experimental study for the mechanism of atrial fibrillation and its control by means of optical imaging of cell-to-cell communication

2005 - 2007 Molecular mechanisms underlying abnormal functions in RyR2 complex in cardiac hypertrophy/heart failure

2005 - 2006 ヘパラン硫酸プロテオグリカン、パールカンによる筋収縮シグナル制御の研究

2000 - 2001 DO CYSTEINES LOCATED NEAR THE CHANNEL PORE OF THE RYANODINE RECEPTOR FUNCTION AS TARGET AMINO ACID FOR REACTIVE OXYGEN SPECIES?

1998 - 1999 哺乳類における容量性Ca^<2+>流入機構の解明

1998 - 1998 蛍光プローブによるCa^<2+>放出チャネルタンパク質の機能分担の解明

1996 - 1996 血管平滑筋におけるリアノジン受容体アイソフォームの役割の検討

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Papers (120)：

Yuta Okabe, Nobuyuki Murakoshi, Nagomi Kurebayashi, Hana Inoue, Yoko Ito, Takashi Murayama, Chika Miyoshi, Hiromasa Funato, Koichiro Ishii, Dongzhu Xu, et al. An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 17. e2218204121
Mai Takenaka, Masami Kodama, Takashi Murayama, Mari Ishigami-Yuasa, Shuichi Mori, Ryosuke Ishida, Junji Suzuki, Kazunori Kanemaru, Masami Sugihara, Masamitsu Iino, et al. Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring. Molecular pharmacology. 2023. 104. 6. 275-286
Jianshu Hu, Elisa Venturi, Charalampos Sigalas, Takashi Murayama, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan. The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2. Journal of General Physiology. 2023
Ryosuke Ishida, Nagomi Kurebayashi, Hiroto Iinuma, Xi Zeng, Shuichi Mori, Masami Kodama, Takashi Murayama, Hiroyuki Masuno, Fumi Takeda, Masatoshi Kawahata, et al. A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. European journal of medicinal chemistry. 2023. 262. 115910-115910
Takashi Murayama, Nagomi Kurebayashi, Ryosuke Ishida, Hiroyuki Kagechika. Drug development for the treatment of RyR1-related skeletal muscle diseases. Current opinion in pharmacology. 2023. 69. 102356-102356

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MISC (169)：

野中美希, 上野晋, 柿木亮, 岸田昭世, 呉林なごみ, 村山尚, 櫻井隆, 上園保仁. 回し車を用いた自発運動負荷によるがん悪液質性心機能障害に対する治療効果の検討. 日本腫瘍循環器学会学術集会抄録集(Web). 2021. 4th
Takashi Murayama, Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Satoru Noguchi, Ichizo Nishino, Shuichi Mori, Hiroyuki Kagechika, Jose R. Lopez, Paul D. Allen. Therapeutic Effects of a Novel RyR1 Inhibitor on Malignant Hyperthermia-Susceptible Model Mice. BIOPHYSICAL JOURNAL. 2020. 118. 3. 98A-98A
Nonaka Miki, Ueno Susumu, Kakigi Ryo, Kurebayashi Nagomi, Murayama Takashi, Miyano Kanako, Terawaki Kiyoshi, Sakurai Takashi, Uezono Yasuhito. Voluntary wheel running improves cardiac dysfunction associated with cancer cachexia induced by human stomach cancer cell line 85As2. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 3-O-128
Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi. Sexual differences on effects of voluntary exercise on heart failure in DCM model mice. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 2-P-207
伊藤英樹, 村山尚, 呉林なごみ, 大野聖子, 藤居祐介, 加藤浩一, 福山恵, 高山幸一郎, 渡邉昌也, 安斉俊久, et al. Excessive Ca2+ Release from Ryanodine Receptors Underlying a RyR2 Mutation Associated with Catecholaminergic Polymorphic Ventricular Tachycardia(和訳中). 日本循環器学会学術集会抄録集. 2019. 83回. OJ05-4

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Patents (1)：

Ca2+誘発性Ca2+遊離活性抑制剤のスクリーニング方法

Books (2)：

Ryanodine Receptor(共著)
続心臓代謝実験法 1998
Further characterozation of ryanodine receptor isoforms purified from bullfrog skeletal muscle(共著)
Calcium as Cell Signal (K.Maruyama,Y.Nonomura,and K.Kohama eds.),lgaku Shoin Ltd.,Tokyo 1995

Education (4)：

1988 - 1990 千葉大学大学院理学研究科生物学専攻
- 1990 Chiba University Graduate School, Division of Natural Science
1984 - 1988 Chiba University Faculty of Science Department of Biology
- 1988 Chiba University Faculty of Science

Professional career (2)：

Doctor of Philosophy (Juntendo University)
Master of Biology (Chiba University)

Work history (4)：

2022/02 - 現在 Juntendo University Faculty of Medicine
2007/04 - 2022/01 Juntendo University Faculty of Medicine
1997/04 - 2007/03 Juntendo University Faculty of Medicine
1990/04 - 1997/03 Juntendo University Faculty of Medicine

Association Membership(s) (11)：

JAPANESE SOCIETY OF ANESTHESIOLOGISTS , 日本生理学会 , American Physiological Society , Biophysical Society , 日本薬理学会 , American Physiological Society , Biophysical Society , The Biophysical Society of Japan , Physiological Society of Japan , The Japanese Biochemical Society , The Japanese Pharmacological Society

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