Research field (3)：
Clinical pharmacy
, Physiology
, Pharmacology
Research keywords (2)：
薬理学
, Pharmacology
Research theme for competitive and other funds (26)：
2024 - 2027 創薬へ向けた心筋型リアノジン受容体の活性制御機構の構造的解明
2024 - 2025 Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
2023 - 2025 新規モデル動物を用いた骨格筋におけるリアノジン受容体CICR機構の意義
2022 - 2025 筋肉熱シグナリング破綻・暴走の個体解析
2022 - 2025 Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
2021 - 2024 Structural analysis of the gating mechanism of cardiac ryanodine receptor
2021 - 2024 The construction of exercise therapy in familial DCM model mice
2019 - 2022 新規リアノジン受容体作用薬を利用したサブタイプ特異的チャネル制御の分子機構
2019 - 2022 Effectiveness of RyR2 inhibitors as antiarrhytmic drugs
2019 - 2022 生理実験と分子動力学計算を組み合わせた新規リアノジン受容体制御機構の解析
2017 - 2020 Regulation of TRPM7 channel activity in the lipid bilayers
2016 - 2020 Elucidation of ryanodine receptor channel gating mechanism at atomic level
2015 - 2019 Establishment of analysis method of ryanodine receptor arrhythmogenic mutations and its application to therapeutic drug screening
2015 - 2019 The construction of exercise therapy on DCM model mice
2012 - 2015 Elucidation of regulatory mechanisms of type 2 ryanodine receptors by introducing artificial amino acids
2012 - 2015 Exploration of anti-arrhythmic drugs acting on RyR2 using myocardium and cultured cells.
2011 - 2015 Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment
2009 - 2011 Regulation of ryanodine receptor channel by interdomain interaction
2007 - 2008 Role of calcium homeostasis in Schwartz-Jampel syndrome
2006 - 2007 An experimental study for the mechanism of atrial fibrillation and its control by means of optical imaging of cell-to-cell communication
2005 - 2007 Molecular mechanisms underlying abnormal functions in RyR2 complex in cardiac hypertrophy/heart failure
2005 - 2006 ヘパラン硫酸プロテオグリカン、パールカンによる筋収縮シグナル制御の研究
2000 - 2001 DO CYSTEINES LOCATED NEAR THE CHANNEL PORE OF THE RYANODINE RECEPTOR FUNCTION AS TARGET AMINO ACID FOR REACTIVE OXYGEN SPECIES?
1998 - 1999 哺乳類における容量性Ca^<2+>流入機構の解明
1998 - 1998 蛍光プローブによるCa^<2+>放出チャネルタンパク質の機能分担の解明
1996 - 1996 血管平滑筋におけるリアノジン受容体アイソフォームの役割の検討
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Papers (117)：
Takashi Murayama, Yuya Otori, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Takashi Sakurai, Haruo Ogawa. Dual role of the S5 segment in type 1 ryanodine receptor channel gating. Communications Biology. 2024. 7. 1
Yuta Okabe, Nobuyuki Murakoshi, Nagomi Kurebayashi, Hana Inoue, Yoko Ito, Takashi Murayama, Chika Miyoshi, Hiromasa Funato, Koichiro Ishii, Dongzhu Xu, et al. An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 17. e2218204121
Atsushi Hori, Haruka Inaba, Takashi Hato, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe, Shusuke Mori, et al. Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease. PloS one. 2024. 19. 8. e0291887
Ryosuke Ishida, Xi Zeng, Nagomi Kurebayashi, Takashi Murayama, Shuichi Mori, Hiroyuki Kagechika. Discovery and Structure-Activity Relationship of a Ryanodine Receptor 2 Inhibitor. Chemical & pharmaceutical bulletin. 2024. 72. 4. 399-407
Mai Takenaka, Masami Kodama, Takashi Murayama, Mari Ishigami-Yuasa, Shuichi Mori, Ryosuke Ishida, Junji Suzuki, Kazunori Kanemaru, Masami Sugihara, Masamitsu Iino, et al. Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring. Molecular pharmacology. 2023. 104. 6. 275-286
大鳥祐矢, BURTON-SMITH Raymond, 呉林なごみ, 村田和義, 加藤博章, 加藤博章, 村山尚, 小川治夫. Structural basis for the effect of caffeine on RyR2 analyzed by cryo-EM. 日本生体エネルギー研究会討論会講演要旨集. 2023. 49th
Takashi Murayama, Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Satoru Noguchi, Ichizo Nishino, Shuichi Mori, Hiroyuki Kagechika, Jose R. Lopez, Paul D. Allen. Therapeutic Effects of a Novel RyR1 Inhibitor on Malignant Hyperthermia-Susceptible Model Mice. BIOPHYSICAL JOURNAL. 2020. 118. 3. 98A-98A
Further characterozation of ryanodine receptor isoforms purified from bullfrog skeletal muscle(共著)
Calcium as Cell Signal (K.Maruyama,Y.Nonomura,and K.Kohama eds.),lgaku Shoin Ltd.,Tokyo 1995
Education (4)：
1988 - 1990 千葉大学大学院 理学研究科 生物学専攻
- 1990 Chiba University Graduate School, Division of Natural Science
1984 - 1988 Chiba University Faculty of Science Department of Biology
- 1988 Chiba University Faculty of Science
Professional career (2)：
Doctor of Philosophy (Juntendo University)
Master of Biology (Chiba University)
Work history (4)：
2022/02 - 現在 Juntendo University Faculty of Medicine
2007/04 - 2022/01 Juntendo University Faculty of Medicine
1997/04 - 2007/03 Juntendo University Faculty of Medicine
1990/04 - 1997/03 Juntendo University Faculty of Medicine
Association Membership(s) (11)：
JAPANESE SOCIETY OF ANESTHESIOLOGISTS
, 日本生理学会
, American Physiological Society
, Biophysical Society
, 日本薬理学会
, American Physiological Society
, Biophysical Society
, The Biophysical Society of Japan
, Physiological Society of Japan
, The Japanese Biochemical Society
, The Japanese Pharmacological Society
