Akizawa Toshifumi

アキザワトシフミ | Akizawa Toshifumi

Affiliation and department：

Research field (6)： Cognitive neuroscience , Animals: biochemistry, physiology, behavioral science , Pharmacology , Pharmaceuticals - health and biochemistry , Pharmaceuticals - chemistry and drug development , Molecular biochemistry

Research keywords (8)：神経変性疾患 , 凝集性タンパク質 , プリオン病 , Parkinson's disease , Alzheimer's disease , Catalytic peptide , 癌転移 , Cancer Invasion

Research theme for competitive and other funds (11)：

2019 - 2022 Creation of novel Catalytide with In Silico
2015 - 2018 Physical and chemical analyses of aggregation mechanism by using Prion fragment peptides
2012 - 2015 Analysis of prion protein aggregation mechanism by using that fragment peptides
癌の転移予防薬の開発
マトリックスメタロプロテアーゼ阻害剤の検索

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Papers (38)：

Rina Nakamura, Motomi Konishi, Youichirou Higashi, Motoaki Saito, Toshifumi Akizawa. Five-mer peptides prevent short-term spatial memory deficits in Aβ25-35-induced Alzheimer's model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form. Alzheimer's research & therapy. 2023. 15. 1. 83-83
Rina Nakamura, Toshifumi Akizawa, Motomi Konishi. Structure-Activity Relationship of 5-mer Catalytides, GSGYR and RYGSG. Biomolecules. 2022. 12. 12. 1766-1766
Aratake Takaaki, Higashi Youichirou, Shimizu Takahiro, Shimizu Shogo, Zou Suo, Nakamura Rina, Akizawa Toshifumi, Saito Motoaki. Ischemia-induced Zn²⁺ accumulation is modulated by EAAT3 diurnal fluctuation in the hippocampus. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 3-P-192
Yusuke Hatakawa, Akiko Tanaka, Tomoyuki Furubayashi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sakane. Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration. Pharmaceutics. 2021. 13. 10. 1673-1673
Higashi Youichirou, Aratake Takaaki, Hamada Tomoya, Shimizu Takahiro, Shimizu Shogo, Zou Suo, Yamamoto Masaki, Nakamura Rina, Akizawa Toshifumi, Saito Motoaki. Zinc-aggravated M1 microglia suppress astrocytic engulfing activity via P2X7 receptors. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 1-P1-17

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MISC (252)：

中村里菜, 中村里菜, 小西元美, 齊藤源顕, 秋澤俊史, 秋澤俊史. Identification of the Seeds Peptides for the Drug of Parkinson’s Disease. バイオメディカル分析科学シンポジウム講演要旨集. 2022. 34th
秋澤俊史, 中村里菜. Development of New Strategic Drug for Neurogenric Diseases. バイオメディカル分析科学シンポジウム講演要旨集. 2022. 34th
岡田百加, 中村里菜, 中村里菜, 齊藤源顕, 秋澤俊史, 秋澤俊史. Effects of Catalytic Peptide, JAL-TA9, Against Cell Toxicity Induced by Aβ25-35. JSBMS Letters. 2022. 47. Supplement
中村里菜, 中村里菜, 小西元美, 林芳弘, 齊藤源顕, 秋澤俊史, 秋澤俊史. Hydrolase Activity of JAL-TA9 Against Deposited Amyloid-β42 in Human Brain Slice. JSBMS Letters. 2022. 47. Supplement
新武享朗, 新武享朗, 東洋一郎, 清水孝洋, 清水翔吾, SUO Zou, 中村里菜, 秋澤俊史, 齊藤源顕. 海馬における一過性脳虚血後Zn²⁺毒性はEAAT3日内変動により制御される. 日本薬理学雑誌. 2022. 157. Supplement

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Patents (5)：

Books (2)：

分析化学
朝倉書店 2018 ISBN:9784254362763
薬剤師に必要な臨床機器分析
廣川書店 2010 ISBN:9784567256407

Works (2)：

マトリックスメタロプロテアーザ阻害剤の検索
1997 -
Mauscreaning for MMP Inhibitors
1997 -

Education (4)：

- 1986 Tokyo Medical and Dental University
- 1986 Tokyo Medical and Dental University Graduate School, Division of Medicine
- 1980 Hiroshima University Faculty of Medicine
- 1980 Hiroshima University Faculty of Medicine

Professional career (2)：

(BLANK) (Tokyo Medical and Dental University)
(BLANK) (Hiroshima University)

Work history (7)：

2020/04 - 現在 Kochi University Medical School
2018/04 - 2020/03 Kochi University Medical School
1989 - 1990 新技術事業団古沢発生遺伝子プロジェクト
1988 - 1990 (財)癌研究会癌研究所ウィルス腫瘍部
1990 - - 摂南大学薬学部

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Association Membership(s) (3)：

病態プロテアーゼ学会 , 日本分析化学会 , 日本薬学会

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