Akizawa Toshifumi

アキザワトシフミ | Akizawa Toshifumi

Affiliation and department：

Research field (6)： Cognitive neuroscience , Animals: biochemistry, physiology, behavioral science , Pharmacology , Pharmaceuticals - health and biochemistry , Pharmaceuticals - chemistry and drug development , Molecular biochemistry

Research keywords (8)：神経変性疾患 , 凝集性タンパク質 , プリオン病 , Parkinson's disease , Alzheimer's disease , Catalytic peptide , 癌転移 , Cancer Invasion

Research theme for competitive and other funds (11)：

2019 - 2022 Creation of novel Catalytide with In Silico
2015 - 2018 Physical and chemical analyses of aggregation mechanism by using Prion fragment peptides
2012 - 2015 Analysis of prion protein aggregation mechanism by using that fragment peptides
癌の転移予防薬の開発
マトリックスメタロプロテアーゼ阻害剤の検索

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Papers (42)：

Yusuke Hatakawa, Rina Nakamura, Toshifumi Akizawa, Motomi Konishi, Akira Matsuda, Tomoyuki Oe, Motoaki Saito, Fumiaki Ito. SKGQA, a Peptide Derived from the ANA/BTG3 Protein, Cleaves Amyloid-β with Proteolytic Activity. Biomolecules. 2024. 14. 5
Rina Nakamura, Motomi Konishi, Youichirou Higashi, Motoaki Saito, Toshifumi Akizawa. Five-mer peptides prevent short-term spatial memory deficits in Aβ25-35-induced Alzheimer's model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form. Alzheimer's research & therapy. 2023. 15. 1. 83-83
Zou Suo, Nakamura Rina, Higashi Youichirou, Hayashi Yoshihiro, Konishi Motomi, Ito Fumiaki, Saito Motoaki, Akizawa Toshifumi. Effects of JAL-TA9 on cognitive deficits in Alzheimer’s disease model mouse. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023. 97. 1-B-S19-2
Rina Nakamura, Toshifumi Akizawa, Motomi Konishi. Structure-Activity Relationship of 5-mer Catalytides, GSGYR and RYGSG. Biomolecules. 2022. 12. 12. 1766-1766
Aratake Takaaki, Higashi Youichirou, Shimizu Takahiro, Shimizu Shogo, Zou Suo, Nakamura Rina, Akizawa Toshifumi, Saito Motoaki. Ischemia-induced Zn²⁺ accumulation is modulated by EAAT3 diurnal fluctuation in the hippocampus. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 3-P-192

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MISC (259)：

中村里菜, 中村里菜, 小西元美, 東洋一郎, 齊藤源顕, 秋澤俊史, 秋澤俊史. Identification of Suppressing Aβ25-35 Aggregation and Resolving its Aggregate Form Peptides for the Development of Drug for Alzheimer’s Disease. バイオメディカル分析科学シンポジウム講演要旨集. 2023. 35th
小西元美, 中村里奈, 中村里奈, 秋澤俊史, 秋澤俊史. Structural analysis of the peptide GSGFK that inhibits amyloid β25-35 aggregation. 日本薬学会年会要旨集(Web). 2023. 143rd
中村里菜, 中村里菜, 幡川祐資, 坂根稔康, 小西元美, 齊藤源顕, 秋澤俊史, 秋澤俊史. アルツハイマー病治療薬としての臨床試験を目指したCatalytideの投与方法の検討. 日本薬理学雑誌. 2023. 158. Supplement
中村里菜, 中村里菜, 岡田百加, 小西元美, 東洋一郎, 齊藤源顕, 秋澤俊史, 秋澤俊史. Aβ25-35による神経細胞死に対する酵素ペプチドの作用. 日本アミロイドーシス学会学術集会プログラム・抄録集. 2023. 10th
谷口大樹, 中村里菜, 中村里菜, 坂田大輔, 小西元美, 東洋一郎, 齊藤源顕, 秋澤俊史, 秋澤俊史. Tauを分解する酵素ペプチド(Catalytide)の同定. 日本アミロイドーシス学会学術集会プログラム・抄録集. 2023. 10th

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Patents (5)：

Books (2)：

分析化学
朝倉書店 2018 ISBN:9784254362763
薬剤師に必要な臨床機器分析
廣川書店 2010 ISBN:9784567256407

Works (2)：

マトリックスメタロプロテアーザ阻害剤の検索
1997 -
Mauscreaning for MMP Inhibitors
1997 -

Education (4)：

- 1986 Tokyo Medical and Dental University
- 1986 Tokyo Medical and Dental University Graduate School, Division of Medicine
- 1980 Hiroshima University Faculty of Medicine
- 1980 Hiroshima University Faculty of Medicine

Professional career (2)：

(BLANK) (Tokyo Medical and Dental University)
(BLANK) (Hiroshima University)

Work history (7)：

2020/04 - 現在 Kochi University Medical School
2018/04 - 2020/03 Kochi University Medical School
1989 - 1990 新技術事業団古沢発生遺伝子プロジェクト
1988 - 1990 (財)癌研究会癌研究所ウィルス腫瘍部
1990 - - 摂南大学薬学部

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Association Membership(s) (3)：

病態プロテアーゼ学会 , 日本分析化学会 , 日本薬学会

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