Yawata Toshio

ヤワタトシオ | Yawata Toshio

Affiliation and department：
Job title： Assistant Professor

Research field (3)： Neurosurgery , Medical biochemistry , Molecular biology

Research keywords (2)：腫瘍生物学 , Cancer Biology

Research theme for competitive and other funds (24)：

2022 - 2025 亜鉛によるミクログリア制御機構を応用した脳卒中リハビリテーション促進薬の開発
2022 - 2025 免疫細胞の加齢による腫瘍微小環境の変化とその制御による膠芽腫治療法の開発
2022 - 2025 Development of new therapies based on immunological analysis of WT1 vaccine therapy for glioma stem cells
2020 - 2023 性差関連因子の解析による膠芽腫の発生や治療抵抗性に関わる新たな経路の同定
2020 - 2023 siRNA結合ナノパーティクルを用いた膠芽腫に対する標的遺伝子治療法の開発

2019 - 2022 Development of preventive method for stroke sequelae targeting zinc-mediated glial interaction

2018 - 2021 Development of targeted therapy for glioblastoma by suppression of mesenchymal property

2017 - 2020 Regulatory system of RNA methylation in malignant brain tumors

2017 - 2020 Development of RNA Interference targeting messenger RNAs involved in the invasiveness and metastasis of pancreatic cancer cells

2015 - 2018 The role of chelatable zinc in microglial activation

2014 - 2018 Assessment of IFN-alpha activated BID gene/radiation combined modality therapy for human cancer stem cells

2015 - 2017 Development of mouse brain tumor models by epigenetic disturbance of imprinting genes

2014 - 2017 Functional analysis of Methyl-CpG-binding domain protein 1 in differentiation process of malignant brain tumor

2014 - 2017 Basic research for exploitation of novel central antihypertensive drugs focusing on regulation of responses to stress

2013 - 2016 悪性脳腫瘍におけるゲノムグローバルなヒストン修飾制御因子の探索

2012 - 2015 Determination of stress sensitivity molecules that exacerbate depression after head injury

2010 - 2013 エピジェネティック因子の再構築による脳腫瘍ゲノムの機能的解析

2011 - 2012 Effect of abnormalities in asymmetric cell divisions of neural stem cells on brain tumor initiation

2011 - 2011 グリオーマ腫瘍幹細胞の浸潤能に関与するMUC18遺伝子を標的とした新規治療の開発

2007 - 2009 がん幹細胞の生み出す多様性の原因解析と免疫療法への応用

2007 - 2008 Preliminary study of the induction of malignant glioma apoptosis using mesenchymal stem cell-mediated delivery of TRAIL and IL12

2004 - 2007 Development of retroviral vectors for gene therapy

2004 - 2006 New therapeutic strategies for malignant brain tumors by using genetic and molecular biology

2005 - 2005 ES細胞と成熟脳細胞との細胞融合による神経再プログラム化と再生医療への基礎的検討

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Papers (34)：

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MISC (22)：

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Patents (1)：

Books (3)：

Education (5)：

Professional career (1)：

Work history (14)：

2000 - 2004 National Cancer Institute (NCI/NIH) Laboratory of Biosystems and Cancer
2000 - 2004 Visiting Fellow, National Cancer Institute,
2004 - Kochi Medical School Department of Neurosurgery
2004 - - Assistant Professor, faculty of medicine,
1999 - 2000 National Institute of Environmental Health Sciences (NIEHS/NIH) Laboratory of Molecular Carcinogenesis

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Association Membership(s) (6)：

日本再生医療学会 , 分子脳神経外科学会 , 日本遺伝子治療学会 , 日本脳腫瘍学会 , 日本癌学会 , American Association for Cancer Research

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