Nishimura Kazuhiro

ニシムラカズヒロ | Nishimura Kazuhiro

Affiliation and department：
Job title： Proffessor

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (6)： eIF5A , Cell proliferation and differentiation , Gene expression , Hypusine , Translation , Polyamines

Research theme for competitive and other funds (10)：

2020 - 2023 The mechanism of polyamine stimulation of purine nucleotide biosynthesis
2015 - 2018 Study of translational regulation mediated gene expression relating cell proliferation and differentiation by polyamines
2015 - 2017 Investigation of RNA aptamer for polyamine and its application
2011 - 2015 Elucidation of molecular mechanism of cellular toxicity of acrolein and its clinical application
2010 - 2011 Study of translational regulation for cell proliferation by polyamines

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Papers (49)：

Kazuhiro Nishimura, Sakamuri V. Reddy, Moemi Okamoto, Rina Shibue, Toshio Mizuta, Toru Shibayama, Tetsuhiko Yoshino, Teruki Murakami, Masashi Yamaguchi, Satoshi Tanaka, et al. KLF4 is required for suppression of histamine synthesis by polyamines during bone marrow-derived mast cell differentiation. PLOS ONE. 2020. 15. 2
Reiya Ohta, Akihiro Oguro, Kazuhiro Nishimura, Kenichi Murai, Hiromichi Fujioka, Mitsuhiro Arisawa. Design and synthesis of: N ¹ , N ⁸ -diacetylspermidine analogues having a linker with desired functional groups. Organic and Biomolecular Chemistry. 2019. 17. 4. 867-875
Takuya Kumamoto, Marie Nakajima, Reina Uga, Naoko Ihayazaka, Haruna Kashihara, Kazuaki Katakawa, Tsutomu Ishikawa, Ryotaro Saiki, Kazuhiro Nishimura, Kazuei Igarashi. Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers. Bioorganic and Medicinal Chemistry. 2018. 26. 3. 603-608
Asher Williams, Wenqin He, Brady F. Cress, Xinyue Liu, Jordanne Alexandria, Hiroki Yoshizawa, Kazuhiro Nishimura, Toshihiko Toida, Mattheos Koffas, Robert J. Linhardt. Cloning and Expression of Recombinant Chondroitinase ACII and Its Comparison to the Arthrobacter aurescens Enzyme. BIOTECHNOLOGY JOURNAL. 2017. 12. 10
Masataka Imamura, Kyohei Higashi, Katsutoshi Yamaguchi, Kiryu Asakura, Tomomi Furihata, Yusuke Terui, Toshihiko Satake, Jiro Maegawa, Kazunori Yasumura, Ai Ibuki, et al. Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2. SCIENTIFIC REPORTS. 2016. 6

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MISC (17)：

今村正隆, 東恭平, 山口勝利, 朝倉希里生, 降幡知巳, 照井祐介, 佐武利彦, 前川二郎, 安村和則, 伊吹愛, et al. ポリアミンによるグリコサミノグリカン合成調節機構の解明. 日本薬学会年会要旨集(CD-ROM). 2017. 137th. 3. ROMBUNNO.25V-am02S-53
中村瑞穂, 斎木遼太郎, 斎木遼太郎, 植村武史, 坂本明彦, 朴恵林, 西村和洋, 照井祐介, 戸井田敏彦, 柏木敬子, et al. 脳梗塞時NMDA受容体により流入するCa²⁺による毒性物質アクロレインの産生. 日本生化学会大会(Web). 2015. 88th. 3T21-09(3P0162) (WEB ONLY)
中村瑞穂, 植村武史, 斎木遼太郎, 斎木遼太郎, 坂本明彦, 朴恵林, 西村和洋, 照井祐介, 戸井田敏彦, 柏木敬子, et al. 脳梗塞時NMDA受容体により流入するCa²⁺によるポリアミン代謝毒性物質アクロレインの産生. 日本ポリアミン学会年会プログラム及び抄録集. 2015. 7th. 26
山下智子, 西村和洋, 斎木遼太郎, 奥平宏之, 當銘真悠子, 東恭平, 照井祐介, 藤原邦雄, 柏木敬子, 五十嵐一衛. 細胞周期進行におけるポリアミンの機能解析. 日本ポリアミン学会年会プログラム及び抄録集. 2013. 4th. 29
斎木遼太郎, 富取秀行, 菅波晃子, 水野聡美, 吉沢佑基, 益子崇, 田村裕, 西村和洋, 戸井田敏彦, キース・ウィリアムス, et al. スペルミンおよびイフェンプロジルの結合によるNMDA受容体GluN1及びGluN2BのN末端調節領域の構造変化. 日本生化学会大会プログラム・講演要旨集. 2012. 85回. 2T09-09

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Professional career (1)：

Ph. D. (Chiba University)

Work history (6)：

2024 - 現在 International University of Health and Welfare School of Pharmacy at Narita Professor
2020 - 2024 International University of Health and Welfare Department of Pharmacutical Sciences Professor
2010 - 2020 Chiba University Graduate School of Pharmaceutical Sciences
2005 - 2010 Chiba University Graduate School of Pharmaceutical Sciences
2001 - 2005 Chiba University Graduate School of Pharmaceutical Sciences

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Association Membership(s) (3)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , The Japanese Society of Polyamine research

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