Art

J-GLOBAL ID：201802269136736393   Reference number：18A0490634

Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers

NMDAチャンネル遮断薬としてのポリアミンメマンチンハイブリッドの設計,合成および評価【Powered by NICT】

Author (11)： Kumamoto Takuya (Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 732-8553, Japan) ,  Nakajima Marie (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo 202-8585, Japan) ,  Uga Reina (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo 202-8585, Japan) ,  Ihayazaka Naoko (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo 202-8585, Japan) ,  Kashihara Haruna (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo 202-8585, Japan) ,  Katakawa Kazuaki (Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo 202-8585, Japan) ,  Ishikawa Tsutomu (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan) ,  Saiki Ryotaro (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan) ,  Nishimura Kazuhiro (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan) ,  Igarashi Kazuei (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan) ,  Igarashi Kazuei (Amine Pharma Research Institute, Innovation Plaza at Chiba University, 1-8-15 Inohana, Chuo-ku, Chiba 260-8675, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 26  Issue： 3  Page： 603-608  Publication year： 2018 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： N-Methyl-d-aspartate (NMDA) re...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A0490634&from=J-GLOBAL&jstjournalNo=W0556A") }}

Thesaurus term： *channel ,  therapy ,  nervous system disease ,  receptor ,  *polyamine ,  NMDA antagonist ,  antagonism ,  Nerve ,  nervinum ,  central nervous system drug ,  central nervous system depressant ,  alicyclic compound ,  bridged compound ,  primary amine ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  dicarboxylic acid ,  secondary amine

Author keywords (5)： Polyamine ,  NMDA channel blocker ,  Alzheimer’s disease ,  Memantine ,  Guanidine

JST classification (4)： Synthesis of drugs  (GV01030F) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of antiprotozoan drugs and anthelmintics  (GW17080G) ,  Enzyme in general  (EB09010D)

Substance index (3)： Guanidine ,  Memantine ,  NMDA

Terms in the title (5)： NMDA ,  チャンネル ,  遮断薬 ,  設計 ,  評価