Rchr
J-GLOBAL ID：200901073861351098
Update date: Sep. 23, 2024
Kawamoto Seiji
カワモト セイジ | Kawamoto Seiji
Affiliation and department：
Job title：
Research Associate
Other affiliations (1)：
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広島大学健康長寿研究拠点 (HiHA)/拠点リーダー
Homepage URL (1)：
http://home.hiroshima-u.ac.jp/bunseika/
Research field (4)：
Immunology
, Applied molecular and cellular biology
, Applied biochemistry
, Food sciences
Research keywords (3)：
食シグナルによる難治性加齢疾患制御
, 食品機能
, 免疫制御
Research theme for competitive and other funds (25)：
- 2022 - 2025 新たに発見したフラバノン誘導体によるガン特異的な細胞老化誘導機構の解明
- 2020 - 2024 サンゴアレルギー発症とサンゴ由来蛍光蛋白質の関係解明とアレルギー診断技術への展開
- 2016 - 2019 Analysis of the mechanism of Allergic march mediated by allergen-specific IgE
- 2013 - 2016 Development of a next generation-diagnostic system for allergic disorders, a component-resolved diagnosis, to create personalized vaccines for allergen-specific immunotherapy
- 2013 - 2016 Analyses of the immune cells involving intestinal inflammation and its application for development of foods with intestinal barrier-protecting activity
- 2013 - 2015 Molecular basis of immunomodulatory effect of dietary alpha-glucans
- 2012 - 2015 A newly-found 'regulatory antibody': its immunosuppressive mechanisms and prevention of proinflammatory disorders
- 2012 - 2014 Development of IgE mimotope-antibody fusion derivatives specific for sensitized allergens
- 2011 - 2012 Challenges towards the generation of the dream immunosuppressant for the 21stcentury without permanent medication
- 2010 - 2012 Molecular characterization of sensitized house dust mite allergens for the generation of tailor-made vaccine
- 2008 - 2010 Elucidation of a novel anti-allergic mechanism of pulverized dietary fiber and its application
- 2006 - 2007 局所樹状細胞によるアトピー性皮膚炎病熊制御の分子機構
- 2005 - 2006 Exhaustive Allergenome Analysis of Japanese Cedar Pollen Allergen Molecules
- 2002 - 2004 Generation of oral vaccine for mite allergy
- 2000 - 2001 アトピーマウスにおけるアレルギー病態制御の分子機構
- 1998 - 2001 アレルギー病態制御の分子機構解析
- 1998 - 2001 Analysis of molecular mechanism underlying the pathogenesis of allergy
- 1998 - 2000 Microbial production of n-3 docosapentaenoic acid and development of its utilization
- 1998 - 1999 アトピー性皮膚炎モデルマウスを用いたアレルギー発症の分子機構に関する解析
- 1997 - アトピー予防効果を有する機能性食品素材の検索と作用機作の解明
- 1997 - ダニ・スギ花粉アレルゲン分子群の網羅的同定と次世代診断・治療法への展開
- 1997 - 肝移植トレランスの誘導メカニズム解明
- 1997 - Screening of atopy-preventive functional foodstuffs and educidation of their mode of action
- 1997 - High-throughput identification of house dust mite and cedar pollen allergen molecules and their application to diagnostic or therapeutic strategy to the next generation
- 1997 - Elucidation of mechanism underlying tolerance induction in liver transplantation
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Papers (69)：
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Akira Maeda, Kouki Hirano, Shunsuke Maeda, Ayana Okuizumi, Noriko Hirakawa, Kenji Baba, Takashi Fujimura, Seiji Kawamoto. A methoxyflavanone from the medicinal herb Perilla frutescens down-modulates Th17 response and ameliorates collagen-induced arthritis. Biochemical and biophysical research communications. 2022. 637. 294-299
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Akira Maeda, Takashi Fujimura, Noriko Hirakawa, Kenji Baba, Seiji Kawamoto. A Methoxyflavanone from Perilla frutescens Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells. Biological & pharmaceutical bulletin. 2022. 45. 10. 1581-1584
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Hori A, Fujimura T, Murakami M, Park J, Kawamoto S. Intravenous immunoglobulin (IVIg) acts directly on conventional T cells to suppress T cell receptor signaling. Biochemical and Biophysical Research Communications. 2020. 522. 3. 792-798
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Fujimura T, Lum SZC, Nagata Y, Kawamoto S, Oyoshi MK. Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy. Frontiers in immunology. 2019. 10. 1933-1933
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Abd El-Hafeez AA, Khalifa HO, Mahdy EAM, Sharma V, Hosoi T, Ghosh P, Ozawa K, Montano MM, Fujimura T, Ibrahim ARN, et al. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-κB, and STAT3. Pharmacological Reports. 2019. 71. 2. 289-298
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MISC (150)：
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河本 正次, 藤村 孝志, 秋 庸裕, 小埜 和久. ダニアレルゲン-特集 抗原学 最近の進歩 ; 吸入性抗原 : 最近の進歩. アレルギー・免疫 = Allergology & immunology. 2017. 24. 1. 28-33
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K. G. ElRamlawy, T. Fujimura, G. Sumida, R. Murakami, A. Tanaka, T. Hayashi, T. Aki, K. Ono, S. Kawamoto. The challenge towards discrimination of clinical symptoms by component-resolved diagnosis using a repertoire of recombinant house dust mite allergens. ALLERGY. 2016. 71. 188-188
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Amer Ali Abd El Hafeez Mohamed, Takashi Fujimura, Rikiya Kamei, Noriko Hirakawa, Kenji Baba, Miyako Nakano, Kazuhisa Ono, Seiji Kawamoto. A novel methoxyflavanone from a Chinese medicinal herb (Perilla frutescens) induces G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma cells. CANCER RESEARCH. 2016. 76
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K. Koyamatsu, A. R. N. Ibrahim, K. Mizuno, G. Kumagai, D. Nishioka, T. Aki, K. Ono, S. Kawamoto. A serine protease allergen from Japanese cedar pollen induces thymic stromal lymphopoietin (TSLP) secretion from human epithelial cells. ALLERGY. 2014. 69. 592-592
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Y. Kishikawa, S. Kawamoto, H. Nakahara, Y. Watakabe, Y. Oto, T. Aki, Y. Asaoku, T. Hayashi, A. Tanaka, K. Ono. Component-resolved molecular diagnosis of house dust mite allergy using a comprehensive repertoire of recombinant allergens. ALLERGY. 2013. 68. 88-88
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Patents (9)：
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α-グルコシダーゼ及びその製造方法 並びに該α-グルコシダーゼを利用して製造したエチル-α-グルコシド及びその製造方法
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免疫抑制物質
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IgE産生抑制剤
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新規なスギ花粉アレルゲン遺伝子および該遺伝子がコードするタンパク質またはその抗原性断片
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アレルゲン遺伝子による形質転換乳酸菌
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Books (1)：
Education (4)：
- - 1996 Kyushu University
- - 1996 Kyushu University Graduate School, Division of Agriculture Graduate School of Genetic Resources Technology
- - 1991 Kyushu University School of Agriculture
- - 1991 Kyushu University Faculty of Agriculture Department of Food Science and Technology
Professional career (1)：
- Ph.D. (Kyushu University)
Work history (8)：
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