Nobuo Tsukamoto

ツカモトノブオ | Nobuo Tsukamoto

Affiliation and department：
Job title： Research Associate/Assistant Professor/Instructor

Research field (6)： Experimental pathology , Biological, health, and medical informatics , Molecular biology , Immunology , Cell biology , Tumor diagnostics and therapeutics

Research keywords (5)： signal transduction , tumor antigen , metabolism , immunosuppression , tumor immunology

Research theme for competitive and other funds (13)：

2019 - 2022 Berberineによる抗腫瘍免疫増強効果の機構解明と効果的な併用免疫療法の開発
2016 - 2019 がん微小環境における不均一な免疫抑制機構の解明と有効な抗腫瘍免疫誘導法の開発
2013 - 2016 Study on roles of aryl hydrocarbon receptor (AhR) in tumor microenvironment and estimation of AhR as a therapeutic target for cancer patients
2013 - 2015 Systematic analysis of cellular signaling involved in the melanoma induced immunosuppression
2011 - 2014 Development of effective immunotherapy by combining interventions on key points in the anti-tumor immune network

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Papers (19)：

Tomonari Kinoshita, Chie Kudo-Saito, Reiko Muramatsu, Tomonobu Fujita, Miyuki Saito, Haruna Nagumo, Toshiharu Sakurai, Shinobu Noji, Emi Takahata, Tomonori Yaguchi, et al. Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma. EUROPEAN JOURNAL OF CANCER. 2017. 86. 15-27
Matsushita M, Ozawa K, Suzuki T, Nakamura M, Nakano N, Kanchi S, Ichikawa D, Matsuki E, Sakurai M, Karigane D, et al. CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients. Blood Cancer J. 2017. 7. e601
T. Kinoshita, R. Muramatsu, T. Fujita, H. Nagumo, T. Sakurai, S. Noji, E. Takahata, T. Yaguchi, N. Tsukamoto, C. Kudo-Saito, et al. Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small-cell lung cancer. ANNALS OF ONCOLOGY. 2016. 27. 11. 2117-2123
Chie Kudo-Saito, Hiromi Shirako, Misa Ohike, Nobuo Tsukamoto, Yutaka Kawakami. CCL2 is critical for immunosuppression to promote cancer metastasis. CLINICAL & EXPERIMENTAL METASTASIS. 2013. 30. 4. 393-405
Kawakami Y, Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Iwata-Kajihara T, Nakamura S, Nishio H, Satomi R, Kobayashi A, et al. Cancer-induced immunosuppressive cascades and their reversal by molecular-targeted therapy. Ann N Y Acad Sci. 2013. 1284. 80-86

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Books (3)：

Cancer Induced Immunosuppression and its Modulation by Signal Inhibitors in “Resistance of cancer cells to CTL-mediated immunotherapy”
Springer. 2015
Development of personalized combination cancer immunotherapy based on the patients’ immune status in “Inflammation and immunity in cancer ”
Springer. 2015
Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor associated microenvironments. in “The Tumor Immunoenvironment”
Springer Science. 2013

Lectures and oral presentations (59)：

がん微小環境の代謝制御による免疫チェックポイント阻害薬の治療効果増強
(第22回日本がん免疫学会総会 2018)
Signal crosstalk of aryl hydrocarbon receptor (AhR) and IDO phosphorylation in tumor microenvironment
(第45回日本免疫学会総会・学術集会 2016)
Molecular mechanisms of immunosuppression by aryl hydrocarbon receptor (AhR) in tumor microenvironment
(第44回日本免疫学会総会・学術集会 2015)
Immunosuppression by downstream molecules regulated by aryl hydrocarbon receptor (AhR) in tumor microenvironment
(第43回日本免疫学会総会・学術集会 2014)
Augmentation of anti-tumor immune responses by Kampo medicine compounds with aryl hydrocarbon receptor (AhR) antagonistic activity
(第42回日本免疫学会総会・学術集会 2013)

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Education (2)：

2000 - The University of Tokyo Graduate School, Division of Medical Sciences 病因・病理学
1996 - Kyoto University Faculty of Science Division of Biophysics

Professional career (2)：

Master of Science (Kyoto University)
Doctor of Philosophy (The University of Tokyo)

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