Kazuo Tsubota

2014 - 2017 The association of retinal thickness measurements with cognitive impairment in a Japanese population

2014 - 2016 Metabolite profiles and age-related macular degeneration

2013 - 2016 Elucidation of the mechanism to control tear secretion by anti-aging approach

2013 - 2016 Development of technologies for next-generation regenerative therapies

2013 - 2015 The energy metabolism and tear secretion

2011 - 2013 Focus on mechanism of chronic ocular graft-vessus-host disease caused by donor-derived mesenchymal stem cells toward development of new treatment.

2010 - 2012 Evaluation of mechanisms by which caloric restriction regulates mitochondrial function

2010 - 2012 Molecular mechanism of dry eye disease

2010 - 2011 Molecular mechanism of gender gap in dry eye disease

2009 - 2010 A semaphorin 3A inhibitor accelerates cornel reinnervation following penetrating keratoplasty on mice

2008 - 2010 Analysis of the onset of ocular chronic graft versus host disease caused by donor-derived fibroblasts and the development of the new therapeutic intervention

2008 - 2009 IP3受容体およびムスカリニック受容体欠損マウスを用いた涙液分泌機構

2007 - 2008 The mechanism of peripheral nerve regeneration following corneal transplantation on mice

2007 - 2008 The role of anti-oxidative enzyme SOD1 on the development of hepatocellular carcinoma from steatohepatitis

2005 - 2007 Pathophysiology of conjunctival goblet cells

2005 - 2006 DEVELOPMENT OF CULTURE METHODS FOR EXOCRINE GLAND STEM CELLS USING GENE-TRANSDUCED FEEDER CELLS AND THEIR APPLICATION FOR TREATMENT

2005 - 2006 Searching the tissue specific autoimmune disease related gene by linkage analysis and establishment of a diagnosis method

2004 - 2005 The mechanism of exocrine gland disorder through estrogen and/or endocrine disruptors

2003 - 2004 Expression of the fetal HLA-G molecule by ocular surface epithelium is enhanced when expanded on amniotic membranes

2001 - 2004 涙液産生におけるアクアポリン5の生理的役割の解明

2002 - 2003 Identification of animal model for autoimmune disease using conditional expression of transgene

2001 - 2001 シェーグレン症候群診断基準査定調査の企画

2000 - 2001 Enhanced lacrimation and salivation in prolactin transgenic rats

1998 - 1999 A study on adhesion and retainment of saliva on the oral surface in the patient with xerostomia and Sjogren's syndrome

1998 - 1999 An organ-specific autoantigen for Sjogren's syndrome induced by Epstein-Barr virus activation

1997 - 1998 眼温度測定と気化熱解析による生体の水濡れ性測定機

1996 - 1998 Lacrimal gland transplantation for improvement of the gland function

1996 - 1997 Establishment of in vitro model for the Epstein-Barr virus reactivation in Sjogren's syndrome

1996 - 1997 Immunohistological analysis of TGF-beta1 expression in salivary glands

1995 - 1997 Detection of possible factors for the Epstein-Barr virus reactivation in Sjogren's syndrome

1995 - 1996 HLA-DNA ANALYSIS IN CORNEAL TRANSPLANTATION

1994 - 1995 Analysis of temperature on the oral surface and saliva evaporation from the oral surface in the patients with xerostomia and Sjogren's syndrome.

1993 - 1994 HLA-DNA ANALYSIS IN CORNEAL TRANSPLANTATION

1992 - 1993 眼乾燥症(ドライアイ)の病因論に関する免疫学的、分子生物学的研究