Rchr
J-GLOBAL ID:200901082912583460
Update date: Aug. 29, 2023
Shimasaki Takeo
シマサキ タケオ | Shimasaki Takeo
Affiliation and department:
Job title:
Assistant Professor
Research theme for competitive and other funds (9):
- 2018 - 2020 膵がん細胞のexosomeを介した浸潤性伝播の解明とその抑制剤の開発
- 2015 - 2017 抗がん剤による膵がん細胞の浸潤形質獲得の分子機構の解明とがん治療への応用
- 2015 - 2015 進行膵癌とそのエキソソームをダブルターゲットとした治療薬の開発
- 2013 - 2013 GSK3βを標的治療とした既存医薬品による膵がんの新規治療
- 2011 - 2013 化学療法により誘発されるEMT誘導因子の同定とその制御による膵がん治療法の開発
- 2012 - 2012 GSK3β阻害作用を持つ医薬品を用いた難治性膵癌の新規治療法の開発
- 2008 - 2009 GSK3βのがん促進機能の分子機構解明とその阻害に基づく消化器がん治療法の開発
- 2007 - 2008 塩酸ゲムシタビンによる膵がん細胞のEMT誘導の検証と分子細胞機構の解明
- 2006 - 2006 膵癌における塩酸ゲムシタビン耐性克服法の開発
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Papers (53):
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Yasuhiko Taki, Atsushi Fuku, Yuka Nakamura, Terutsugu Koya, Hironori Kitajima, Ikuhiro Tanida, Takashi Takaki, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Takeo Shimasaki, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara. A morphological study of adipose-derived stem cell sheets created with temperature-responsive culture dishes using scanning electron microscopy. Medical Molecular Morphology. 2022. 55. 3. 187-198
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Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y, Yamada H, Ohtomo K, Ishisaka T, Okano K, Ogawa T, Tsuji H, Matsuo Y, Minamoto T, Tomosugi N, Ferain E, Ochiya T. Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate. micromachines. 2021. 12. 1431
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Tasuku Hayashi, Tomoyuki Shibata, Masakatsu Nakamura, Naoko Sakurai, Hikaru Takano, Masafumi Ota, Tomoe Nomura-Horita, Ranji Hayashi, Takeo Shimasaki, Toshimi Ostuka, Tomomitsu Tahara, Tomiyasu Arisawa. MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa. GENETIC TESTING ANDMOLECULAR BIOMARKERS. 2021. 25. 255-262
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Takano Hikaru, Shibata Tomoyuki, Nakamura Masakatsu, Sakurai Naoko, Hayashi Tasuku, Ota Masafumi, Nomura-Horita Tomoe, Hayashi Ranji, Shimasaki Takeo, Otsuka Toshimi, Tahara Tomomitsu, Arisawa Tomiyasu. Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa. BMC Medical Genetics. 2020. 21. 1. 205-205
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Naoko Sakurai, Tomoyuki Shibata, Masakatsu Nakamura, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura-Horita, Ranji Hayashi, Takeo Shimasaki, Toshimi Ostuka, Tomomitsu Tahara, Tomiyasu Arisawa. Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis. BMC Medical Genetics. 2020. 21. 1. 201-201
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Books (4):
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Distinct pathologic role for glycogen synthase kinase 3β in colorectal cancer progression
InTech 2012 ISBN:9789535100621
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Stress responses of pancreatic cancer cells and their significance in invasion and metastasis
Springer 2012
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コラム4: ステージ分類とは?,第7章がんについてよくある質問: がん登録とは?
2010
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Gemcitabine changes the gene expression in human pancreatic cancer cells :search for new therapeutic molecular targets
Springer 2009
Lectures and oral presentations (101):
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Inhibitor of GSK3β may impedes the Development of Reflux-Induced Esophageal
(The 33rd Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 2022)
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THE PRE-MICRORNA938,TARGETING 1L-17L 3'-UTR,GENE POLYMORPHISMS IS ASSOCIATED WITH THE RISK FOR DAP-KINASE HYPERMETHYLATION IN HP INFECTED JAPANESE SUBJECTS
(DDW2017 2017)
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Observation of extracellular vesicles under scanning electron microscope
(2015)
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ヒト由来細胞外小胞の解析
(2015)
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Identification of the GSK3 beta-mediated secretory protein responsible for GEM-induced EMT in pancreatic cancer cells.
(2014)
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Education (2):
- 1997 - 2002 Kanazawa University Graduate School
- 1987 - 1993 Hamamatsu University School of Medicine Faculty of Medicine
Professional career (1):
Awards (6):
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