YASUHIRO TAKESHIMA

2017 - 2020 Non-invasive system for predicting effectiveness of the exon skipping therapy for muscular dystrophy

2016 - 2019 東アジアにおける筋ジストロフィーオーダーメイド治療開発のための分子疫学的調査

2014 - 2017 Pathogenic microorganism identification in neonatal infectious diseases by a meta-genomic analysis using the next generation sequencer

2014 - 2017 Investigation of inflammatory factors affecting the efficacy of the molecular therapies for muscular dystrophy

2013 - 2015 Cloning of non-dystrophin transcript from the dystrophin gene

2011 - 2013 Correlation between cis-acing elements and effects on inducing exon skipping

2011 - 2013 Investigation of fibrotic factors during the exon-skipping therapy using antisense oligonucleotide for muscular dystrophy

2010 - 2012 Establishment of treatment strategy for spinal muscular atrophybased on the SMN2gene transcription control

2009 - 2011 Genes responsible for mental retardation complicating to Duchenne muscular dystrophy

2008 - 2010 Research of signal transduction system in antisense therapy for muscular dystrophy

2007 - 2008 Study on treatment of Duchenne muscular dystrophy by inducing exon skipping

2006 - 2007 Research of antisense oligonucleotide therapy for muscular dystrophy using knockout mouse as a model

2006 - 2007 Development of Therapy for Spinal Muscular Atrophy Based on the Spliring Modulation Technology

2005 - 2006 Elucidation of adverse events of methotrexate based on genomic and proteomic analysis in childhood leukemia patients

2004 - 2006 筋ジストロフィー児の認知・言語と遺伝子異常

2004 - 2006 Molecular epidemiolojial study on maple syrup urine disease in Philippine.

2004 - 2005 Research of novel treatment for childhood leukemia by disrupting the chimeric gene function using RNAi

2004 - 2005 Cellular biological study on the treatment of Duchenne muscular dystrophy with nucleic acids

2003 - 2004 Cloning of chimera mRNA from acute myelomegakaryocytic leukemia cell with t(1;9)

2003 - 2004 Development of a new treatment with splicing modulators for spinal muscular atrophy

2003 - 2004 Molecular epidemiology of neonatal Gilbert's syndrome in Malaysia

2002 - 2003 Prevention of developmental disorders of intra-uterine growth retarded infants with growth factors.

2002 - 2003 Molecular genetic study on maple syrup urine disease in Philippines

2002 - 2003 Protection of neonatal brain against hypoxic-ischemic injury through regulating apoptosis.

2001 - 2003 Study on the treatment of Duchenne musclar dystrophy with chimera RNA/DNA

2001 - 2002 Evaluation of the analytical methods of antisense oligonueleotide applicable to the antisense therapy

2001 - 2002 Research for the exonic splicing enhancer sequences in dysttrophin gene

2001 - 2002 Molecular genetic study of frontoethmoidal encephalocele in Indonesia

2001 - 2001 ジストロフィンmRNA前駆体に結合する新規核タンパクに関する分子生物学的研究

2000 - 2001 Establishment of treatment of Duchenne muscular dystrophy

2000 - 2000 ジストロフィンmRNA前駆体のスプライシングに関与する新規タンパクのクローニング

1999 - 2000 エクソンスキッピング誘導による筋ジストロフィー遺伝子治療に関する研究

1999 - 2000 Molecular genetic study on G6PD deficiency in Philippines

1998 - 1999 Establishment of treatment of Duchenne muscular dystrophy

1997 - 1999 Study on dystrophin isoform expressed in heart

1998 - 1998 ジストロフィン遺伝子からの新規転写産物のクローニング

1997 - 1998 アンチセンスオリゴDNA筋肉内投与による筋ジストロフィー遺伝子治療に関する研究

1997 - 1997 血清中DNAのマイクロサテライトを解析するがんの早期診断法の確立

1996 - 1996 アンチセンスオリゴヌクレオチドを用いた筋ジストロフィー遺伝子治療に関する研究

1996 - 1996 神経線維腫症1型遺伝子異常の蛋白発現ベクターを応用した診断法の確立