Rchr

J-GLOBAL ID：200901085983212151 Update date: Feb. 01, 2024

Morimatsu Masami

モリマツマサミ | Morimatsu Masami

Affiliation and department：
Job title： Laboratory of Animal Experiment for Disease Model

Research field (3)： Experimental pathology , Veterinary medicine , Laboratory animal science

Research keywords (6)：獣医生化学 , 分子遺伝学 , 実験動物学 , Veterinary Biochemistry , Molecular Genetics , Laboratory Animal Science

Research theme for competitive and other funds (33)：

2022 - 2025 NFkB情報伝達系が癌発症に及ぼす影響におけるNFKBIZの機能解明
2020 - 2023 感受性責任遺伝子探索による多包虫症の寄生体・宿主相互作用の分子機序の解明
2018 - 2021 腫瘍におけるBRCA2の変異と結合分子群の機能解明を目的とした新規モデルの作出
2014 - 2017 Anti-tumor mechanism of soluble form of sialic acid-recognizing protein, Siglec-9
2014 - 2016 組換え酵素Rad51と癌抑制タンパク質BRCA2の結合の種間比較に基づく分子創薬

2012 - 2014 Mechanisms of development of AIDS encephalopathy using a new transgenic mouse model expressing HIV-1 Nef

2011 - 2013 Tumorigenic effects of BRCA2 mutation and genomic instability in dogs

2010 - 2012 Biological function and gene regulation of epididymal-specific carboxylesterase (CES4)

2009 - 2011 Regulation Mechanisms of the body size in mice

2007 - 2009 Analysis of a novel NFkB inhibitor deficient mouse as a model for atopic dermatisis

2005 - 2006 Expression and role of sugar-recognition molecule galectin in the digestive tract

2005 - 2006 新規アトピー性皮膚炎原因遺伝子の機能解析

2003 - 2006 Molecular and clinical analysis for metastasis and invasion of cancers in small animals

2004 - 2005 ウシ肝cDNAマイクロアレイの評価と妊娠ウシ肝の特異発現遺伝子の検索

2003 - 2005 Regulation of host defense and development by innate-immunity signal transduction system

2003 - 2004 ジーンターゲティングによる新規アトピー性皮膚炎モデル動物の開発

2001 - 2003 Development of hantavirus vaccine and rapid diagnosis kit by using soluble recombinant envelope glycoproteins

1999 - 2001 DNA repair defect, tumorigensis, and hereditary breast cancer gene Brca2 -Studies in vitro and in vivo, and association with Rad51.

1999 - 2001 Study for the development of new gene targeting method utilizing epitope tags

1999 - 2000 Fundamental studies on the protective mechanisms of a novel serum lectin (CBPb01)

1999 - 1999 近赤外光を用いたイヌの脳活動の無侵襲計測 - イヌのこころの動きを測る

1997 - 1998 急性相タンパク質の新規動物資源生産管理および野生動物生態調査への応用

1995 - 1996 Neuroendocrine mechanism of stress-induced immunosuppression and roles of cytokines.

1995 - 1995 ウシ肝細胞における急性相タンパク質の遺伝子発現調節機構の解析

1994 - 1994 ウシハプトグロビン遺伝子の構造および転写調節機構の解析

1993 - 1994 Molecular mechanisms of the central actions of interleukin-1

1993 - 1993 ウシの初代培養肝細胞を用いた急性相タンパク質の遺伝子発現・合成調節機構の解析

炎症反応の制御に関わる細胞情報伝達機構

相同組換え反応の分子機構

家畜の急性相タンパク質の合成・分泌調節機構

Signal transduction mechanisms in the inflammatory response

Molecular mechanisms of homologous recombination.

Mechanisms of the synthesis and secretion of acute-phase proteins in domestic animals.

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Papers (117)：

Zida Zhu, Taisuke Kitano, Masami Morimatsu, Kazuhiko Ochiai, Toshina Ishiguro-Oonuma, Kosuke Oosumi, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa. A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats. Veterinary sciences. 2023. 10. 2
Kei Shimakawa, Kazuhiko Ochiai, Sachi Hirose, Eri Tanabe, Masaki Michishita, Motoharu Sakaue, Yasunaga Yoshikawa, Masami Morimatsu, Tsuyoshi Tajima, Masami Watanabe, et al. Canine Mammary Tumor Cell Lines Derived from Metastatic Foci Show Increased RAD51 Expression but Diminished Radioresistance via p21 Inhibition. Veterinary sciences. 2022. 9. 12
Marika Maeda, Kazuhiko Ochiai, Masaki Michishita, Masami Morimatsu, Hiroki Sakai, Nayuta Kinoshita, Motoharu Sakaue, Eri Onozawa, Daigo Azakami, Masami Yamamoto, et al. In vitro anticancer effects of alpelisib against PIK3CA-mutated canine hemangiosarcoma cell lines. Oncology reports. 2022. 47. 4
Zida Zhu, Taisuke Kitano, Masami Morimatsu, Arisa Tanaka, Ryo Morioka, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa. BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents. International Journal of Molecular Sciences. 2022. 23. 7
植村光希, 落合和彦, 道下正貴, 吉川泰永, 前田まりか, 森松正美, 近江俊徳, 田中良和. イヌとヒトで異なるRAD51分子構造がDNA相同組換え修復効率におよぼす影響の検討. 日本獣医学会学術集会講演要旨集. 2021. 164回. [IO-11]

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MISC (73)：

吉川泰永, 森松正美, 上妻創, 折野宏一. 癌抑制遺伝子BRCA2の翻訳効率に影響を与えるスプライシングバリアント. 日本獣医学会学術集会講演要旨集. 2020. 163rd
植村光希, 落合和彦, 森松正美, 柏木伸旭, 宇埜友美子, 道下正貴, 呰上大吾, 小野沢栄里, 近江俊徳. イヌRAD51変異が複合体形成におよぼす影響の検討. 日本獣医学会学術集会講演要旨集. 2019. 162回. 479-479
中沢綾香, 石黒(大沼)俊名, 落合和彦, 森松正美, 木崎景一郎. がん抑制遺伝子p53に変異を有するイヌ乳腺腫瘍細胞に対する血管新生阻害薬の抗腫瘍効果の解析. 日本獣医学会学術集会講演要旨集. 2019. 162nd
吉川泰永, 森松正美, 落合和彦, 田中杏里咲, 折野宏一. BRCA2のC末端RAD51結合領域におけるRAD51との結合に影響を与えるアミノ酸残基の同定. 日本獣医学会学術集会講演要旨集. 2019. 162nd
落合和彦, 平間日奈子, 森松正美, 川上翔太, 道下正貴, 中川貴之, 呰上大吾, 稲垣健志, 坂本敦司, 近江俊徳. イヌ乳腺腫瘍細胞株で生じたp53遺伝子変異の検出と機能解析. 日本獣医学会学術集会講演要旨集. 2018. 161回. 431-431

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Patents (5)：

Lectures and oral presentations (126)：

癌抑制遺伝子Brca2のイントロン1における発現調節機構の解析
(第164回日本獣医学会学術集会 2021)
イヌとヒトで異なるRAD51分子構造がDNA相同組換え修復効率におよぼす影響の検討
(第164回日本獣医学会学術集会 2021)
p53変異イヌ乳腺腫瘍細胞株CTB-m2の性状解析
(第163回日本獣医学会学術集会 2020)
癌抑制遺伝子BRCA2の翻訳効率に影響を与えるスプライシングバリアント
(第163回日本獣医学会学術集会 2020)
可溶型Siglec-9による気道炎症抑制効果の検証
(第163回日本獣医学会学術集会 2020)

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Education (4)：

- 1992 Hokkaido University Graduate School of Veterinary Medicine
- 1992 Hokkaido University Graduate School, Division of Veterinary Medicine
- 1989 Hokkaido University Faculty of Veterinary Medicine
- 1987 Hokkaido University School of Veterinary Medicine Veterinary Medicine

Professional career (1)：

PhD (Hokkaido University)

Work history (12)：

2022/04 - 現在 Faculty of Veterinary Medicine Hokkaido University Laboratory of Laboratory Animal Science and Medicine Department of Applied Veterinary Sciences Professor
2013/11 - 2022/12 Faculty of Veterinary Medicine, Hokkaido University Attending Veterinarian of Animal Facility
2013/11 - 2022/03 Faculty of Veterinary Medicine, Hokkaido University Laboratory of Laboratory Animal Science and Medicine Department of Applied Veterinary Sciences Associate Professor
2012/04 - 2013/10 Institute for Genetic Medicine, Hokkaido University Laboratory of Animal Experiments Director
2008/07 - 2013/10 Institute for Genetic Medicine, Hokkaido University Disease Model Innovation Associate Professor

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Committee career (18)：

2023/02 - 現在 Editorial Board Member "Animals"
2022/06 - 現在 Japanese College of Laboratory Animal Medicine (JCLAM) Committee for Information Technology
2022/05 - 現在 Japanese Association for Laboratory Animal Science (JALAS) Assessment and Verification Committee
2022/05 - 現在 Japanese Association for Laboratory Animal Science (JALAS) Board of Directors
2022/04 - 現在 Japanese College of Laboratory Animal Medicine (JCLAM) Board of Directors

2020 - 現在 Japanese Association for Laboratory Animal Science (JALAS) Committee for the Act on Welfare and Management of Animals and its related matters

2020 - 現在 Japanese Association for Laboratory Animal Science (JALAS) Committee for Training System of Laboratory Animal Manager

2019/03 - 現在 Editorial Board Member of "Biomedical Research"

2018 - 現在 Japanese Association for Laboratory Animal Science (JALAS) Committee for laboratory animal welfare and ethics

2016 - 現在 Japanese Association for Laboratory Animal Science (JALAS) Committee for the Training of Site Visitors in Verification and Validation Programs for Proper Conduct of Animal Experimentations

2014 - 現在 Japanese Association for Laboratory Animal Medicine (JALAM) Board of Directors

2020 - 2022 Japanese Association of Laboratory Animal Facilities of National University Corporation Committee for Academic Information and Public Relations

2019 - 2022 Japanese Association of Laboratory Animal Facilities of National University Corporation Committee for Medium Size Animals

2016 - 2022 Japanese Association for Laboratory Animal Science (JALAS) Committee for the Review of Association Articles, Bylaws and Regulations

2019 - 2021 Japanese College of Laboratory Animal Medicine (JCLAM) Committee for Examination Review

2018 - 2019 Japanese Association for Laboratory Animal Science (JALAS) Board of Directors

2012 - 2015 Japanese College of Laboratory Animal Medicine (JCLAM) Examination Committee/Examination Test-writing Committee

2015 - Japanese Association for Laboratory Animal Medicine and Japanese College of Laboratory Animal Medicine Joint Ad hoc Committee of for the Development of the Position Statement for Analgesia, Anesthesia, and Euthanasia of Rodent Fetuses and Neonates

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Association Membership(s) (13)：

JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY OF VETERINARY SCIENCE , The Japanese College of Laboratory Animal Medicine (JCLAM) , The Japanese Association for Laboratory Animal Medicine (JALAM) , JAPAN VETERINARY MEDICAL ASSOCIATION , 日本実験動物医学専門医協会 , 日本実験動物医学会 , 日本実験動物学会 , 日本分子生物学会 , 日本生化学会 , 日本獣医学会

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