Research field (2)：
Oral medicine
, Surgical dentistry
Research theme for competitive and other funds (97)：
2014 - 2017 口腔がん由来エクソソームによる血管内皮の異常性獲得機構の解明
2013 - 2017 Analysis of cisplatin resistance of PTP4A1 and identification of new endogenous resistance gene to cisplatin
2013 - 2016 Development of new treatment strategy targeting for vascular niche of oral cancer stem cell
2013 - 2016 Application of biglyan as tumor biomarker of oral cancer
2013 - 2016 Development and evaluation on safety of Hybrid nano biomaterial for reconstruction for oral and maxillofacial region
2013 - 2016 The effects of liposomal LF on growth, invasion and bone destruction of oral squamous cell carcinoma (OSCC)
2013 - 2016 Comprehensive analyses of the mechanism of bone destruction by oral cancer
2014 - 2015 がん微小環境の多様性に関与するmiRNAの同定とがんの診断・治療への応用
2013 - 2015 Development of cancer sensor by utilizing oncolytic virus
2012 - 2015 Decay of RNA binding protein involved in oral oncogenesis
2012 - 2015 Development of novel therapy targeting cancer stem cells by ROS regulation
2012 - 2014 Attempt to control ARE-mRNA expressed in oral cancer cells
2012 - 2014 口腔環境が口腔がんの悪性化・上皮間葉移行を誘導する機構の解明
2011 - 2014 Development of new oncolytic adenovirus
2011 - 2014 腫瘍血管内皮細胞の幹細胞性と薬剤耐性獲得機構との関わりの解明
2011 - 2014 Analysis of oral cancer oncogenic mechanism mediate by the export and stabilization of ARE-mRNA
2011 - 2012 The basic study of the oral cancer stem cell by utilizing single cell cloning method
2011 - 2012 Targeting tumor metastasis by normalization of tumor blood vessels
2011 - 2012 Novel oncogenic mechanism of oral cancer mediated by HPV
2010 - 2012 Original approach to obtain intrinsic resistance genes to cisplatin
2009 - 2012 Elucidation of invasive andmetastatic mechanism in oral cancer for application to molecular based diagnosisand gene therapy
2010 - 2011 Basic research for oral cancer diagnosis estimated by HuR export
2009 - 2011 Application of EPC for tissue regeneration
2009 - 2011 Export of RNA-protein complex and oncogenesis
2008 - 2011 Exploitation of gene-targeting therapy based on the cellular and biological features of oral-carcinoma stem cell and tumor microenvironment.
2009 - 2010 血管新生阻害療法に対する腫瘍血管内皮細胞の抵抗性獲得の機序解析
2008 - 2010 Development of novel antiangiogenic therapy based on tumor microenviroenment
2008 - 2010 Basic research for cancer therapy by knockdown of RNA binding protein
2007 - 2009 Detection of cervical lymphnode micrometastasis in oral cancer
2007 - 2009 Oral Tissue Reconstruction with 3D Scaffolds and Surface Modification Using Carbon Nanotubes
2007 - 2008 Roles of p53 family proteins on the risk-factor of recurrence in oral squamous cell carcinomas.
2006 - 2007 顎骨骨折・顎骨欠損への再生医療の試み-ポリリン酸による顎骨誘導-
2006 - 2007 Analysis of Tumor-associated Endothelial Cell Biology
2006 - 2007 Development of gene delivery system using nanocoloid and its application for gene targeting therapy
2006 - 2007 Gene Targeting Therapy against tumor endothelial cells
2006 - 2007 Export and stabilization of AU-rich element containng mRNA in oral cancer cells
2005 - 2006 RNAiの応用による新しい口腔がん遺伝子治療のための基礎研究
2005 - 2006 口腔がんの発症・進展におよぼす糖転移酵素GnT-Vの影響
2005 - 2006 転写因子相互作用による口腔がんの悪性形質獲得機構の解析
2005 - 2006 カーボンナノチューブ(CNTs)の生物学的特性を応用した再生療法の開発
2005 - 2006 Evaluation of pre-operative Chemoradiotherapy in Oral Squamous Cell Carcinoma. -Integration of molecular biology and clinical state-
2005 - 2006 An exploitation of gene targeting therapy against hypoxic condition of oral carcinoma.
2005 - 2006 Roles of Pim-1 oncogene in oral squamous cell carcinoma.
2005 - 2006 Histopathological evaluation of effects of sex hormones on carcinogenesis and morphological transformation of salivary gland carcinomas : Expression of estrogen receptor
2005 - 2006 ウイルスタンパクによるCRM1非依存的なARE-mRNAの核外輸送
2004 - 2006 Development of regenerative therapy for jaw bone using scaffold with carbon nanotubes.
2004 - 2005 Translation research for predicting the prognosis of oral malignant tumors.
2004 - 2005 Gene targeting therapy for oral carcinoma using adrenomedullin antagonisit.
2004 - 2005 Elucidation of the roles of Pim-1 induced under hypoxia in pancreatic cancer and its application to the cancer therapy
2003 - 2004 Bone regenerative medicine by introducing ets family of gene
2002 - 2004 骨芽細胞への分化で発現する遺伝子の導入細胞を用いた顎骨再生療法の開発
2002 - 2003 ポリリン酸による歯槽骨・顎骨再生医療の試み
2002 - 2003 Identification of HIF-1a target genes and their biological roles in oral carcinoma.
2002 - 2003 The removal system at irradiated apoptotic cells
2002 - 2003 Research on factors involved in prognosis of oral carcinoma.
2002 - 2003 Histopathological evaluation of the effects of sex hormones in DMBA-induced rat malignant salivary gland tumors with morphological transformation.
2002 - 2003 Development of therapy for pancreatic cancers which targets adaptation response to hypoxia.
2001 - 2003 Molecular etiological study on buccal carcinogenesis in Bangladesh
2001 - 2003 With the aim of expansion of the application of dental implants for the aged person and the patient who have systemic disease : the development of dental implants combined with the cell tranfected gene of bone related protein
2000 - 2003 MOLECULAR ETIOLOGICAL STUDY OF THE ORAL CANCER CARCINOGENESIS IN SRI-LANKA.
2001 - 2002 Induction of apoptosis in oral squamous cell carcinoma by activating caspase
2000 - 2002 With the aim of early convalescence of the occlusal function in the immediate implant after tooth extraction :
2000 - 2002 Interaction of osteoclasts and cancer cells in the process of bone invation of oral cancer
2000 - 2002 Analyses of relation between cytokine production, apoptosis and clinicopathological findings in Sjogren's syndrom patients
2000 - 2001 Gene therapy for oral squamous cell carcinoma targeting tumor specific promoter activation
2000 - 2001 Caspase cascades which activated by ionizing irradiation
2000 - 2001 The role of E1AF, an ets-oncogene family tranascription factor in cell cycle regulation.
2000 - 2001 Estrogen receptor expression and endocrine disruptors correlates with behavior and histological features of malignant epithelial tumors of the salivary gland
1999 - 2001 Analysis of carcinogenic process of oral leukoplakias and establishment of their treatment
1999 - 2000 Effects on gene expression of bone and cell-adhesive proteins by biomaterials
1999 - 2000 Relationship between expression of E1AF and histological malignancies of oral squamous cell carcinoma
1999 - 2000 An atempt of gene therapy for oral squamous cell carcinoma
1998 - 1999 吸啜から咀嚼への移行期における体性感覚伝達機構の発達
1998 - 1999 Identification of targetgenes of E1AF using two hybrid system
1998 - 1999 Bag1 and Yama/CPP32 expressions of SCC and its significance in radiosensitivity
1998 - 1999 Estrogen receptor expression correlates with differentiation and proliferative activity of adenocarcinoma of the salivary gland
1997 - 1999 Search for the bioactive molecules implicated in the regulation of human periodontal ligament cell functions
1997 - 1998 転写因子E1AFのがん細胞の浸潤活性の発現と細胞周期における役割
1996 - 1998 ESTABLISHMENT OF MOLECULAR DIAGNOSING STRATEGY FOR MALIGNANT TRANSFORMATION OF ORAL LEUKOPLAKIA
1996 - 1997 ABNORMALITIES IN DNA REPAIR AND GENOMIC IMPRINTING IN ORAL PRECANCEROUS LESIONS.
1996 - 1997 Inhibitory effects on tumor invasion and metastasis induced by transfection of anti-sense E1AF,an ets-oncogene family transcription factor.
Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindoh, Mutsumi Miyauchi, et al. Bovine Lactoferrin Suppresses Tumor Angiogenesis through NF-κB Pathway Inhibition by Binding to TRAF6. Pharmaceutics. 2023. 15. 1. 165-165
Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindoh, Mutsumi Miyauchi, et al. Bovine Lactoferrin Suppresses Tumor Angiogenesis through NF-κB Pathway Inhibition by Binding to TRAF6. Pharmaceutics. 2023. 15. 1
Misa Yanagiya, Randa I. H. Dawood, Nako Maishi, Yasuhiro Hida, Chisaho Torii, Dorcas A. Annan, Hiroshi Kikuchi, Aya Yanagawa Matsuda, Tetsuya Kitamura, Yoichi Ohiro, et al. Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma. Pathology International. 2021. 71. 6. 383-391
Yohei Mikawa, Mohammad Towfik Alam, Elora Hossain, Aya Yanagawa-Matsuda, Tetsuya Kitamura, Motoaki Yasuda, Umma Habiba, Ishraque Ahmed, Yoshimasa Kitagawa, Masanobu Shindoh, et al. Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA. Cancers. 2020. 12. 5
1983/01 - 1997/11 Hokkaido University School of Dental Medicine
1982/04 - 1982/12 Hokkaido University School of Dental Medicine
1978 - 1982 Graduate Student
1982 - Medical Staff,Department of Oral Surgery, Hokkaido University Dental Hospital
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Committee career (3)：
2011/09 - 現在 日本学術会議 連携会員(第2部)
2005/08 - 現在 日本臨床口腔病理学会 理事
1991/04 - 現在 日本病理学会 学術評議員
Awards (1)：
2006 - 日本病理学会学術研究賞
Association Membership(s) (12)：
JAPANESE STOMATOLOGICAL SOCIETY
, 日本分子生物学会
, 日本病理学会
, 歯科基礎医学会
, 日本癌学会
, アメリカ癌学会
, THE JAPANESE SOCIETY OF ORAL PATHOLOGY
, American Association for Cancer Research
, The Japanese Society for Oral Pathology
, Japanese Association for Oral Bioloby
, The Molecular Biology Society of Japan
, Japanese Cancer Association. Japanese Society of Pathology
