Yoshimoto Takayuki

2021 - 2024 脳卒中・脊髄損傷の後遺障害のリハビリテーション治療への漢方薬の応用

2021 - 2024 ヒト樹状細胞前駆細胞株とT細胞クローンを用いた新規アレルギー感作性評価法の開発

2019 - 2023 Oncofertility視点に基づく若年癌患者の性腺機能不全の漢方治療法の確立

2019 - 2022 A novel mechanism whereby EBI3, one of IL-27 cytokine subunits, augments target protein expression under inflammatory conditions

2019 - 2022 Development of a novel method to generate human iPS cell-derived dendritic cell progenitors and their effectiveness

2018 - 2021 Comprehensive study on IL-27, one of the IL-12 family cytokines, aiming at its clinical application for cancer immunotherapy

2018 - 2021 Inhibition of pulmonary fibrosis by mesenchymal stem cells through IL-27 and its clinical application

2018 - 2021 Development of a novel alternative to animal testing for the evaluation of respiratory allergic sensitizing potential of chemicals

2017 - 2020 Therapeutic effect of mesenchymal stem cells by anti-inflammatory cytokinesIL-27 and IL-35

2016 - 2020 Elucidation of the mechanism of action of novel antiepileptic drugs using functionalized magnetic nanoparticles and exploration of their neuroprotective effects

2015 - 2019 The effect of traditional medicine on busulfan- and/or irradiation-induced aspermatogenesis

2015 - 2018 A novel role for EBI3, a common subunit of IL-27 and IL-35, as a intracellular molecule in the augmentation of IL-23Ra protein expression

2015 - 2018 Identification and functional analysis of a novel IL-6/IL-12 family cytokine

2015 - 2018 Proliferation and Differentiation of naive helper T cells by Dendritic cells in Human

2015 - 2018 Regulation of the development of psoriasis by ASK1, a stress-responsive MAP kinase

2013 - 2016 Induction of IL-17-producing T cells by VEGF-A as starting molecule: Paradigm shift of psoriasis pathogenesis.

2013 - 2016 The roles and applications of IL-23 and IL-27 in new therapeutic strategies for malignant melanoma and psoriasis

2012 - 2016 Establishment of the differentiation method to spermatogenesis by the xenogeneic transplantation of spermatogonia stem cells and the in vitro culture

2014 - 2015 IL-27により分化誘導したDC前駆細胞を用いた新しい癌DCワクチン療法の開発

2013 - 2015 IL-27による造血幹細胞の運命決定メカニズムの解明

2012 - 2015 Study on the regulation of immune responses by a novel IL-6/IL-12 family cytokine

2012 - 2014 Development of a new cancer immunotherapy with dendritic cells and macrophages by IL-27

2011 - 2013 New mechanism whereby IL-23 regulates immune responses through Notch signalling

2010 - 2012 Basic studies on therapeutic utilities ofIL-27 for malignant melanoma, psoriasis and alopecia areata.

2008 - 2010 Immune regulation by the IL-6/IL-12 family cytokines

2007 - 2008 Analysis of mechanisms of the host defense against parasite infection by new cytokines (IL-27, IL-33)

2007 - 2008 Analysis of antitumor effect by antiangiogenic activity of interleukin-27

2006 - 2008 新しいIL-6/12関連サイトカインIL-27による造血幹細胞の増殖・分化の制御

2005 - 2005 Study of roles of bone microenvironment and immune system in establishment and progression of bone metastasis

2003 - 2004 Therapeutic Strategy for Squamous Cell Carcinoma Resistant to Chemotherapeutic Agents

2002 - 2003 Studies on the signal transduction passways through IL-12 receptor

2002 - 2003 Activation of Caspases via the Mitochondrial Pathway in Hepatocyte Apoptosis -Roles of IAPs and Smac-

2002 - 2003 Basic study for Analysis of Intractable Resistant Tumor Cells and their Overcoming in Cancer Gene Therapy

2001 - 2003 Clinical Application of Tumor-specific Anti-tumor Immunity Induced by Tumor Cells Expressing Fas (CD95) Ligand

2000 - 2000 Th1反応における情報伝達制御機構の解明-IL-12Rを介したIFN-γ産生へのシグナル伝達-

1999 - 2000 Studies on the regulation of IL-12 expression and function and its application to therapy

1999 - 1999 マラリア感染に対する防御免疫機構-赤内型P.berghel強毒株NK65とその弱毒株XATを用いた解析-

1999 - 1999 免疫機能低下の機構解明

1998 - 1999 Elucidation of the mechanism how Vβ T cells aggravate autoimmune diseases and establishment of T cell receptor (TCR)-targeted gene therapies of autoimmune diseases

1997 - 1999 Elucidation of T cell subset Th1 differentiation by IL-12

1998 - 1998 マラリア感染における防御免疫機構の研究-赤内型P.berghei強毒株NK65とその弱毒株XATを用いた検討-

1997 - 1998 Study on the role of IL-12 in protective immunity against infection

1997 - 1998 IL-12の発現調節及び作用機序に関する基礎的研究

1997 - 1997 IL-12遺伝子導入腫瘍を用いた抗腫瘍効果機序の基礎的研究

1996 - 1997 Amelioration of lpr^<cg>-induced autoimmune diseases with Vbeta8.2-specific viral superantigen and its application to gene therapy in mice

1996 - 1996 IL-12遺伝子をもちいた癌免疫療法開発の基礎的研究

1996 - 1996 IL-12による弱毒化マラリア原虫のワクチン効果増強に関する基礎的研究

1996 - 1996 IL-12の発現調節機構に関する基礎的研究

1995 - 1995 T細胞亜集団による免疫制御の分子機構

1995 - 1995 IL-12遺伝子をもちいた癌免疫療法開発の基礎的研究

1995 - 1995 FAS-FASリガンド実験系を用いたアポトーシスによる癌治療の基礎的研究

1995 - 1995 マウスインターロイキン12 (IL-12)の遺伝子構造及びその発現調節機構の解析

1994 - 1994 T細胞亜集団による免疫制御の分子機構

1994 - 1994 レトロウイルス感染による自己免疫疾患誘導の機構解明

1993 - 1993 T細胞亜集団による免疫制御の分子機構

1993 - 1993 先天性アミノ酸尿症の原因としてのヒト塩基性アミノ酸トランスポーターの同定

1992 - 1993 Analysis of cytokine cascade in inflammatory reaction and application for the regulation