Izawa Shingo

イザワシンゴ | Izawa Shingo

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://kityeast.wixsite.com/kit-yeast-group

Research field (4)： Applied microbiology , Applied biochemistry , Cell biology , Molecular biology

Research keywords (10)： protein denaturation , yeast , ethanol stress , brewing related stress , P-bodies , stress granules , translation repression , cold atmospheric pressure plasma , mRNA輸送 , ストレス応答

Research theme for competitive and other funds (27)：

2020 - 2023 翻訳抑制ストレス下で優先的に発現する遺伝子の網羅的解析による酵母の生存戦略の解明
2019 - 2022 Molecular basis of mRNA exporter's diversification by evolution of mRNA nuclear exporters in eukaryotic cells
2017 - 2020 Analysis of the molecular mechanism of preferential and selective translation of yeast and its application in the field of brewing and fermentation
2015 - 2018 Elucidation of the molecular mechanism of action of the yeast strongest DIT1 terminator and its application
2017 - 2018 Selective insulation and effective fermentation of lignocellulosic biomass

2017 - 2018 Selective gene expression under brewing-related stress in yeast cells

2014 - 2017 Analysis of mRNA export mechanism and applied mRNA biotechnology in eukaryote.

2014 - 2017 Improvement of yeast fermentability and stress tolerance through the modification of mRNA flux

2014 - 2015 Interaction of trans fats in yeast cells

2011 - 2013 Safety evaluation of trans fats using yeast system

2011 - 2013 Study on yeast mRNA flux in ethanol stress response and during the process of alcoholic fermentation

2009 - 2011 Study of the old relation between glutathione metabolism and polyamine metabo lism. from the basic study to the applied study

2008 - 2010 Study on the post transcriptional regulation of yeast gene expression under stressed conditions and brewing process

2006 - 2007 ストレス条件下および酒類醸造過程における酵母mRNAの選択的核外輸送機構の解析

2004 - 2005 レドックス調節因子チオレドキシンのアルコール発酵における機能と輸送機構の解析

1995 - 2003 Study on the adaptive mechanism against hydrogen peroxide stress in yeast

2002 - 2002 ストレス応答における核内チオレドキシンによるmRNA核外輸送のredox制御機構

2001 - 2002 Molecular mechanism for activation of yeast transcription factor Yap1 by post-translational modification

2001 - 2002 チオレドキシンシステムの核移行と同システムによる核外輸送のレドックス制御機構

2002 - Regulation of mRNA export in the stress response

2000 - 2001 Development of biodegradable plastics from various kinds of biomass and elucidation for the safety of biodegraded intermediates from them

1999 - 2000 酵母のストレス応答性転写因子YAP-1の活性と局在性のredox制御機構の解析

1998 - 1999 Intracellular dynamism of transcription factors and signal cross-talk in the stress response in yeast

1997 - 1998 酵母細胞の老化に伴う酸化的ストレス適応応答の変動機構の解析

1996 - 1997 Molecular evolution of the adaptive mechanisms against reactive oxygen stress in yeast

1996 - 1996 抗酸化酵素とGSH1遺伝子破壊株による酵母の過酸化水素ストレスへの適応機構の解析

Regulation of the redox conditions in the nucleus

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Papers (84)：

Ryoko Ando, Yu Ishikawa, Yoshiaki Kamada, Shingo Izawa. Contribution of the yeast bi-chaperone system in the restoration of the RNA helicase Ded1 and translational activity under severe ethanol stress. J. Biol. Chem. 2023. 299. 12. 105472
Vo Thi Anh Nguyet, Ryoko Ando, Noboru Furutani, Shingo Izawa. Severe ethanol stress inhibits yeast proteasome activity at moderate temperatures but not at low temperatures. Genes to Cells : devoted to molecular & cellular mechanisms. 2023. 28. 10. 736-745
Yoshiaki Kamada, Ryoko Ando, Shingo Izawa, Akira Matsuura. Yeast Tor complex 1 phosphorylates eIF4E-binding protein, Caf20. Genes to Cells : devoted to molecular & cellular mechanisms. 2023
Shizu Fukuda, Yasuhiro Sakurai, Shingo Izawa. Detoxification of the post-harvest antifungal pesticide thiabendazole by cold atmospheric plasma. Journal of Bioscience and Bioengineering. 2023. 136. 2. 123-128
Noboru Furutani, Shingo Izawa. Adaptability of wine yeast to ethanol-induced protein denaturation. FEMS Yeast Research. 2022. 22. 2. foac059,

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MISC (87)：

吉田雅偲, 井沢真吾. Proteostasis in Yeast Cells Under Ethanol Stress and During Wine Making Process. 日本醸造協会誌. 2022. 117. 6
IZAWA Shingo. Application of cold atmospheric pressure plasma in the food industry ad agriculture. ILSI Japan. 2020
HOMOTO Sena, IZAWA Shingo. Formation of multiple small rings of yeast septin under long-term severe ethanol stress. Bioscience and Industry. 2019. 77. 3. 233-235
松山崇, 伊藤洋一郎, 北川孝雄, 山西守, 片平悟史, 井沢真吾, 入江賢児, 清木誠. DIT1ターミネーターと2つのRNA結合タンパク質による目的タンパク質の増産. 日本農芸化学会大会講演要旨集(Web). 2018. 2018
松山崇, 伊藤洋一郎, 北川孝雄, 山西守, 片平悟史, 井沢真吾, 入江賢児, 清木誠. DIT1ターミネーターと2つのRNA結合タンパク質による目的タンパク質の増産技術. 日本生物工学会大会講演要旨集. 2017. 69th

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Patents (5)：

Production methods of high value yeast
Production method of yeast cells containing high level thioredoxin
Yeast with high tolerance to freezing/thawing stress
Production of thioredoxin
Stress responsive promoter of yeast

Books (7)：

Applied RNA Bioscience (ed. S. Masuda & S. Izawa)
Springer Verlag Tokyo 2018
Stress Biology of Yeast and Fungi (ed. Takagi H & Kitagaki H.)
Springer Verlag Tokyo 2015
Frontiers in fermented foods
CMC press 2014
Life science and biotechnology of yeasts
Kagaku Dojin 2013
New technology and functions of fermented foods 2
CMC press 2011

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Lectures and oral presentations (26)：

Survival strategy of yeast cells under severe ethanol stress
(The 14th open seminar of Applied Biological Chemistry Research Center, Kagawa University 2019)
Survival strategy of yeast under severe ethanol stress
(22nd Yeast godo symposium 2018)
Survival strategy of yeast at the final stage of brewing process
(112nd meeting of fermentation technology 2018)
Study on yeast genes preferentialy translated under severe ethanol stress
(H29 annual meeting of sake yeast and kouji research 2017)
Yeast responses and adaptation to long-time severe ethanol stress
(20th annual meeting of eukaryotic microorganisms 2017)

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Education (2)：

1992 - 1995 Kyoto University Grad. School Agriculture Div. Food Technology
1988 - 1992 Kyoto University School of Agriculture Department of Food Technology

Professional career (2)：

Master of Agriculture (Kyoto University)
Doctor of Agriculture (Kyoto University)

Work history (6)：

2024/01 - 現在 Kyoto Institute of Technology Grad. School of Science and Technology, Div. Appl. Biol. Professor
2009/02 - 2023/12 Kyoto Institute of Technology Grad. School of Science and Technology, Div. Appl. Biol. associate professor
2007/04 - 2009/02 Kyoto University Grad. School Agriculture, Div. Appl. Biosciences assistant professor
2001/04 - 2007/03 Kyoto University Grad. School Agriculture, Div. Appl. Biosciences assistant professor
2000/04 - 2001/04 Harvard University Dana-Farber Cancer Institute Monbusyo Fellowship Researcher to Study Abroad

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Awards (5)：

2021/12 - Ohsumi Frontier Science Foundation Yeast Consortium Fellow
2017/04 - Nagase Science and Technology Foundation Nagase award for science promotion
2010/03 - Kyoto Trust Bank Hirameki award, 2nd Kyushin Chiki-no kizunadukuri awards Breeding of high brands of traditional fermented foods of Kyoto
2008/03 - The Japan Society for Bioscience, Biotechnology, and Agrochemistry encouragement award of JSBBA
1999/11 - International Symposium for Oxidative Stress, Redox Regulation and Signal Transduction Best poster award Effects of thioredoxin and glutaredoxin systems on the activity of Yap1, an AP-1 like transcription factor in Saccharomyces cerevisiae

Association Membership(s) (8)：

Yeast Workshop , Yeast Research Community , Yeast Genetics Society of Japan , 日本RNA学会 , 日本分子生物学会 , 日本生物工学会 , 日本生化学会 , 日本農芸化学会

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