Higashi Tsunehito

Higashi Tsunehito | Higashi Tsunehito

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://plaza.umin.ac.jp/cellular_pharm/?p=12

Research field (4)： Environmental effects of chemicals , Environmental effects of radiation , Pharmacology , Applied biofunctional and bioprocess engineering

Research keywords (3)：細胞毒性 , 不飽和カルボニル化合物 , 動物細胞工学

Research theme for competitive and other funds (6)：

2021 - 2024 不飽和カルボニル化合物によるPKCを介した新しいフェロトーシス誘導機序の解明
2018 - 2021 The role of PKC for unsaturated carbonyl compounds-induced cell injury and disease onset
2014 - 2017 Elucidation of molecular mechanism for development of atherosclerosis by cytotoxic factors in cigarette smoke
2008 - 2009 Basic research for improvement of productivity of bio-medicines based on cell quality control system
2007 - 2008 Studies on gating and permission mechanisms for maturation of secretory cargo proteins

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Papers (50)：

Tsunehito Higashi, Haruka Handa, Yosuke Mai, Katsumi Maenaka, Takashi Tadokoro. Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages. Journal of Pharmacological Sciences. 2023. 153. 1. 22-25
Higashi Tsunehito, Handa Haruka, Mai Yosuke, Maenaka Katsumi, Tadokoro Takashi. Cigarette smoke gas phase induces ferroptosis via PKCβ in J774 macrophages. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023. 97. 3-B-P-069
Tomaru U, Ito T, Ohmura Y, Higashikawa K, Miyajima S, Tomatsu R, Higashi T, Ishizu A, Kuge Y, Yoshioka M, et al. Decreased proteasomal function induces neuronal loss and memory impairment. Am J Pathol. 2021. 191. 1. 144-156
Sampilvanjil A, Karasawa T, Yamada N, Komada T, Higashi T, Baatarjav C, Watanabe S, Kamata R, Ohno N, Takahashi M. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2020. 318. 3. H508-H518
Myobatake Y, Kamisuki S, Tsukuda S, Higashi T, Chinen T, Takemoto K, Hachisuka M, Suzuki Y, Takei M, Tsurukawa Y, et al. Pyrenosine A induces monopolar spindle formation and suppress proliferation of cancer cells. Bioorg Med Chem. 2019. 27. 23. 115149-115149

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MISC (9)：

眞井洋輔, 氏家英之, 東恒仁, 岩田浩明, 清水宏. CLEIAで検出されない抗デスモグレイン3抗体は抗原との結合速度が遅い. 日本皮膚科学会雑誌. 2018. 128. 4. 607-607
真崎雄一, 小野寺康仁, 東恒仁, 堀之内孝広, 及川司, 佐邊壽孝. 好中球のケモタキシスにおいて,ARF1の活性化は,ARF1-RAC1の相互制御回路を開始する. 日本細胞生物学会大会(Web). 2017. 69th. ROMBUNNO.T8-11(P1-077) (WEB ONLY)-63
東恒仁, 眞井洋輔, 真崎雄一. 不飽和カルボニル化合物による細胞死誘導の分子機構の解明. 日本生化学会大会(Web). 2017. 90th
堀之内孝広, 寺田晃士, 東恒仁, 真崎雄一, 三輪聡一. Phos-tag biotinを用いた受容体作動性TRPC6チャネルのPKAリン酸化部位の同定. 電気泳動(Web). 2016. 60. Suppl
T. Higashi, Y. Mai, Y. Mazaki, T. Horinouchi, S. Miwa. Unsaturated carbonyl compounds in the gas phase of cigarette smoke induces cell death through intracellular Ca2+-dependent PKC activation. MOLECULAR BIOLOGY OF THE CELL. 2016. 27

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Lectures and oral presentations (31)：

In vitroアッセイによる環境毒性因子の呼吸器系への影響の解明
(Program & Abstracts. Annual and International Meeting of the Japanese Association for Animal Cell Technology 2022)
Cytotoxic mechanisms and physiological effects of unsaturated carbonyl compounds
(環境ホルモン学会研究発表会プログラム・要旨集 2021)
The roles of Annexin A in ERK activation upon endothelin-1 stimulation
(日本分子生物学会年会プログラム・要旨集(Web) 2021)
不飽和カルボニル化合物による細胞死に関与するPKCアイソフォームの同定
(日本分子生物学会年会プログラム・要旨集(Web) 2020)
システイン誘導体による煙中の不飽和カルボニル化合物の解毒メカニズムの解明
(日本生物工学会大会講演要旨集 2019)

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Education (3)：

2003 - 2006 大阪大学大学院工学研究科応用生物工学専攻博士後期課程
2001 - 2003 大阪大学大学院工学研究科応用生物工学専攻博士前期課程
1997 - 2001 Osaka University School of Engineering Department of Applied Science

Professional career (1)：

博士(工学) (大阪大学)

Work history (7)：

2012 - 現在 Hokkaido University Graduate School of Medicine
2011 - 2012 Tokyo University of Science
2009 - 2011 University of California San Diego Postdoctoral Fellow
2007 - 2009 Fukushima Medical University School of Medicine
2007 - 2007 Fukushima Medical University School of Medicine

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Association Membership(s) (5)：

The American Society for Cell Biology , THE JAPANESE PHARMACOLOGICAL SOCIETY , 日本生物工学会 , 日本分子生物学会 , 日本動物細胞工学会

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